Long-Term Survival After Cisplatin-Based Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma: A Pooled Data Analysis of Two Phase III Trials

Chua, Daniel T.T.; Ma, Jun; Sham, Jonathan S. T.; Qiang, Hai; Choy, D.; Hong, Ming; Lu, Tai Xiang; Min, Hua

doi:10.1200/jco.2005.12.081

Cited by 219 publications

(138 citation statements)

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“…In a report of pooled data of two prospective randomized trials [16], the use of induction CHT resulted in a 5.4% improvement in disease specific survival rate (p= 0.029) at 5 years, while no significant difference was found in the overall survival rates.…”

Section: Discussionmentioning

confidence: 99%

Induction chemotherapy with carboplatin and taxol followed by radiotherapy and concurrent weekly carboplatin + taxol in locally advanced nasopharyngeal carcinoma

Airoldi

Gabriele

et al. 2010

Cancer Chemother Pharmacol

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Methods: Thirty patients were treated with three cycles of carboplatin (AUC6) plus taxol (175mg/m 2 ) on day 1 every 3 weeks, followed by weekly carboplatin (AUC1) plus Taxol (60mg/m2) and concomitant radiotherapy (70Gy). Results:We observed the objective complete response rates of 33% (after chemotherapy) and 87%(after chemo-radiotherapy). Treatment tolerability and toxicity were controllable. Three and five years progression free survival were 80% and 75% respectively and 3 and 5 years overall survival were 85% and 80% (follow-up 49.5 months). Five years loco-regional control was 90.3% and five years distant metastases free survival was 85%.Conclusions: Neoadjuvant-chemotherapy with such protocol represents a feasible, efficient treatment for patients with A-NPC, ensuring excellent locoregional disease control and overall survival with low incidence of distant metastases.

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Section: Discussionmentioning

confidence: 99%

Induction chemotherapy with carboplatin and taxol followed by radiotherapy and concurrent weekly carboplatin + taxol in locally advanced nasopharyngeal carcinoma

Airoldi

Gabriele

et al. 2010

Cancer Chemother Pharmacol

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“…5 Â 10 5 6/6 6/6 1 Â 10 5 5/6 3/6 5 Â 10 4 3/6 0/6 1 Â 10 4 2/6 0/6 5 Â 10 3 2/6 0/6 1 Â 10 3 0/6 0/6 NOTE: Mice were injected with serial dilutions of S18 or S26 cells and were observed twice per week for 5 weeks.…”

Section: Smac Mimetics In Combination With Trail Can Induce Iap Degramentioning

confidence: 99%

“…However, some patients still suffered from failure of treatment including relapse and metastasis, which is thought to originate from cancer stem cells (CSC; refs. [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Smac Mimetics in Combination with TRAIL Selectively Target Cancer Stem Cells in Nasopharyngeal Carcinoma

Wu¹,

Wang²,

Zhao³

et al. 2013

Molecular Cancer Therapeutics

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Nasopharyngeal carcinoma is a common malignancy in Southern China. After radiotherapy and chemotherapy, a considerable proportion of patients with nasopharyngeal carcinoma suffered tumor relapse and metastasis. Cancer stem cells (CSC) have been shown with resistance against therapies and thus considered as the initiator of recurrence and metastasis in tumors, where the antiapoptotic property of CSCs play an important role. Smac/DIABLO is an inverse regulator for the inhibitors of apoptosis protein family (IAP), which have been involved in apoptosis. Here, the effects of Smac mimetics on the CSCs of nasopharyngeal carcinoma were studied both in vitro and in vivo, using two clones of nasopharyngeal carcinoma cell line CNE2 as models. We found that one of the clones, S18, had CSC-like properties and IAPs were overexpressed. The combination of Smac mimetics and TNF-related apoptosis-inducing ligand (TRAIL) can reduce the percentage of SP cells and inhibit the colonyand sphere-forming abilities of S18 cells, indicating their ability to attenuate the CSCs. Moreover, in a nasopharyngeal carcinoma xenograft model, the administration of Smac mimetics in combination with TRAIL also led to the elimination of nasopharyngeal carcinoma stem cells. Furthermore, the Smac mimetics in combination with TRAIL induced the degradation of cIAP1 and XIAP and thus induced apoptosis in vitro and in vivo. Taken together, our data show that Smac mimetics exerted an antitumor effect on nasopharyngeal carcinoma cancer stem cells, and this combination treatment should be considered as a promising strategy for the treatment of nasopharyngeal carcinoma. Mol Cancer Ther; 12(9); 1728-37. Ó2013 AACR.

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“…Despite recent advances in radiation techniques and chemotherapy, local failure and distant metastasis remain poor survival in patients with advanced NPC [2].…”

Section: Introductionmentioning

confidence: 99%

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

et al. 2013

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(T. Yoshizaki). Keywords:seven-in-absentia homologue 1 (Siah1) hypoxia-inducible factor 1 alpha (HIF1α) latent membrane protein 1 (LMP1) Epstein-Barr virus (EBV) nasopharyngeal carcinoma ABSTRACT Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1α-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis.

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Long-Term Survival After Cisplatin-Based Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma: A Pooled Data Analysis of Two Phase III Trials

Abstract: The addition of cisplatin-based induction chemotherapy to RT was associated with a modest but significant decrease in relapse and improvement in disease-specific survival in advanced-stage NPC. However, there was no improvement in overall survival.

Cited by 219 publications

References 21 publications

Induction chemotherapy with carboplatin and taxol followed by radiotherapy and concurrent weekly carboplatin + taxol in locally advanced nasopharyngeal carcinoma

Induction chemotherapy with carboplatin and taxol followed by radiotherapy and concurrent weekly carboplatin + taxol in locally advanced nasopharyngeal carcinoma

Smac Mimetics in Combination with TRAIL Selectively Target Cancer Stem Cells in Nasopharyngeal Carcinoma

Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: Novel prognostic factors of nasopharyngeal carcinoma

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