Long-Term Supplementation of Green Tea Extract Does Not Modify Adiposity or Bone Mineral Density in a Randomized Trial of Overweight and Obese Postmenopausal Women

Dostal, Allison M.; Arikawa, Andrea Y.; Espejo, L. A.; Kurzer, Mindy S.

doi:10.3945/jn.115.219238

Cited by 60 publications

(55 citation statements)

References 54 publications

(53 reference statements)

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“…Since the completion of this meta-analysis, additional RCTs investigating the effects of tea or cocoa products containing flavanols on lipid and anthropometric variables have been added to the existing literature [111,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183]. The heterogeneity of these trials remains high with population samples including mixed sexes and ages, obese, overweight, healthy, hyperlipidemic and/or diabetic subjects, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Others show no significant effects on these variables [175]. Noteworthy, some of these trials included stratification analyses by baseline conditions, medication, disease, age, sex, or even genotype and further point to specific responses in some subgroups [169,172,174,176,179]. Likewise, the intake of a cocoa product caused a greater increased of HDL in normocholesterolemic patients than in dyslipidemic patients [176], green tea capsules caused a significant reduction of total-cholesterol in women with a cholesterol baseline value above 5.17 mmol/L [169] or of LDL-cholesterol in patients not receiving anti-hyperlipidemic drugs [179].…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, the intake of a cocoa product caused a greater increased of HDL in normocholesterolemic patients than in dyslipidemic patients [176], green tea capsules caused a significant reduction of total-cholesterol in women with a cholesterol baseline value above 5.17 mmol/L [169] or of LDL-cholesterol in patients not receiving anti-hyperlipidemic drugs [179]. Of note, the interactions between two factors: baseline BMI and catechol- O -methyltransferase (COMT) genotype, was also recently investigated although the COMT genotype did not modify the effect of green tea extract on any of the variables investigated including BMI [172]. In our study, we were able to identify several factors that may contribute to explaining the heterogeneity on the BMI changes in response to the flavanol-containing products.…”

Section: Discussionmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy

et al. 2017

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Several randomized controlled trials (RCTs) and meta-analyses support the benefits of flavanols on cardiometabolic health, but the factors affecting variability in the responses to these compounds have not been properly assessed. The objectives of this meta-analysis were to systematically collect the RCTs-based-evidence of the effects of flavanol-containing tea, cocoa and apple products on selected biomarkers of cardiometabolic risk and to explore the influence of various factors on the variability in the responses to the consumption of these products. A total of 120 RCTs were selected. Despite a high heterogeneity, the intake of the flavanol-containing products was associated using a random model with changes (reported as standardized difference in means (SDM)) in body mass index (−0.15, p < 0.001), waist circumference (−0.29, p < 0.001), total-cholesterol (−0.21, p < 0.001), LDL-cholesterol (−0.23, p < 0.001), and triacylglycerides (−0.11, p = 0.027), and with an increase of HDL-cholesterol (0.15, p = 0.005). Through subgroup analyses, we showed the influence of baseline-BMI, sex, source/form of administration, medication and country of investigation on some of the outcome measures and suggest that flavanols may be more effective in specific subgroups such as those with a BMI ≥ 25.0 kg/m2, non-medicated individuals or by specifically using tea products. This meta-analysis provides the first robust evidence of the effects induced by the consumption of flavanol-containing tea, cocoa and apple products on weight and lipid biomarkers and shows the influence of various factors that can affect their bioefficacy in humans. Of note, some of these effects are quantitatively comparable to those produced by drugs, life-style changes or other natural products. Further, RCTs in well-characterized populations are required to fully comprehend the factors affecting inter-individual responses to flavanol and thereby improve flavanols efficacy in the prevention of cardiometabolic disorders.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy

et al. 2017

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“…[42] The above 2 studies, which were not adjusted, were inconsistent with our series. Besides, a prospective randomized controlled study also found no correlation between tea and BMD, [43] the main reason likely being the small sample size.…”

Section: Discussionmentioning

confidence: 99%

Updated association of tea consumption and bone mineral density

et al. 2017

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Background:Current studies evaluating the association of tea consumption and bone mineral density (BMD) have yielded inconsistent findings. Therefore, we conducted a meta-analysis to assess the relationship between tea consumption and BMD.Methods:The PubMed, Embase, and Cochrane Library databases were comprehensively searched, and a meta-analysis performed of all observational studies assessing the association of tea consumption and BMD. Forest plots were used to illustrate the results graphically. The Q-test and I2 statistic were employed to evaluate between-study heterogeneity. Potential publication bias was assessed by the funnel plot.Results:Four cohort, 1 case–control, and 8 cross-sectional studies including a total of 12,635 cases were included. Tea consumption was shown to prevent bone loss [odds ratio (OR): 0.66; 95% confidence interval (CI), 0.47–0.94; P = 0.02], yielding higher mineral densities in several bones, including the lumbar spine [standardized mean difference (SMD): 0.19; 95% CI, 0.08–0.31; P = 0.001], hip (SMD: 0.19; 95% CI, 0.05–0.34; P = 0.01), femoral neck [mean difference (MD): 0.01; 95% CI, 0.00–0.02; P = 0.04], Ward triangle (MD: 0.02; 95% CI, 0.01–0.04; P = 0.001), and greater trochanter (MD: 0.03; 95% CI, 0.02–0.04; P < 0.00001), than the non-tea consumption group.Conclusion:This meta-analysis provided a potential trend that tea consumption might be beneficial for BMD, especially in the lumbar spine, hip, femoral neck, Ward triangle, and greater trochanter, which might help prevent bone loss.

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“…The outcome measures included body mass index; total fat mass; percentage of body fat; BMD; and circulating leptin, ghrelin, adiponectin, and insulin 68. Green tea extract may be beneficial in reducing tissue and gynoid percentage fat in individuals with higher body mass index, but there were no changes in any circulating parameters 68.…”

Section: Human Clinical Trialsmentioning

confidence: 99%

Tea Flavonoids for Bone Health: From Animals to Humans

Shen

Chyu

2016

Journal of Investigative Medicine

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Osteoporosis is a skeletal disease characterized by a deterioration of bone mass and bone quality that predisposes an individual to a higher risk of fragility fractures. Emerging evidence has shown that the risk for low bone mass and osteoporosis-related fractures can be reduced by nutritional approaches aiming to improve bone microstructure, bone mineral density, and strength. Tea and its flavonoids, especially those of black tea and green tea, have been suggested to protect against bone loss and to reduce risk of fracture, due to tea's antioxidant and anti-inflammatory properties. Based on the results of animal studies, moderate intake of tea has shown to benefit bone health as shown by mitigation of bone loss and microstructural deterioration as well as improvement of bone strength and quality. Epidemiological studies have reported positive, insignificant, and negative impacts on bone mineral density at multiple skeletal sites and risk of fracture in humans with habitual tea consumption. There are limited human clinical trials that objectively and quantitatively assessed tea consumption and bone efficacy using validated outcome measures in a population at high risk for osteoporosis, along with safety monitoring approach. This review summarizes the current state of knowledge of laboratory animal research, epidemiological observational studies, and clinical trials assessing the skeletal effects of tea and its active flavonoids, along with discussion of relevant future directions in translational research.

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Long-Term Supplementation of Green Tea Extract Does Not Modify Adiposity or Bone Mineral Density in a Randomized Trial of Overweight and Obese Postmenopausal Women

Cited by 60 publications

References 54 publications

A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy

A Systematic Review and Meta-Analysis of the Effects of Flavanol-Containing Tea, Cocoa and Apple Products on Body Composition and Blood Lipids: Exploring the Factors Responsible for Variability in Their Efficacy

Updated association of tea consumption and bone mineral density

Tea Flavonoids for Bone Health: From Animals to Humans

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