Long term substitution and specific immune responses after transfer of bovine peripheral blood lymphocytes into severe combined immunodeficient mice

A Chemically Induced Vaccine Strategy for Prostate Cancer

“…Immunostaining with an anti-CD4 antibody did not reveal significant differences between tumors obtained from the different experimental groups (Supplementary Figure S7i), suggesting that the population of lymphocytes infiltrating the tumors is largely NK cells and CD8 + cytotoxic T cells. CD8 + cytotoxic T lymphocyte (CTL)-dependent immunity is known to contribute to the PBL-dependent suppression of tumor xenografts in hu-PBL-NOD/SCID mouse models. − The CTL immune response might also be expected to be high in LNCaP tumor cells treated with ligand 1 that are dying by ADCC, since this mechanism of cytotoxicity can enhance tumor cell immunogenicity . Previous reports suggest that a considerable fraction of the PBL injected into SCID mice might be specific to the host antigens.…”