Long-term study (2005–2010) on the vaccination with BoHV-1 glycoprotein E-deleted marker vaccine in selected two dairy herds in Turkey

Alkan, Feray; Bilge-Dagalp, S.; Karapınar, Zeynep; Timurkan, Mehmet Ozkan; Coşkun, Nüvit; Burgu, İbrahim

doi:10.1007/s11250-017-1440-3

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…The gE-deleted vaccine can be distinguished from wild virus infection or vaccine immunity by the antibodies produced after vaccination. The BHV-1 gE-deleted vaccine is the most widely used labeled vaccine, using serum collected at approximately 6-month intervals for 5 consecutive years, serologically screened for gE-specific antibodies by ELISA to eradicate BHV-1 infection ( Tignon et al, 2017 ; Alkan et al, 2018 ; Petrini et al, 2019 ). The gE CTD protein can be used as an indicator antibody and coating antigen for the gE CTD-specific blocking ELISA test to distinguish between BHV-1 wild strains or gE CTD deletion strain-infected calves ( Chowdhury, 2016 ).…”

Section: Deleted Marker Vaccines Designed With Gementioning

confidence: 99%

Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology

et al. 2022

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The viral envelope glycoprotein E (gE) is required for cell-to-cell transmission, anterograde and retrograde neurotransmission, and immune evasion of alphaherpesviruses. gE can also interact with other proteins of the virus and perform various functions in the virus life cycle. In addition, the gE gene is often the target gene for the construction of gene-deleted attenuated marker vaccines. In recent years, new progress has been made in the research and vaccine application of gE with other proteins of the virus. This article reviews the structure of gE, the relationship between gE and other proteins of the virus, and the application of gE in vaccinology, which provides useful information for further research on gE.

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Section: Deleted Marker Vaccines Designed With Gementioning

confidence: 99%

Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology

et al. 2022

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“…In Turkey, numerous studies have investigated BoHV-1 and BVDV as aetiological agents of fertility problems, such as abortion, and have conducted serological screening of antibodies against these agents (Alkan & Burgu 1993;Alkan et al 2005Alkan et al , 2009Alkan et al , 2018Bilge-Dagalp et al 2008;Oğuzoğlu et al 2012;Tan et al 2006). There have also been virological and serological studies on BoHV-4 infection.…”

Section: Introductionmentioning

confidence: 99%

An assessment of bovine herpes virus 4 as a causative agent in abortions and neonatal death

Dağalp

Babaoğlu

Doğan

et al. 2020

Onderstepoort Journal of Veterinary Research

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Numerous viruses, including bovine viral diarrhoea virus (BVDV), bovine herpes virus 1 (BoHV-1) and bovine herpes virus 4 (BoHV-4), and other pathogens are the most common causes of reproductive disorders and are responsible for huge economic losses in livestock production. This study investigates the aetiological role of BoHV-4 in fertility problems such as abortions, stillbirth and birth with unviable calves. Retrospective samples from 38 animals, including 17 aborting cows, 17 aborted foetuses, three stillborn calves and one unviable newborn calf were analysed. The BoHV-4 genome was detected in 25 (65.7%) animals by polymerase chain reaction. In 14 of these infected animals, we detected co-infection with BVDV, while the co-presence of BoHV-1 was also detected in one animal. In addition to the high prevalence of BoHV-4 genome in materials related to fertility problems, isolation of BoHV-4 from the brain of one stillborn calf indicated a causal link between BoHV-4 and fertility problems, such as abortion, stillbirths or birth with unviable calves.

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Impact of bovine herpesvirus-1 infection on fertility in dairy cattle

Henderson,

Caldow

2023

Livestock

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Bovine herpesvirus-1 (BoHV-1) is endemic in the UK dairy herd and can have an important negative impact on fertility. As well as being the cause of infectious pustular vulvovaginitis and infectious balanoposthitis, BoHV-1 can reduce conception rate following introduction of the virus in contaminated semen at the time of artificial insemination. Its ability to cause abortions, particularly in the last trimester, is well-documented and the incidence of abortions can be high following the introduction of infection to naïve herds. The impact of BoHV-1 on herd fertility will depend on the degree of herd immunity, route of infection and strain of BoHV-1. Vaccination has been shown to reduce spread of BoHV-1 within and between herds, and to significantly reduce the risk of abortion. In light of the cost of a single abortion, and the impact of BoHV-1 on milk yield, routine vaccination against BoHV-1 offers a cost-effective control strategy suitable for most UK dairy herds.

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Long-term study (2005–2010) on the vaccination with BoHV-1 glycoprotein E-deleted marker vaccine in selected two dairy herds in Turkey

Cited by 5 publications

References 24 publications

Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology

Alphaherpesvirus glycoprotein E: A review of its interactions with other proteins of the virus and its application in vaccinology

An assessment of bovine herpes virus 4 as a causative agent in abortions and neonatal death

Impact of bovine herpesvirus-1 infection on fertility in dairy cattle

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