Long-term stability of conservative orthodontic treatment in a patient with temporomandibular joint disorder

Mitsui, Silvia Naomi; Yasue, Akihiro; Kuroda, Shingo; Tanaka, Eiji

doi:10.4103/2278-0203.186168

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Currently, TMD therapy involves jaw exercise, ultrasound, and acupuncture (Armijo-Olivo et al, 2016). Treatment mainly focuses on relieving pain and improving TMJ biofunctions; however, these effects tend to be reversible and conservative (Mitsui et al, 2016). Low-intensity pulsed ultrasound (LIPUS), which uses a low frequency (1-3 MHz) and an intensity less than 100 mW/cm 2 (Nagao et al, 2017), exerts pleiotropic biological effects via its mechanical actions and weak thermal effects (Vaughan et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Low-Intensity Pulsed Ultrasound Alleviates Hypoxia-Induced Chondrocyte Damage in Temporomandibular Disorders by Modulating the Hypoxia-Inducible Factor Pathway

et al. 2020

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Temporomandibular disorders are a common cause of chronic pain in the orofacial region and have a complex and multi-factorial pathophysiology. Mechanical loading or inflammatory conditions have been shown to decrease oxygen tension within the joint cartilage and activate the hypoxia-inducible factor (HIF) pathway, which in turn aggravates the pathological processes underlying temporomandibular joint (TMJ) disorders. We previously showed that low-intensity pulsed ultrasound (LIPUS) treatment effectively repairs TMJ injury induced by chronic sleep deprivation (CSD). Here, we explored the effects of LIPUS treatment on hypoxia-induced chondrocyte injury. We found that it effectively restored the proliferation capacity of mandibular chondrocytes under hypoxic conditions and lowered their rate of apoptosis. Chondrogenic capacity, as assessed by type II collagen levels, and mucin-positive areas were also significantly increased after LIPUS treatment. Levels of matrix metalloprotein-3 and interleukin-6 decreased in mandibular chondrocytes following this treatment, whereas the expression of tissue inhibitor of metalloproteinase-1 increased. We also found that HIF-1a expression was upregulated in mandibular chondrocytes under hypoxic conditions and was further enhanced by LIPUS treatment. Similarly, HIF-2a levels increased in mandibular chondrocytes under hypoxic conditions but decreased following LIPUS treatment. Subsequently, we established a CSD-induced TMJ injury model and found that LIPUS increased mucin-positive areas as well as HIF-1a expression and decreased HIF-2 level in the chondrocyte layer. Together, our results indicate that the protective effect of LIPUS on chondrocyte is partly associated with the HIF pathway.

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Section: Introductionmentioning

confidence: 99%

Low-Intensity Pulsed Ultrasound Alleviates Hypoxia-Induced Chondrocyte Damage in Temporomandibular Disorders by Modulating the Hypoxia-Inducible Factor Pathway

et al. 2020

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“…Schüller’s view also revealed that there was no change of condyle shape and jaw movement before and after orthodontic treatment. However, a recent study showed that splint therapy can be continued during the first several months with orthodontic treatment by adjustment of the splint according to the tooth movement [29]. So, simultaneous recovery in the TMJ with the orthodontic treatment might be achieved without delay of the treatment in this case.…”

Section: Discussionmentioning

confidence: 99%

Correction of skeletal class II severe open bite with temporomandibular joint disorder treated by miniscrew anchorage and molar extraction: a case report

et al. 2019

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Background Little information is available on the treatment of open bite with temporomandibular joint disorder by intrusion of molars using miniscrews. Case presentation This case report describes a 42-year-old Japanese woman with a skeletal class II severe anterior open bite and temporomandibular joint disorder. The pretreatment magnetic resonance imaging of both temporomandibular joints revealed osteoarthritis and anterior disc displacement without reduction in both temporomandibular joints. A stabilization splint was used before orthodontic treatment and bilateral upper and lower premolars were extracted. Miniscrews were inserted into the palatal region to intrude the maxillary molars and avoid loss of anchorage. The maxillary left first molar was also extracted to improve the molar relationship and the dental midline. Normal overjet and overbite with Angle class I molar relationship were achieved, and the upper and lower midlines coincided. Our patient’s teeth continued to be stable and her temporomandibular joint was asymptomatic after a retention period of 2 years. Conclusions Intrusion of molars by miniscrews is available for skeletal class II severe open bite.

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“…Occlusion splints, however, are effective in releasing TMJ involuntary overloading and to reduce the muscle hyperactivity. Moreover, a subsequent occlusion reconstruction achieved by postoperative splints can help to maintain an optimal environment within the TMJ, thus leading to bone osteogenesis and reducing relapse rate 34 . In our study, almost 610 patients have the habit of nocturnal bruxism and 345 patients took functional splint treatment after arthroscope surgery with 48.51% detected of bone remodeling.…”

Section: Discussionmentioning

confidence: 99%

A Prognostic Nomogram for Postoperative Bone Remodeling in Patients with ADDWoR

Liu

Shen

Wang

et al. 2018

Sci Rep

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This study aimed to establish an effective prognostic nomogram for predicting the probability of postoperative bone remodeling of patients with anterior disc displacement without reduction (ADDWoR). The nomogram was based on a retrospective study on patients underwent surgical approaches for ADDWoR at Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University from January, 2007 to January, 2017. A multivariate logistic regression analysis was used to develop variables suitable for probability estimation model. The predictive accuracy and discriminative ability were determined by ROC (AUC-index) and calibration curve. Results were validated using bootstrap resampling with all statistical tests two-sided. 1110 patients were included in the analysis. The probability of postoperative bone remodeling in ADDWoR was 0.51. Six independent prognostic factors including age of onset, nocturnal bruxism, disc morphology, BMD, Wilkes’ classification, and postoperative splint therapy were integrated to construct the nomogram. The probability estimation model showed good discrimination in both internal and external validation with AUC-index of 0.84. The calibration curves for probability of postoperative bone remodeling showed optimal agreement with actual observation. In conclusion, a nomogram was established to provide individual prediction of postoperative bone remodeling for patients with ADDWoR treated by arthroscopy surgery.

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Long-term stability of conservative orthodontic treatment in a patient with temporomandibular joint disorder

Cited by 5 publications

References 16 publications

Low-Intensity Pulsed Ultrasound Alleviates Hypoxia-Induced Chondrocyte Damage in Temporomandibular Disorders by Modulating the Hypoxia-Inducible Factor Pathway

Low-Intensity Pulsed Ultrasound Alleviates Hypoxia-Induced Chondrocyte Damage in Temporomandibular Disorders by Modulating the Hypoxia-Inducible Factor Pathway

Correction of skeletal class II severe open bite with temporomandibular joint disorder treated by miniscrew anchorage and molar extraction: a case report

A Prognostic Nomogram for Postoperative Bone Remodeling in Patients with ADDWoR

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