Long-term stability of bone tissues induced by an osteoinductive biomaterial, recombinant human bone morphogenetic protein-2 and a biodegradable carrier

Kokubo, Satoshi; Mochizuki, Manabu; Fukushima, Shinji; Ito, Teruo; Nozaki, Kazutoshi; Iwai, Takaya; Takahashi, Koichiro; Yokota, Shoji; Miyata, Keiji; Sasaki, Nobuo

doi:10.1016/j.biomaterials.2003.08.030

Cited by 48 publications

(26 citation statements)

References 29 publications

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“…Numerous bone substitutes combining bone morphogenetic proteins (BMPs) are currently tested in order to reduce the need for bone graft transplantations. Recombinant human BMP-2 (rhBMP-2) [1][2][3][4][5][6][7][8][9][10] and rhBMP-7 [11][12][13][14][15][16][17] have proven successful in forming large volumes of new bone without autograft transplantation in critical-sized long bone defects in preclinical studies. Furthermore, these proteins are already in clinical use [18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis

et al. 2015

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Section: Introductionmentioning

confidence: 99%

BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis

et al. 2015

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“…These osteoconductive scaffolds are often combined with growth factors (osteoinductive) (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and/or with cells (osteogenic) (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32) to induce active stimulation of bone regeneration. The objective of most of these investigations is to enable bone defect healing, which remains an unsolved clinical problem.…”

mentioning

confidence: 99%

Porous scaffold architecture guides tissue formation

Cipitria

Lange

Schell

et al. 2012

Journal of Bone and Mineral Research

100

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Critical-sized bone defect regeneration is a remaining clinical concern. Numerous scaffold-based strategies are currently being investigated to enable in vivo bone defect healing. However, a deeper understanding of how a scaffold influences the tissue formation process and how this compares to endogenous bone formation or to regular fracture healing is missing. It is hypothesized that the porous scaffold architecture can serve as a guiding substrate to enable the formation of a structured fibrous network as a prerequirement for later bone formation. An ovine, tibial, 30-mm critical-sized defect is used as a model system to better understand the effect of the scaffold architecture on cell organization, fibrous tissue, and mineralized tissue formation mechanisms in vivo. Tissue regeneration patterns within two geometrically distinct macroscopic regions of a specific scaffold design, the scaffold wall and the endosteal cavity, are compared with tissue formation in an empty defect (negative control) and with cortical bone (positive control). Histology, backscattered electron imaging, scanning small-angle X-ray scattering, and nanoindentation are used to assess the morphology of fibrous and mineralized tissue, to measure the average mineral particle thickness and the degree of alignment, and to map the local elastic indentation modulus. The scaffold proves to function as a guiding substrate to the tissue formation process. It enables the arrangement of a structured fibrous tissue across the entire defect, which acts as a secondary supporting network for cells. Mineralization can then initiate along the fibrous network, resulting in bone ingrowth into a critical-sized defect, although not in complete bridging of the defect. The fibrous network morphology, which in turn is guided by the scaffold architecture, influences the microstructure of the newly formed bone. These results allow a deeper understanding of the mode of mineral tissue formation and the way this is influenced by the scaffold architecture. ß

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“…The primary drug release mechanism from reservoir systems is diffusion-controlled release, characterized as an initial ''burst release'' phase followed by a phase of slower drug release from the carrier. 79,[127][128][129][130]165 This is typical of hydrophilic matrices, without special modifications, that degrade in bulk when water enters the matrix and degradation occurs throughout the structure. 105,106,108 In contrast, hydrophobic matrices commonly degrade by surface erosion, exhibiting zero-order release kinetics without a burst release phase.…”

Section: A Reservoir Systemsmentioning

confidence: 98%

“…[15][16][17][124][125][126] While calcium orthophosphate granules can be added to natural polymers to improve compression resistance, 124 synthetic polymers have been combined with other natural polymers demonstrating biocompatibility in order to improve their biological properties. 29,78,127 Natural and synthetic polymers have also been added to ceramics to optimize handling characteristics, provide injectability, and/or add porosity. 80,81,[128][129][130][131][132][133] As discussed previously, the macroporous hydrogel scaffolds containing microspheres loaded with growth factors were synthesized from both dextran-and gelatin-based biomaterials, which combined natural polymers to improve drug-controlling and structural properties.…”

Section: Biomaterials Compositesmentioning

confidence: 99%

Localized delivery of growth factors for periodontal tissue regeneration: Role, strategies, and perspectives

Chen

Shelton

Jin

et al. 2009

Medicinal Research Reviews

131

111

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Difficulties associated with achieving predictable periodontal regeneration, means that novel techniques need to be developed in order to regenerate the extensive soft and hard tissue destruction that results from periodontitis. Localized delivery of growth factors to the periodontium is an emerging and versatile therapeutic approach, with the potential to become a powerful tool in future regenerative periodontal therapy. Optimized delivery regimes and well-defined release kinetics appear to be logical prerequisites for safe and efficacious clinical application of growth factors and to avoid unwanted side effects and toxicity. While adequate concentrations of growth factor(s) need to be appropriately localized, delivery vehicles are also expected to possess properties such as protein protection, precision in controlled release, biocompatibility and biodegradability, self-regulated therapeutic activity, potential for multiple delivery, and good cell/tissue penetration. Here, current knowledge, recent advances, and future possibilities of growth factor delivery strategies are outlined for periodontal regeneration. First, the role of those growth factors that have been implicated in the periodontal healing/regeneration process, general requirements for their delivery, and the different material types available are described. A detailed discussion follows of current strategies for the selection of devices for localized growth factor delivery, with particular emphasis placed upon their advantages and disadvantages and future prospects for ongoing studies in reconstructing the tooth supporting apparatus.

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Long-term stability of bone tissues induced by an osteoinductive biomaterial, recombinant human bone morphogenetic protein-2 and a biodegradable carrier

Cited by 48 publications

References 29 publications

BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis

BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis

Porous scaffold architecture guides tissue formation

Localized delivery of growth factors for periodontal tissue regeneration: Role, strategies, and perspectives

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