Long-Term Stability of a Portable Carbon Monoxide Single-Breath Diffusing Capacity Instrument

Gochicoa‐Rangel, Laura; Pérez‐Padilla, Rogelio; Vázquez-García, Juan Carlos; Silva-Cerón, Mónica; Cid-Juárez, Silvia; Martínez-Briseño, David; Enright, Paul; Jensen, Robert L.; Torre-Bouscoulet, Luis

doi:10.4187/respcare.04983

Cited by 9 publications

(3 citation statements)

References 18 publications

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“…1 ). The conventional analysis was available in the EasyOne Pro device (software version V3.7.2.2), which has been shown to yield reliable values in previous studies [ 12 – 15 ]. The total-breath analysis was performed via a custom algorithm after export of the raw data, using the entire tracer gas (helium) concentration during inspiration and expiration (see Fig.…”

Section: Methodsmentioning

confidence: 99%

The total-breath method yields higher values of DLCO and TLC than the conventional method

Jörres,

Buess,

Piecyk

et al. 2024

BMC Pulm Med

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Background The 2017 ATS/ERS technical standard for measuring the single-breath diffusing capacity (DLCO) proposed the “rapid-gas-analyzer” (RGA) or, equivalently, “total-breath” (TB) method for the determination of total lung capacity (TLC). In this study, we compared DLCO and TLC values estimated using the TB and conventional method, and how estimated TLC using these two methods compared to that determined by body plethysmography. Method A total of 95 people with COPD (GOLD grades 1–4) and 23 healthy subjects were studied using the EasyOne Pro (ndd Medical Technologies, Switzerland) and Master Screen Body (Vyaire Medical, Höchberg, Germany). Results On average the TB method resulted in higher values of DLCO (mean ± SD Δ = 0.469 ± 0.267; 95%CI: 0.420; 0.517 mmol*min-1*kPa-1) and TLC (Δ = 0.495 ± 0.371; 95%CI: 0.427; 0.562 L) compared with the conventional method. In healthy subjects the ratio between TB and conventional DLCO was close to one. TLC estimated using both methods was lower than that determined by plethysmography. The difference was smaller for the TB method (Δ = 1.064 ± 0.740; 95%CI: 0.929; 1.199 L) compared with the conventional method (Δ = 1.558 ± 0.940; 95%CI: 1.387; 1.739 L). TLC from body plethysmography could be estimated as a function of TB TLC and FEV1 Z-Score with an accuracy (normalized root mean square difference) of 9.1%. Conclusion The total-breath method yielded higher values of DLCO and TLC than the conventional analysis, especially in subjects with COPD. TLC from the total-breath method can also be used to estimate plethysmographic TLC with better accuracy than the conventional method. The study is registered under clinicaltrial.gov NCT04531293.

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Section: Methodsmentioning

confidence: 99%

The total-breath method yields higher values of DLCO and TLC than the conventional method

Jörres,

Buess,

Piecyk

et al. 2024

BMC Pulm Med

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“…volumes, and cancer screening. Thoracic CT-scan examination in COPD patients is considered for patients with persistent exacerbation, a predicted FEV1 value <45% with hyperinflation, and who meet lung cancer screening criteria 19. …”

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confidence: 99%

Update on the Global Initiative for Chronic Obstructive Lung Disease (GOLD 2023)

Adrianison,

Simbolon,

Simatupang

2024

J Respirol Indones

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The overall increase in morbidity and mortality associated with chronic obstructive pulmonary disease (COPD) is inextricably linked to the concept of Global Initiative for Chronic Obstructive Lung Disease (GOLD) updates. An element of every GOLD update is directed toward policymakers, healthcare professionals, and people in general in order to evaluate the immediate and prolonged consequences of COPD. At this time, international interest is focused on the acceleration of the GOLD 2022 update to GOLD 2023 in an effort to enhance clinical management approaches for COPD, including individualized and comprehensive COPD treatment. The GOLD 2023 update will encompass the following aspects: definition and taxonomy, screening and case identification, diagnosis pathway, pharmacological and non-pharmacological approaches to managing stable COPD, and exacerbation management, as discussed in this review. GOLD 2023 explains that the diagnosis of emphysema has been classified as a pathologic diagnosis, in comparison with GOLD 2022. In the meantime, the clinical and epidemiological diagnosis of COPD is chronic bronchitis. The risk factor for tobacco smoke, which was once thought to be the primary cause of COPD, is described in GOLD 2023, together with the most recent taxonomy that has been developed to identify additional contributing components. The word "GET", which refers to the interaction of three risk factors-gene (G), environment (E), and lifetime (T)-that can cause lung damage and accelerate the aging or development of the lungs, is also linked to the most recent taxonomy of COPD. The switch from the "ABCD" approach to the "ABE" method for diagnosis and management of stable COPD is another significant modification included in the GOLD 2023 update. The number of COPD cases worldwide is expected to rise in the upcoming years as an outcome of long-term exposure to risk factors. Consequently, with the goal of increasing patient survival rates, GOLD 2023 highlights the significance of screening and early case discovery through the provision of non-pharmacological care.

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“…3 En cuanto a los analizadores de gases, éstos son cada vez más rápidos y requieren unos cuantos mililitros de volumen de muestra. 4 Contamos ahora con difusores portátiles que, a un costo relativamente bajo, permiten realizar la prueba de difusión pulmonar de monóxido de carbono con técnica de una sola respiración (DL,CO sb ). 5 Esta prueba, recordemos, es la mejor disponible para evaluar el intercambio de gases.…”

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La utilidad del volumen alveolar (V<sub>A</sub>) obtenido de la prueba de DL,CO<sub>sb </sub>

Gochicoa‐Rangel

Torre-Bouscoulet²

2019

NCT Neumología Y Cirugía De Tórax

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Long-Term Stability of a Portable Carbon Monoxide Single-Breath Diffusing Capacity Instrument

Abstract: Measurements of D were stable over the 3-y period without any need for manual recalibration of the instrument. The biological control was as good as the D simulator to evaluate this kind of device in a long-term laboratory quality control program.

Cited by 9 publications

References 18 publications

The total-breath method yields higher values of DLCO and TLC than the conventional method

The total-breath method yields higher values of DLCO and TLC than the conventional method

Update on the Global Initiative for Chronic Obstructive Lung Disease (GOLD 2023)

La utilidad del volumen alveolar (V<sub>A</sub>) obtenido de la prueba de DL,CO<sub>sb </sub>

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