Long-term somatic and mental development of children after periconceptional multivitamin supplementation

M, Dobó; Czeizel, Andr̀ew E.

doi:10.1007/s004310050922

Cited by 36 publications

(40 citation statements)

References 11 publications

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“…The prevalence of iron deficiency, based on the sTfR/ferritin ratio, did not differ between cases and controls. A beneficial effect of micronutrient supplementation, including Zn on recovery from acute otitis media (Dobo and Czeizel, 1998;Linday et al, 2002) and CSOM (Brooks et al, 2005) has been reported, although in these reports, the prevalence of micronutrient deficiency in study subjects was unclear. In the largest study from Bangladesh, a year's Zn supplementation (70 mg weekly) was associated, in children o2 years of age, with significant reduction in chronic suppurative ear disease (Brooks et al, 2005).…”

Section: Discussionmentioning

confidence: 84%

A case–control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children

et al. 2011

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Results: Cases had lower mean Z-scores for weight-for-age, weight-for-height, body mass index and mid-upper arm circumference (MUAC) (all Po0.05), and lower mean concentrations of serum Zn (P ¼ 0.032), Se (Po0.001) and calcium adjusted for albumin (P ¼ 0.026). Age-adjusted Hb and iron biomarkers did not differ between cases and controls. There was high prevalence of low serum Zn concentration (X90%) and vitamin D deficiency in both cases (80%) and controls (96%). Duration of ear discharge was negatively correlated with total 25(OH)D (P ¼ 0.028), calcium adjusted for albumin (Po0.001), PO 4 (P ¼ 0.002), transferrin receptor/ log ferritin ratio (Po0.001) and Cu (Po0.001), and positively correlated with child age and MUAC (both Po0.001). Conclusions: Children with CSOM were more undernourished than controls with lower mean serum Zn, Se and calcium concentrations. Vitamin D-deficient and iron-replete children had longer duration of infection, although this association was lost with age adjustment. Trials evaluating specific micronutrients are required in order to investigate specific nutrient-infection interactions in CSOM.

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Section: Discussionmentioning

confidence: 84%

A case–control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children

et al. 2011

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“…9,13,17 Only 2 studies included children at ages 2 and 6 years, and they did not find a beneficial effect of FA supplements on neuropsychological development. 18,19 It is also significant that the dosages of FA supplements used by pregnant women were very different among studies. Thus, current evidence makes it difficult to reach conclusions on whether the use of FA supplements may benefit child neurodevelopment.…”

mentioning

confidence: 98%

Folic Acid Supplements During Pregnancy and Child Psychomotor Development After the First Year of Life

et al. 2014

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“…There were no differences in the rate and distribution of disorders including allergies or any other adverse effect [54]. Therefore, the previously found association of atopic dermatitis, asthma, or wheezy bronchitis with maternal multivitamin supplementation during gestation was not confirmed [54].…”

Section: Folate and Postnatal Healthmentioning

confidence: 86%

“…There was no difference in the occurrence of serious or chronic diseases except for atopic dermatitis, asthma, and wheezy bronchitis which were more frequent in the infants of multivitamin-supplemented mothers [53]. In a long-term follow-up study on 6-year-old children of the same Hungarian trial, 147 children born to mothers with FA-containing multivitamin supplementation and 142 children who had mothers with trace element supplementation only were re-examined [54]. There were no differences in the rate and distribution of disorders including allergies or any other adverse effect [54].…”

Section: Folate and Postnatal Healthmentioning

confidence: 99%

“…In a long-term follow-up study on 6-year-old children of the same Hungarian trial, 147 children born to mothers with FA-containing multivitamin supplementation and 142 children who had mothers with trace element supplementation only were re-examined [54]. There were no differences in the rate and distribution of disorders including allergies or any other adverse effect [54]. Therefore, the previously found association of atopic dermatitis, asthma, or wheezy bronchitis with maternal multivitamin supplementation during gestation was not confirmed [54].…”

Section: Folate and Postnatal Healthmentioning

confidence: 99%

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Folate status and health: challenges and opportunities

Obeid¹,

Oexle

Rißmann

et al. 2016

Journal of Perinatal Medicine

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Abstract:Each year approximately 2400 pregnancies develop folic acid-preventable spina bifida and anencephaly in Europe. Currently, 70% of all affected pregnancies are terminated after prenatal diagnosis. The prevalence of neural tube defects (NTDs) has been significantly lowered in more than 70 countries worldwide by applying fortification with folic acid. Periconceptional supplementation of folic acid also reduces the risk of congenital heart diseases, preterm birth, low birth weight, and health problems associated with child mortality and morbidity. All European governments failed to issue folic acid fortification of centrally processed and widely eaten foods in order to prevent NTDs and other unwanted birth outcomes. The estimated average dietary intake of folate in Germany is 200 μg dietary folate equivalents (DFE)/day. More than half of German women of reproductive age do not consume sufficient dietary folate to achieve optimal serum or red blood cell folate concentrations ( > 18 or 1000 nmol/L, respectively) necessary to prevent spina bifida and anencephaly. To date, targeted supplementation is recommended in Europe, but this approach failed to reduce the rate of NTDs during the last 10 years. Public health centers for prenatal care and fortification with folic acid in Europe are urgently needed. Only such an action will sufficiently improve folate status, prevent at least 50% of the NTD cases, reduce child mortality and morbidity, and alleviate other health problems associated with low folate such as anemia.

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Long-term somatic and mental development of children after periconceptional multivitamin supplementation

Abstract: There were no differences in the rate and distribution of disorders including allergies (except otitis media), ophthalmological and audiological anomalies, anthropometric and mental development between children who belonged to the multivitamin or to the trace element group.

Cited by 36 publications

References 11 publications

A case–control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children

A case–control study of nutritional factors associated with chronic suppurative otitis media in Yemeni children

Folic Acid Supplements During Pregnancy and Child Psychomotor Development After the First Year of Life

Folate status and health: challenges and opportunities

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