Long-Term Social Outcomes of Hyperfractionated Radiation on Childhood ALL Survivors

Tang, Andrea; Alyman, Cheryl; Anderson, Loretta; Hodson, D. Ian; Marjerrison, Stacey

doi:10.1002/pbc.26027

Cited by 3 publications

(2 citation statements)

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“…Fourth, separate analysis of certain patient populations is essential to reduce selection bias. Many prior studies that found difficulties among patients included brain tumor survivors or those with acute lymphoblastic leukemia who received cranial radiation at a young age . Our study excluded these patient populations, which removes this as a confounding factor and is supported by a lack of difference in estimated IQ between our groups.…”

Section: Discussionmentioning

confidence: 86%

“…Additionally, some of the earlier studies that suggested difficulties evaluated patients treated in the 1970s and 1980s prior to widespread use of supportive care measures (ie, central lines, anti‐emetics, child life specialists, and conscious sedation for procedures) that have reduced patient's fear and improved quality of life . Lastly, the use of cranial radiation has decreased given the known neurocognitive effects, especially in the prophylactic setting for leukemia …”

Section: Introductionmentioning

confidence: 99%

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Internalizing symptoms in AYA survivors of childhood cancer and matched comparisons

et al. 2019

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Objective: As the number of pediatric cancer survivors increases, so does our need to understand behavioral late effects. Prior studies show mixed results, with some noting increased emotional distress and psychiatric diagnoses in cancer survivors and others suggesting resilience. The purpose of our study was to evaluate internalizing symptoms such as anxiety and depression in young adult survivors of childhood cancer compared with matched classroom matched peers. Method:We completed a multisource, cross-sectional examination of internalizing symptoms using a semistructured psychiatric interview with 18-year-olds with a history of pediatric cancer compared with age, race, and gender matched classroom peers who had been identified during the survivor's first year of treatment and their primary caregivers.Results: Fifty-seven young adult survivors of childhood cancer and 60 comparison peers participated. There were no significant differences between survivors and their peers on the basis of self-or parent-reported depressive or anxiety symptoms or number of psychiatric diagnoses. Conclusions:Young adult survivors of childhood cancer and their parents did not report increased rates of anxiety or depression compared with their former classroom peers. Despite experiencing a major life challenge, this group of young adults with cancer did not report more current or past symptoms of internalizing psychopathology.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%