Childhood Cancer Survivorship

Schulte, Fiona; Forbes, Caitlin; Wurz, Amanda; Patton, Michaela; Russell, K. Brooke; Pluijm, Saskia M F; Krull, Kevin R.

doi:10.1016/j.pcl.2020.07.004

Cited by 10 publications

(9 citation statements)

References 118 publications

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“…Not only physical functioning was lower in relapsed patients (as measured with the SF-12), but also their personal perspective on it after a cancer treatment was less positively influenced than in non-relapsed patients (as measured with the body and health scale of the IOC-CS). Survivors of childhood cancer in general might show lower levels of physical activity and increased risky health behavior [ 39 ]. Patients who relapsed or experienced a SN, might be physically challenged even more than non-relapsed patients, as they receive more treatments with physical side effects.…”

Section: Discussionmentioning

confidence: 99%

“…Worrying about the disease and its impact could be challenging for specific ALL patients. Some might face more socializing adjustment difficulties [ 39 ]. More specifically, we encountered that older (≥6 years) and non-relapsed patients in our cohort demonstrated a more positive impact on socializing than younger and relapsed patients, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies

Sleurs

Musoro

Rowsell

et al. 2021

Cancers

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Background: due to increasing survival rates in childhood acute lymphoblastic leukemia (ALL), the number of survivors has been expanding. A significant proportion of these survivors can experience long-term emotional and psychosocial problems. However, the exact risk factors remain inconclusive. We investigated potential risk factors for decreased daily life quality and life challenges in long-term childhood ALL survivors enrolled between 1971 and 1998 in EORTC studies. Methods: self-report questionnaires were collected from 186 survivors (109 females; mean age at diagnosis 5.62 years, range 0.2–14.7; median time since diagnosis of 20.5 years (12.9–41.6)), including the Short-Form Health Survey (SF-12) and Impact of Cancer-Childhood Survivors (IOC-CS). Multivariable linear regression models were used to assess the impact of gender, age at diagnosis, relapse/second neoplasm, National Cancer Institute (NCI) risk group and cranial radiotherapy on 2 subscales of the SF-12 (physical and mental health) and five subscales of the IOC-CS (life challenges, body and health, personal growth, thinking and memory problems and socializing). Results: mental component scores of SF-12 were not significantly associated with any risk factor. Physical component scores were lower in relapsed, irradiated and NCI high-risk patients. Regarding IOC-CS negative impact subscales, life challenges was more negatively impacted by cancer in female, younger (i.e., <6 years) and relapsed patients. Regarding the positive impact scales, personal growth was more positively impacted in relapsed patients, whereas body and health, and socializing, were less positively impacted in these patients, compared to non-relapsed patients. Socializing was more positively impacted in older patients (>6 years). Conclusions: this study demonstrates that long-term outcomes can be both adverse and positive, depending on the patient’s demographic and clinical characteristics. Younger, female, and relapsed patients might encounter more life challenges years after their disease, while physical challenges could occur more often in relapsed and high-risk patients. Finally, the positive effect on socializing in the older patients sheds new light on the importance of peer interactions for this subgroup. Specific individual challenges thus need specialized support for specific subgroups.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies

Sleurs

Musoro

Rowsell

et al. 2021

Cancers

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“…Care should not be limited to the physical and cognitive aspects of the disease but should also focus on the most optimal psychosocial functioning of the patient such as autonomy and social contacts with peers [ 17 ]. Knowledge about possible delay in the psychosocial development enables health care providers to aim for the most favorable psychosocial functioning of patients and survivors and to provide timely and relevant interventions.…”

Section: Introductionmentioning

confidence: 99%

Psychosocial developmental milestones of young adult survivors of childhood cancer

Maurice‐Stam

2022

Support Care Cancer

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Purpose The study aimed to compare the psychosocial development of young adult survivors of childhood cancer (YACCS) with a norm group of young adults from the general population. Methods From 2017 to 2020, 558 YACCS (18–30 years, 51% female, 10.9% CNS cancer) who participated in the Dutch Childhood Cancer Survivor Study (DCCSS) LATER cohort (diagnosed 1963–2001) part 2 completed the Course of Life Questionnaire (CoLQ), assessing the achievement of milestones. Items were grouped into the scales autonomy, psychosexual, and social development. Differences between YACCS and norm group were examined with ANOVA and Cohen’s d (CoLQ scales) and with logistic regression analysis and odds ratio (OR) (CoLQ items), for the total group and YACCS of CNS cancer. Results The total group of YACCS did not report a less favorable psychosocial development than the norm group. YACCS of CNS cancer scored lower than the norm group (p < 0.001) on the scales autonomy (d = − 0.36) and psychosexual (d = − 0.46). Additionally, on half of the items of autonomy (0.25 ≤ OR ≤ 0.34), psychosexual (0.30 ≤ OR ≤ 0.48), and social (0.23 ≤ OR ≤ 0.47) development, YACCS of CNS cancer were less likely (p < 0.01) than the norm group to have achieved the milestones. Conclusion Overall, psychosocial development of YACCS was as favorable as the norm, but YACCS of CNS cancer were at risk of an unfavorable psychosocial development in all domains. Monitoring psychosocial development should be included in the standards of psychosocial care, especially for CNS cancer patients and survivors, to be able to trace delay. Personalized interventions should be offered to improve the psychosocial development in an early stage.

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“…Further, there is an estimated >500,000 survivors of childhood cancer in North America (Robison and Hudson, 2014). The most common forms of childhood cancer include leukemias, brain cancers, and solid tumour (Steliarova-Foucher et al, 2017;Siegel et al, 2021) Survivors of childhood cancer may be especially susceptible to the impacts of COVID-19 (Forster and Schulte, 2021) due to chronic health conditions, known as late effects, that stem from their cancer treatment (Schulte et al, 2020). These include health concerns that are known to increase risk of a more severe course of COVID-19, including pre-existing cardiac issues, pulmonary disorders, obesity, and diabetes (Neville et al, 2006;Brabant et al, 2012;Ward et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

The Perceived Impact of COVID-19 on the Mental Health Status of Adolescent and Young Adult Survivors of Childhood Cancer and the Development of a Knowledge Translation Tool to Support Their Information Needs

et al. 2022

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BackgroundAdolescent and young adult (AYA; 13 to 39 years) survivors of childhood cancer may be especially vulnerable to physical health and mental health concerns during the pandemic. We investigated the impact of COVID-19 on the mental health status of AYA survivors (Aim 1) and shared tailored, evidence-based health-related information on COVID-19 (Aim 2).MethodsBetween May and June 2020, participants completed a cross-sectional online survey assessing their cancer history, current mental health status, and their COVID-19 information needs.ResultsNinety-four participants (78 females, 13 males, 2 non-binary) with a mean age of 26.9 years (SD = 6.2) were included in the final sample. Participants reported residing from 10 countries and 94% identified as White. Nearly half of the participants (49%) described their mental health status as worse now than before the pandemic. Thirty-nine participants (41%) that indicated their current mental health status was tied to fears/worries about their past cancer and treatment experienced a higher level of anxiety and PTSS than those who did not report the same. Most participants (77%) had not received any information related to the potential risks of COVID-19 and expressed an interest in receiving this information. In response, an infographic detailing recommended strategies for coping with mental health problems in the pandemic, along with preliminary study findings, was developed.DiscussionAYA survivors reporting their mental health status was linked to their past cancer experienced poorer mental health. There is a value to educating survivors on their potential health risks, but accounting for their perceived mental health vulnerabilities should be considered when disseminating knowledge. The use of an infographic is a unique contribution towards the development of innovative and personalized means of sharing health education to this vulnerable yet resilient group. This research on the mental health status of AYA survivors very early in the pandemic informs continued initiatives investigating the rapidly changing nature of how COVID-19 may impact AYA survivors today and in the future.

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Childhood Cancer Survivorship

Cited by 10 publications

References 118 publications

Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies

Sociodemographic and Medical Determinants of Quality of Life in Long-Term Childhood Acute Lymphoblastic Leukemia Survivors Enrolled in EORTC CLG Studies

Psychosocial developmental milestones of young adult survivors of childhood cancer

The Perceived Impact of COVID-19 on the Mental Health Status of Adolescent and Young Adult Survivors of Childhood Cancer and the Development of a Knowledge Translation Tool to Support Their Information Needs

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