Long-Term Selection for Rapid Gain in Mice II. Correlated Changes in Reproduction1

Barria, Nelson; Bradford, G. E.

doi:10.2527/jas1981.524739x

Cited by 14 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Besides, a decrease in fertility is a common observation in selection experiments for increased body weight (B RADFORD , 1971 ;F RAHM & BROWN, 1975 ;B ARRIA & B RADFORD , 1981). That effect was detected in our experiment in the last generations (14 and 15).…”

Section: Reproductionsupporting

confidence: 54%

See 1 more Smart Citation

Direct and correlated responses to selection for large and small 6-week body weight in mice

Bayón¹,

Fuente²,

Primitivo³

1987

Genetics Selection Evolution

View full text Add to dashboard Cite

Section: Reproductionsupporting

confidence: 54%

“…In terms of practical breeding it seems, as indicated by B ARRIA & B RADFORD (1981), that intermediate sizes are more efficient reproductively than extremely large sizes.…”

mentioning

confidence: 96%

Direct and correlated responses to selection for large and small 6-week body weight in mice

Bayón¹,

Fuente²,

Primitivo³

1987

Genetics Selection Evolution

View full text Add to dashboard Cite

“…Siewerdt et al (1999) also found that females from the high-growth background lines TM and NM had reproductive advantages over females from control background lines TC and NC. Previous studies have shown that selection for large body size increases ovulation rate, but prenatal survival and fertility rates are often reduced (Fowler & Edwards, 1960 ;Land, 1970 ;Barria & Bradford, 1981).…”

Section: (Ii) Selection Background Differencesmentioning

confidence: 99%

Correlated responses to selection for large body size in oMt1a-oGH transgenic mice: reproductive traits

et al. 2000

View full text Add to dashboard Cite

Correlated responses in female reproductive performance were evaluated following short-term selection within full-sib families for increased 8-week body weight in two replicates of four lines of mice: two ovine metallothionein-ovine growth hormone (oMt1a-oGH) transgene-carrier lines, one from a high-growth background (TM) and one from a control background (TC), and two non-transgenic lines, one from each of these genetic backgrounds (NM and NC, respectively). A fifth line (CC), not containing the transgene, served as a randomly selected control. The initial frequency of the oMt1a-oGH transgene construct in the TM and TC lines was 0.5. The frequency of transgenic females sampled at generations 7 and 8 of selection was 84.0% and 6.1% in the TC and TM lines, respectively. No significant female infertility differences were detected between transgene-carrier and non-transgenic lines or between transgenic and non-transgenic mice within carrier lines, whereas high-growth background lines had a higher infertility than control background lines (P < 0.05). Correlated responses in the TC transgene-carrier line were suggestive of reduced reproductive performance as indicated by increased post-implantation mortality (P < 0.05), number of dead fetuses plus implants (P < 0.05), and loss of fetuses from day 16 to parturition (P < 0.001). For the first two traits, the negative correlated responses were accounted for by the reduced performance of transgenic compared with non-transgenic females. Embryos carrying the transgene may also have a lower viability. In contrast, the NC non-transgenic line did not exhibit reduced reproductive performance for these traits. The low frequency of the transgene in the high-growth background TM line was associated with reduced fitness and a lower additive effect for 8-week body weight compared with the control background TC line.

show abstract

“…Il existe plusieurs hypothèses pour expliquer cette dégradation ; Barria & Bradford, 1981). Les effets pléiotropiques ou les effets induits par un écart à un poids adulte optimum jouent un rôle prirn,ordial.…”

Section: Caractères Mesurésunclassified

Sélection sur la vitesse de croissance post-sevrage chez le lapin

Rochambeau¹,

Fuente²,

Rouvier³

et al. 1989

Genet Sel Evol

View full text Add to dashboard Cite

On a effectué une expérience de sélection massale sur la vitesse de croissance entre le sevrage (30 j) et 77 j dans une souche de lapin. La souche sélectionnée se composait de 12 mâles et 60 femelles pendant les 4 premières générations puis de 8 mâles et 40 femelles pendant les 4 suivantes. La souche témoin se composait aussi de 8 mâles et de 40 femelles. On a réalisé une intensité de sélection de 0,95. La vitesse de croissance postsevrage est améliorée de 6,9 g pour 8 générations, soit un progrès de 0,83 g par génération. L'héritabilité réalisée est égale à 0,23. Pour une augmentation d'un g de la vitesse de croissance post-sevrage, on observe une diminution de 0,10 du nombre de lapins vivants à la naissance par portée. Simultanément, le nombre de lapins vivants à 77 j produits par femelle mise à la reproduction a tendance à diminuer. Cette réduction de la fitness est due principalement à une diminution du nombre de femelles ayant fait au moins une portée avec un lapin vivant à 77 j. lapin -sélection -vitesse de croissance post-sevrage -taille de portée -fltness Summary -Selection experiment for post-weaning growth rate in rabbits. A selection experiment was made on the growth rate between weaning (30 days) and 77 days in a rabbit strain. There were 12 bucks and 60 does in the selected strain during the first 4 generations, then 8 bucks and l,0 does during the next 4 generations. There were 8 bucks and 40 does in the control strain. Selection intensity was 0.95. The response in post-weaning growth rate was 6.9 g after 8 generations, i.e. 0.83 g per generation. The realized heritability was 0.23. The increase in post-weaning growth rate was accompanied b an increase in 77-days body weight (58 g) and by a decrease in litter size at birth (-0.10! At the same time, the number of rabbits alive at 77 days per reproductive doe decreased. The main reason for the decrease of fitness was a decrease in the number of does with at least one rabbit alive at 77 days. rabbit -selection -post-weaning growth rate -litter size -fitness

show abstract

Long-Term Selection for Rapid Gain in Mice II. Correlated Changes in Reproduction1

Cited by 14 publications

References 0 publications

Direct and correlated responses to selection for large and small 6-week body weight in mice

Direct and correlated responses to selection for large and small 6-week body weight in mice

Correlated responses to selection for large body size in oMt1a-oGH transgenic mice: reproductive traits

Sélection sur la vitesse de croissance post-sevrage chez le lapin

Contact Info

Product

Resources

About