Long‐term safety and efficacy of methotrexate in patients with palindromic rheumatism

Sheng‐Kai, Kevin; Liu, Chien‐Te; Kao, Wei‐Chiao; Lee, Yung‐Heng

doi:10.1111/1756-185x.14420

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…Lastly, we are interested in the possibility of utilizing ultrasound to diagnose other inflammatory arthritis or autoimmune diseases and their comorbidities, [14][15][16][17][18] such as ankylosing spondylitis (AS) 19 or psoriatic arthritis (PsA), [20][21][22][23] juvenile idiopathic arthritis, 24,25 osteoarthritis, 26,27 or fibromyalgia. 28 The early signs of AS often appear as enthesis inflammation, 29,30 which may be detected by power Doppler ultrasound (PDUS) through the presence of bone erosion, pathological structural changes, and thickening of the tendon at the site of insertion.…”

Section: Ultrasound For Ankle and Foot Pathologies In Early Rheumatoi...mentioning

confidence: 99%

Ultrasound for ankle and foot pathologies in early rheumatoid arthritis

et al. 2023

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Section: Ultrasound For Ankle and Foot Pathologies In Early Rheumatoi...mentioning

confidence: 99%

Ultrasound for ankle and foot pathologies in early rheumatoid arthritis

et al. 2023

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“…Not until recently did the spondyloarthritis (SpA) eventually gain its name rectification after vigorous discussion in the rheumatology community 1 . As a member of the inflammatory rheumatic disease family causing arthritis,2‐6 spondyloarthritis is not a single type of disease; instead, it indicates a spectrum of rheumatic diseases that share similar clinical features. The most common feature is inflammatory back pain.…”

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confidence: 99%

Imaging modalities for the diagnosis of axial spondyloarthritis

2023

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“…Therefore, stratification or adjustment of treatments and medications may clarify whether the observed results were caused by the disease or were modified by the use of medications in these patients. Such analyses could provide evidence regarding the safety and efficacy of NSAIDs, steroids, and biologic disease-modifying antirheumatic drugs (DMARDs) 8,16,32,34 in patients with AS, TKA, DISH, or CAD, which could improve patient care and patient education 6,35,36 on drug safety. [37][38][39][40] Last but not least, as this was a cross-sectional study, without longitudinal data, as in cohort studies, [41][42][43] acquired during follow-ups, [44][45][46] the causal effect of inflammation on the observed radiographic findings may not be ascertained.…”

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Aortic‐vertebral interaction in inflammation

et al. 2023

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Aortic-vertebral interaction in inflammationDear editor, We read with great interest the article by Chen et al., in which the aortic-vertebral interaction was proposed in the context of inflammation. 1 The study suggested that inflammation may promote ossification and was linked to a large aorta ipsilateral ratio of the osteophytes. This topic has significant clinical relevance, and future cohort studies covering various aspects are needed to further validate the findings in this study.First, it is important to note that baseline demographics and comorbidities may have influenced the study observations. At Shanghai Renji Hospital between 2013 and 2021, the percentage of male participants in the Takayasu's arteritis (TKA) group, the ankylosing spondylitis (AS) group, the coronary artery disease (CAD), and the diffuse idiopathic skeletal hyperostosis (DISH) group were 38.7%, 65.4%, 70%, and 60%, respectively, compared to 50% in the healthy controls (HC). Male sex may have been a potential confounder, as previous research has suggested that males are at a greater risk of AS, CAD, and DISH 2 than females. Therefore, adjusting or stratifying for sex 3 could provide insights into whether male sex was a mediator or a confounder in the causal relationship between inflammation and radiographic phenotypes. In addition, since inflammation was proposed as a key component in this study, it would be valuable to consider the presence of inflammatory diseases or autoimmune diseases 4-7 such as rheumatoid arthritis, 8-12 psoriasis, 13-15 psoriatic arthritis, [16][17][18] Sjogren's syndrome, 19,20 fibromyalgia, 21,22 periodontitis, 22-28 or other diseases with osteophytes such as osteoarthritis, 23,29,30 as potential effect modifiers.The second issue to be addressed is the potential impact of unmeasured confounders on the observed findings. For example, the article did not report on the common medications used to manage AS and TKA, which are known to reduce C-reactive protein (CRP) levels and heterotopic ossification. These medications include nonsteroidal anti-inflammatory drugs (NSAIDs), which are commonly used to manage AS and recommended as a prophylactic regimen for postoperative heterotopic ossification. 31,32 Similarly, the use of tumor necrosis factor (TNF) alpha inhibitors and interleukin-17 inhibitors may inhibit tenascin-C from affecting aorta-vertebrae remodeling. 1Additionally, low doses of corticosteroids have been found to significantly reduce CRP levels, 33 which can also affect the aorta ipsilateral ratio or observed radiographic progression. Therefore, stratification or adjustment of treatments and medications may clarify whether the observed results were caused by the disease or were modified by the use of medications in these patients. Such analyses could provide evidence regarding the safety and efficacy of NSAIDs, steroids, and biologic disease-modifying antirheumatic drugs (DMARDs) 8,16,32,34 in patients with AS, TKA, DISH, or CAD, which could improve patient care and patient education 6,35,36 on drug safety...

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Long‐term safety and efficacy of methotrexate in patients with palindromic rheumatism

Cited by 3 publications

References 10 publications

Ultrasound for ankle and foot pathologies in early rheumatoid arthritis

Ultrasound for ankle and foot pathologies in early rheumatoid arthritis

Imaging modalities for the diagnosis of axial spondyloarthritis

Aortic‐vertebral interaction in inflammation

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