Long-term Results of Spinal Cord Injury Therapy Using Mesenchymal Stem Cells Derived From Bone Marrow in Humans

Park, Jin Hoon; Kim, Dae Yul; Sung, Inn Young; Choi, Gyong Hyo; Jeon, Min Ho; Kim, Kwang Kuk; Jeon, Sang Ryong

doi:10.1227/neu.0b013e31824387f9

Cited by 161 publications

(111 citation statements)

References 59 publications

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“…[54] Omurilik yaralanması üzerine, Park ve ark. [55] 2012 yılında yaptıkları bir çalımada; 10 hastaya intramedüller olarak MKH vererek uzun dönem sonuçlarını de¤erlendirmilerdir. Hastalardan MKH'ler kemik ili¤inden izole edilmi, dört hafta boyunca kültüre edilerek ço¤altılmıtır.…”

Section: Self-renewal (Kendini Yenileyebilme)unclassified

Stem cells; mesenchymal stem cells and current clinical applications

Tekeli¹

2016

FNG & Bilim Tıp Transplantasyon Dergisi

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Stem cells are defined as a type of cell that have the features of self-renewal, unlimited proliferation capacity, potential of differentiation into other cell types and ability to repair damaged structure when given to damaged tissue. Stem cells are preferred for regenerative medical applications because of their abundance, being easily obtained, ability to proliferate by differentiating into many cell types and being transplantable safely and effectively to recipients. In this review, we introduce mesenchymal stem cells as one of the most important sources of stem cells that have clinical applications and give examples of their usage areas in the clinic and of studies.Keywords: Clinical application; mesenchymal stem cells; stem cell. Stem cells; mesenchymal stem cells and current clinical applications ÖZKök hücreler; kendilerini yenileyebilme, sınırsız çoğalabilme, kendilerinden başka hücrelere farklılaşabilme, hasarlı dokuya verildiğinde hasarlı yapıyı onarabilme özellikleri ile tanımlanan hücre tipidir. Kök hücreler bol miktarda bulunmaları, kolay elde edilebilmeleri, birçok hücre tipine farklılaşarak çoğalabilmeleri, alıcılara güvenli ve etkin bir şekilde nakledilebilmeleri nedeniyle rejeneratif tıp uygulamalarında tercih edilmektedir. Bu derlemede, klinikte uygulamaları bulunan ve en önemli kök hücre kaynaklarından biri olan mezenkimal kök hücreler tanıtılacak, klinikteki kullanım alanları ve çalışmalardan örnekler verilecektir.

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Section: Self-renewal (Kendini Yenileyebilme)unclassified

Stem cells; mesenchymal stem cells and current clinical applications

Tekeli¹

2016

FNG & Bilim Tıp Transplantasyon Dergisi

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“…The studies using OEC used open surgical intervention Lima et al (35), Mackay-Sim et al (49); while Feron et al (34) used OEC as a cellular graft injected directly into the spinal cord under microscopic guidance . However MSC or MNC implantation using surgical procedure did not report superior results justifying the invasive procedure Abdelaziz et al (40), Chernyck et al (37) , Park et al (45). The use of intra-arterial route is limited due to the technical difficulty.…”

Section: Route Of Injectionmentioning

confidence: 99%

“…The cell dose used in the published studies varied according to the cell type used. Intrathecally-injected MSCs varied from 1X10 6 /kg used by Pal et al (48) to 4X 10 7 used by Park et al (45).…”

Section: Cell Dosementioning

confidence: 99%

Stem Cell Transplantation for Traumatic Spinal Cord Injury: What Have We Learned from Previous Experience

Elhawary¹,

Wagih²,

Essam³

et al. 2015

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Abstract:Spinal cord injuries represent one of the most devastating illnesses that can affect the human body. Before the advent of the regenerative medicine era, it was regarded as an untreatable condition. Stem cell plasticity and translational medicine research open a new window of hope for this category of patients. Clinical trials of stem cell therapy for spinal cord injuries are now more than a decade old. However, the diversity of clinical trial design, cell type, dose and route of injection, make it extremely difficult to draw decisions from these previous experience. This review tries to collect as much evidence as we can from previous studies in order to suggest paths for future research in this setting.

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“…These cells have been shown to secrete neurotrophic factors, but they do not seem to be able to replace lost neurons. A recent study found that three of ten patients with cervical spinal injury who received their own mesenchymal stem cells -progenitor cells that differentiate to form bone and cartilage -had more power in their upper limbs and less trouble performing daily activities than they did before receiving the stem cells 6 .…”

Section: Inducing Optionsmentioning

confidence: 99%