1987
DOI: 10.1016/s0161-6420(87)33456-6
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Long-term Results of Proton Beam Irradiated Uveal Melanomas

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Cited by 206 publications
(83 citation statements)
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“…Long term local control rates of 95% and greater have been reported by Castro et al 1 and Gragoudas et al 2 As of December 2002, over 3000 uveal melanoma patients have been treated at MGH with proton beam radiotherapy ͑PBRT͒. 5,6 The 5 and 15 yr local control rates of 97% and 95%, respectively, [6][7][8][9] and overall survival rate of 80% were reported, which is comparable to the survival rates reported for enucleation.…”
Section: Introductionsupporting
confidence: 59%
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“…Long term local control rates of 95% and greater have been reported by Castro et al 1 and Gragoudas et al 2 As of December 2002, over 3000 uveal melanoma patients have been treated at MGH with proton beam radiotherapy ͑PBRT͒. 5,6 The 5 and 15 yr local control rates of 97% and 95%, respectively, [6][7][8][9] and overall survival rate of 80% were reported, which is comparable to the survival rates reported for enucleation.…”
Section: Introductionsupporting
confidence: 59%
“…[1][2][3][4] Charged particle beams travel through tissue in nearly straight lines with minimum multiple scattering. The deposition of energy increases along the path of the charged particle ending with a sharp maximum, known as the Bragg peak, at the end of the particle range.…”
Section: Introductionmentioning
confidence: 99%
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“…Since 1986, partial ocular decompression was routinely performed, either before the dissection of the scleral flap by three port vitrectomy (WSF), or after preparation of the flap, via a single sclerotomy and without infusion (BED). The deep sclera and choroid were divided some [3][4][5] used in conjunction with Cox's proportional local resection was 50 years (SD 13-3; range hazards model to identify those factors influenc-19-78). A small minority of patients were known ing event rates most profoundly.…”
Section: Surgical Techniquementioning
confidence: 99%
“…1,3,5 No biopsies confirming the malignant nature of the lesion were performed in this series of iris lesions, but the majority of patients nevertheless presented documented growth of a tumour arising on a pre-existing lesion, while all other patients presented a tumour whose initial clinical characteristics were highly suggestive of the diagnosis in agreement with the majority of authors, 2,3,9 and according to the criteria defined above (essentially size). Conservative management by irradiation was therefore proposed on this body of evidence, by analogy with conservative radiotherapy [10][11][12][13][14][15][16][17] performed for ciliary and choroidal melanomas, in order to avoid the metastasis and preserve a functional eye. Proton therapy is a modality of conformal radiotherapy, which uses a proton beam whose ballistic properties allow localised delivery of energy to the target volume.…”
Section: Discussionmentioning
confidence: 99%