Long-term results of arterial allograft below-knee bypass grafts for limb salvage: A retrospective multicenter study

Abstract

AA leads to an acceptable limb salvage rate but poor patency rates. A randomized trial that will compare AAs and polytetrafluoroethylene should be undertaken.

Cryopreserved Human Allografts for the Reconstruction of Aortic and Peripheral Prosthetic Graft Infection

“…Other series reported similar results. 21 ) However, most of these interventions were distal revascularization for limb salvage, which represents the worst setting for any type of vascular conduit. It is impossible to draw definitive conclusions regarding the reasons for our good results, especially because we needed to target a more distal vessel in almost all cases of infected peripheral bypass; further, we did not have long-term follow-up, and the cohort mixed aortic and peripheral reconstructions.…”

“…Persistent or recurrent infections have been reported ranging from 5% to 10% post CHA reconstructions mainly because of infections extending to the adjacent tissues. 7 – 10 , 13 , 15 – 21 , 24 ) To minimize this potential complication, we used a multimodal approach: complete original graft removal, extra-anatomical CHA positioning (peripheral cases) to avoid an extensively contaminated bed, aggressive peri-prosthetic debridement of contaminated tissues, coverage of the CHA with a pediculated omentum flap (abdominal cases) or a sartorius myoplasty (peripheral cases), close follow-up, and prolonged multiple anti-microbial therapy. 8 , 9 ) In our opinion, this aggressive management has been effective.…”

A novel approach of arteriovenous fistula formation in cultivation of an arm vein for use in infrainguinal surgical bypass grafting

“…Secondary patency rates for human umbilical vein are 29% at 3 years 8 and 57% to 76% at 5 years 9, 10. Arterial cadaveric allografts have 3-year secondary patency rates of 42.1% compared with 25.9% at 5 years 11 . The 1-year secondary patency rate for cryopreserved vein allografts from cadavers is 42% 12 .…”

Non-Invasive Biomechanical Evaluation of Implanted Human Cryopreserved Arterial Homografts

“…In the lack of suitable autologous materials, cryopreserved/defrosted arteries (cryografts) could be used. 1,30 However, the post-thaw functional recovery of cryografts could be associated with an altered biomechanical performance. 1,5,33 Related with this, we recently demonstrated, in in vitro studies, that the techniques of cryopreservation used in our national tissue bank do not significantly affect the biomechanical behavior of human veins and elastic and muscular arteries in any detrimental way.…”

“…1,30 However, the post-thaw functional recovery of cryografts could be associated with an altered biomechanical performance. 1,5,33 Related with this, we recently demonstrated, in in vitro studies, that the techniques of cryopreservation used in our national tissue bank do not significantly affect the biomechanical behavior of human veins and elastic and muscular arteries in any detrimental way. 9,10,12 In addition, we demonstrated, in pre-implant studies, that cryopreserved arteries would allow reducing the BM with native arteries from potential recipients.…”