Long term results of a randomized study by the Swedish Melanoma Study Group on 2-cm versus 5-cm resection margins for patients with cutaneous melanoma with a tumor thickness of 0.8-2.0 mm

Cohn‐Cedermark, Gabriella; Rutqvist, Lars Erik; Andersson, Ronny; Breivald, Mats; Ingvar, Christian; Johansson, Hemming; J�nsson, Per-Ebbe; Krysander, Lennart; Lindholm, Christer; Ringborg, Ulrik

doi:10.1002/1097-0142(20001001)89:7<1495::aid-cncr12>3.0.co;2-d

Cited by 265 publications

(102 citation statements)

References 13 publications

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“…Consensus was achieved regarding data to be collected on patients with newly diagnosed cutaneous melanoma. Studies focused on excision margins, 1,2 head and neck melanomas, 3,4 chemotherapy, 5 and limb perfusion 6 have been published previously. Sweden, with 8.8 million inhabitants, is divided into 6 health care regions.…”

Section: Discussionmentioning

confidence: 99%

Invasive cutaneous malignant melanoma in Sweden, 1990–1999

Lindholm¹,

Andersson²,

Dufmats³

et al. 2004

Cancer

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BACKGROUND The objective of the current study was to compile prospective, population‐based data on cutaneous invasive melanomas in Sweden during the period from 1990 to 1999, to describe and analyze survival data and prognostic factors, and to make comparisons with previously published Swedish and international data. METHODS Twelve thousand five hundred thirty‐three patients, which included 97% of all registered melanomas in Sweden, were included and described. Among these, 9515 patients with clinical Stage I and II melanoma were included in an analysis of survival and in a univariate analysis, and 6191 patients were included in a multivariate analysis of prognostic factors. RESULTS There was no significant change in melanoma incidence during 1990–1999. Favorable prognostic factors were found, especially in younger and female patients, resulting in a relative 5‐year survival rate of 91.5%. In the multivariate analysis, significant factors that had a negative effect on survival were Clark level of invasion, Breslow thickness, ulceration, older patient age, trunk location, greatest tumor dimension, nodular histogenetic type, and male gender. CONCLUSIONS During the period from 1990 to 1999, the 5‐year survival of patients with malignant melanoma in Sweden was better compared with the previously reported rates in published, population‐based studies from Sweden, probably as a result of better secondary prevention due to better knowledge and awareness by both patients and the medical profession. The more favorable prognostic factors and the change in melanoma location found in younger patients, compared with earlier reports, may reflect changes in clothing as well as tanning habits; however, a decrease also was found in Clark Level II and thin melanomas for the same patient group. The authors concluded that further improvements can be achieved with better access to health care and with the use of early melanoma detection campaigns. Cancer 2004. © 2004 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Invasive cutaneous malignant melanoma in Sweden, 1990–1999

Lindholm¹,

Andersson²,

Dufmats³

et al. 2004

Cancer

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“…[1][2][3][4][5][6] The definitions of narrow and wide margins varied from 1 to 2 cm for narrow margins and 3 to 5 cm for wide margins. The depth of melanoma also varied between studies, from low-risk, thin melanomas (<1 mm) to higher-risk, thick melanomas (>4 mm).…”

Section: Peripheral Marginsmentioning

confidence: 99%

Mayo Clinic Consensus Recommendations for the Depth of Excision in Primary Cutaneous Melanoma

Grotz

Markovic

Erickson

et al. 2011

Mayo Clinic Proceedings

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“…Cohn-Cedermark et al reported the results of the Swedish Melanoma Study Group trial, which evaluated 989 patients with primary melanomas between 0.8 and 2.0 mm thick. 87 Patients were randomly allocated to excision with a 2-cm or a 5-cm margin. There were no statistically significant differences in local recurrence rates or survival between the 2 arms.…”

Section: Surgical Treatment Of Melanomamentioning

confidence: 93%