State of the science 60th anniversary review

Demierre, Marie‐France; Sabel, Michael S.; Margolin, Kim; Daud, Adil; Sondak, Vernon K.

doi:10.1002/cncr.23643

Cited by 13 publications

(7 citation statements)

References 196 publications

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“…It is well known that melanoma has a wide spectrum of histological features which mimic epithelial, hematological, mesenchymal and neural tumors, and when necessary immunohistochemistry is the primary tool to establish the correct diagnosis (14-16,30). Yu et al (17) studied the expression of melanocytic differentiation markers in 6 primary OM.…”

Section: Discussionmentioning

confidence: 99%

Primary oral melanoma: A histopathological and immunohistochemical study of 22 cases of Latin America

Andrade¹,

Toral-Rizo²,

León³

et al. 2012

Med Oral

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Objective: The aim of this study was to analyze the histopathological and immunohistochemical characteristics of 22 cases of primary oral melanomas (OM). Study Design: Twenty two cases of primary oral melanoma were analyzed by description of their histopathological features and immunohistochemical study using the antibodies S-100, HMB-45, Melan-A and Ki-67. Results: The mean age was 58 years and 14 cases were female. The main affected sites were the hard palate, followed by the upper gingiva. Microscopically, 15 cases presented level III of invasion, 2 cases were amelanotic and 13 showed a mixed epithelioid and plasmacytoid or spindle cells composition. Some cases showed necrosis, perivascular and perineural invasion. S-100 and HMB-45 were positive in all cases, but 3 cases were negative for Melan-A. The proliferative index with Ki-67 was high, with labeling index ranging from 15.51% to 63% of positive cells. Conclusion: S-100 and HMB-45 are more frequently expressed than Melan-A in primary oral melanomas and these markers are helpful to confirm the diagnosis. Key words:Oral melanoma, histopathology, immunohistochemistry.

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Section: Discussionmentioning

confidence: 99%

Primary oral melanoma: A histopathological and immunohistochemical study of 22 cases of Latin America

Andrade¹,

Toral-Rizo²,

León³

et al. 2012

Med Oral

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“…Despite advances in melanoma treatment [1-4], mortality from melanoma is still increasing [5]. Melanoma prevention and early detection represent the best approaches to survive [6].…”

Section: Introductionmentioning

confidence: 99%

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma

Bevelacqua

Candido

et al. 2012

Oncotarget

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NECL-5 is involved in regulating cell–cell junctions, in cooperation with cadherins, integrins and platelet-derived growth factor receptor, that are essential for intercellular communication. Its role in malignant transformation was previously described. It has been reported that transformation of melanocytes is associated with altered expression of adhesion molecules suggesting the potential involment of NECL-5 in melanoma development and prognosis. To shed light on this issue, the expression and the role of NECL-5 in melanoma tissues was investigated by bioinformatic and molecular approaches. NECL-5 was up-regulated both at the mRNA and the protein levels in WM35, M14 and A375 cell lines compared with normal melanocytes. A subsequent analysis in primary and metastatic melanoma specimens confirmed “in vitro” findings. NECL-5 overexpression was observed in 53 of 59 (89.8%) and 12 of 12 (100%), primary melanoma and melanoma metastasis, respectively; while, low expression of NECL-5 was detected in 12 of 20 (60%) benign nevi. A significant correlation of NECL-5 overexpression was observed with most of known negative melanoma prognostic factors, including lymph-node involvement (P = 0.009) and thickness (P = 0.004). Intriguingly, by analyzing the large series of melanoma samples in the Xu dataset, we identified the transcription factor YY1 among genes positively correlated with NECL-5 (r = 0.5). The concordant computational and experimental data of the present study indicate that the extent of NECL-5 expression correlates with melanoma progression.

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“…Os melanócitos são células que produzem e contém no citoplasma o pigmento melanina, localizadas na camada basal da epiderme, infundíbulo e região bulbar dos folículos pilosos, na coróide, leptomeninges e mucosas. As células precursoras dos melanócitos são os melanoblastos, que são células de origem neuroectodérmica, que migram a partir da crista neural do embrião para a pele, retina, meninges, mucosas oronasal e respiratória, entre a 12ª e 14ª semanas de vida intra-uterina (Erckon, 1993;Alonso et al, 2004, Demierre et al, 2008. Uma vez na derme, os melanoblastos sofrem maturação, dando origem a células precursoras de melanócitos (pré-melanócitos precoces e intermediários), que na epiderme diferenciam-se completamente para melanócitos (Alonso et al, 2004;Carlson et al, 2009).…”

Section: Melanomaunclassified

“…É por meio dessas expansões citoplasmáticas que organelas contendo melanina, conhecidas como melanossomos são transferidas dos melanócitos para os queratinócitos, no processo de pigmentação da epiderme. A melanina atua como importante filtro endógeno dos raios ultravioletas, sendo sintetizada pelos melanócitos, tendo a tirosina como precursor (Erckon, 1993;Jimbow et al, 1993;Alonso et al, 2004;Demierre et al, 2008;Tran et al, 2008;Carlson et al, 2009). A função dos melanócitos na mucosa oral ainda não é conhecida.…”

Section: Melanomaunclassified

“…Os estudos populacionais são realizados predominantemente em regiões desenvolvidas, como América do Norte e Europa, cuja incidência varia entre 13 e 21/100.000 habitantes e, sobretudo na Austrália, que possui a maior incidência no mundo com acometimento de cerca de 30 homens/100.000 e 24 mulheres/100.000 habitantes ao ano (Thompson et al, 2005;Demierre et al, 2008) Liang et al, 2006;Belagyi et al, 2006).…”

Section: Melanoma Cutâneounclassified

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Melanoma oral e sinonasal primario

Andrade¹

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State of the science 60th anniversary review

Cited by 13 publications

References 196 publications

Primary oral melanoma: A histopathological and immunohistochemical study of 22 cases of Latin America

Primary oral melanoma: A histopathological and immunohistochemical study of 22 cases of Latin America

Nectin like-5 overexpression correlates with the malignant phenotype in cutaneous melanoma

Melanoma oral e sinonasal primario

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