Long‐term results after treatment of periodontitis in patients with Papillon–Lefèvre syndrome: success and failure

Nickles, Katrin; Schacher, Beate; Ratka‐Krüger, Petra; Krebs, Mischa; Eickholz, Peter

doi:10.1111/jcpe.12120

Cited by 28 publications

(33 citation statements)

References 43 publications

(35 reference statements)

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“…Although diseases with polymorphonuclear neutrophil defects are rare, there are several reports on periodontal treatment strategies. The treatment has been empirical and without consistent success (26,142). Proposed treatment strategies include periodic professional cleaning once every 3 months, extraction of all deciduous teeth at least 6 months before the eruption of the first permanent tooth and periodontal treatment of the involved teeth (206).…”

Section: Role Of Polymorphonuclear Neutrophils In the Pathogenesis Ofmentioning

confidence: 99%

“…Replacing missing teeth in these medically compromised patients is a difficult task. Although successful implant therapy has been described, as in several patients with Papillon-Lef evre syndrome who adhered to the strict maintenance program (142), patients with polymorphonuclear neutrophil defects are at high risk for infectious complications. The risks for severe peri-implantitis with possible complications beyond the peri-implant tissues, such as submandibular abscesses (129), outweigh the benefits.…”

Section: Role Of Polymorphonuclear Neutrophils In the Pathogenesis Ofmentioning

confidence: 99%

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Polymorphonuclear neutrophils in periodontitis and their possible modulation as a therapeutic approach

Nicu¹,

Loos²

2016

Periodontology 2000

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The main focus of this review is polymorphonuclear neutrophilic granulocytes. Polymorphonuclear neutrophils play a pivotal role in normal host resistance to subgingival dental-plaque biofilm. Both hyper- and hypo-responsiveness of the immune system toward the microbial challenge in periodontitis have been described. We review polymorphonuclear neutrophil physiology with emphasis on the role of neutrophil functions and dysfunctions in periodontitis. Text boxes are given at the end of each subsection, which present the current knowledge on neutrophil-modulating agents as a potential therapeutic approach in periodontitis.

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Section: Role Of Polymorphonuclear Neutrophils In the Pathogenesis Ofmentioning

confidence: 99%

Section: Role Of Polymorphonuclear Neutrophils In the Pathogenesis Ofmentioning

confidence: 99%

Polymorphonuclear neutrophils in periodontitis and their possible modulation as a therapeutic approach

Nicu¹,

Loos²

2016

Periodontology 2000

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“…Oral manifestations-Severe destructive periodontitis can lead to early loss of primary and permanent teeth; however, various reports demonstrate that patients with PLS can be successfully treated and managed to include dental implants (Toygar et al, 2007;Veerabahu et al, 2011;Al Farraj AlDosari, 2013;Nickles et al, 2013). Toygar et al treated a young female with periodontal therapy, orthodontics, osseous augmentation, and implants with success and maintained her oral health after 13 years of follow-up (Toygar et al, 2007).…”

Section: Oral Diseasesmentioning

confidence: 99%

Periodontal and other oral manifestations of immunodeficiency diseases

2016

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The list of immunodeficiency diseases grows each year as novel disorders are discovered, classified, and sometimes reclassified due to our ever-increasing knowledge of immune system function. Although the number of patients with secondary immunodeficiencies (SIDs) greatly exceeds those with primary immunodeficiencies (PIDs), the prevalence of both appears to be on the rise probably because of scientific breakthroughs that facilitate earlier and more accurate diagnosis. Primary immunodeficiencies in adults are not as rare as once thought. Globally, the main causes of secondary immunodeficiency are HIV infection and nutritional insufficiencies. Persons with acquired immune disorders such as AIDS caused by the Human Immunodeficiency Virus (HIV) are now living long and fulfilling lives as a result of highly active antiretroviral therapy (HAART). Irrespective of whether the patient’s immune deficient state is a consequence of a genetic defect or is secondary in nature, dental and medical practitioners must be aware of the constant potential for infections and/or expressions of autoimmunity in these individuals. The purpose of this paper is to review the most common conditions resulting from primary and secondary immunodeficiency states, how they are classified, and the detrimental manifestations of these disorders on the periodontal and oral tissues.

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“…Aggregatibacter actinomycetemcomitans was also reported to have a significant role in the pathogenesis and progression of periodontal involvements in PLS patients. Several patients, however, were positive for other periodontal pathogens [19][20][21]. PLS-periodontitis was also reported to be associated with human herpesviruses [22].…”

Section: Papillon-lefévre Syndromementioning

confidence: 99%

Syndromes That Include Both Palmoplantar Keratoderma And Severe Periodontitis: A Review

Dababneh¹

2013

Dentistry

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Palmoplantar keratodermas (PPK) include a heterogeneous group of disorders with overlapping clinical features. The main aspect of PPK is thickening and hyperkeratosis of the palmar and plantar skin, that may be hereditary or acquired; diffuse, focal, or punctuate; and transgrediens or progrediens. PPKs are further distinguished by their mode of inheritance and by the presence of certain associated clinical features. Periodontitis was reported in association with more than one syndrome characterized by PPK. An extensively reported one is the Papillon-Lefévre syndrome (PLS) which is characterized by early onset of PPK and periodontitis affecting the primary and secondary dentitions. In addition to PLS, Haim-Munk, HOPP, Variant Carvajal and Weary-Kindler are other syndromes manifested by PPK and reported in association with severe periodontitis. Atypical cases of PLS were also reported, such as partial expression or a late presentation of the syndrome. The aim of this article is to critically review the literature concerned with Papillon-Lefévre syndrome in its typical and atypical clinical presentation, in addition to other syndromes manifested at the same time by PPK and severe periodontitis.Thorough history and medical examination, together with periodontal, dermatologic, and genetic counseling, are important to exclude other existing medical conditions or other syndromes that might need special attention and care.

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Long‐term results after treatment of periodontitis in patients with Papillon–Lefèvre syndrome: success and failure

Cited by 28 publications

References 43 publications

Polymorphonuclear neutrophils in periodontitis and their possible modulation as a therapeutic approach

Polymorphonuclear neutrophils in periodontitis and their possible modulation as a therapeutic approach

Periodontal and other oral manifestations of immunodeficiency diseases

Syndromes That Include Both Palmoplantar Keratoderma And Severe Periodontitis: A Review

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