Long-term results after surgical treatment of the dominant lung adenocarcinoma associated with ground-glass opacities

Bongiolatti, Stefano; Corzani, Roberto; Borgianni, Sara; Meniconi, Fabiola; Cipollini, Fabrizio; Gonfiotti, Alessandro; Viggiano, Domenico; Paladini, Piero; Voltolini, Luca

doi:10.21037/jtd.2018.07.21

Cited by 21 publications

(18 citation statements)

References 20 publications

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“…Regarding unresected GGNs, previous studies have shown that many lesions remained unchanged, but that a certain proportion increase in size. No relationship was found between the prognosis and progression of the unresected GGN in this study, which is in line with previous reports [15,16]. In order to reduce wasteful follow-up, we think that is necessary to screen patients and lesions that are likely to increase in size.…”

Section: Discussionsupporting

confidence: 90%

“…Several studies have reported similar results, showing that prolonged survival was generally achieved by anatomic resection of the DT and wedge resection of the accessible GGNs [11,[14][15][16]. As for OS and DFS, our results were similar to those of several previous studies.…”

Section: Discussionsupporting

confidence: 90%

“…As far as the lesion was concerned, we found that lesions that were larger in size were more likely to grow. In previous reports, the size of the DT and the proportion of the solid component were also associated with an increased risk of lesion growth [15,16]. When possible, resecting larger-sized lesions with the DT may be the most efficient approach.…”

Section: Discussionmentioning

confidence: 89%

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Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas

Hotta

Tsubata

Tanino

et al. 2020

J Cardiothorac Surg

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Background: Multiple synchronous ground glass nodules (GGNs) are known to be malignant, however, they tend to progress slowly. Multiple synchronous lesions in the same patient which show different characteristics must be treated individually. Methods: This was a retrospective review of 34 lung adenocarcinoma patients with multiple synchronous GGNs in an Asian population. One hundred twenty-seven single lung adenocarcinoma patients were included for comparison purposes. The follow-up period was 5 years for all patients. Results: The 5-year overall survival (OS) patients with multiple lesions did not differ from that of the patients with single lesions to a statistically significant extent (Single: 81.8% vs. Multiple: 88.2%, P = 0.3602). Dominant tumors (DTs) with a ground glass component and consolidation were divided into three categories based on the consolidation-to-tumor ratio on radiological imaging. No significant differences were observed among the three DT categories. Twenty-four patients had unresected GGNs, while a progression of the unresected GGN occurred in 10 of these cases. The OS and disease-free survival (DFS) curves of patients with and without GGN progression did not differ to a statistically significant extent (OS: 80% vs. 92.9%, P = 0.3870; DFS: 80% vs. 100%, P = 0.0977). Conclusions: The outcomes were best predicted by the stage of the DT. After surgery patients require a careful follow-up because unresected GGNs may show progression. At the same time, the increase in residual lesions and the appearance of new GGNs were not related to OS. The management of such patients should be determined according to the DT with the worst prognosis.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 89%

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Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas

Hotta

Tsubata

Tanino

et al. 2020

J Cardiothorac Surg

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“…7 Meanwhile, the widespread of implementation of computed tomography has resulted in a drastic increase in the detection of small pulmonary nodules presenting as ground glass opacities (GGOs). 8 Many of these GGOs are atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and sometimes invasive adenocarcinoma (IAC). 9 Surgical resection was reported to yield a 5-year survival rate of almost 100% for AAH, AIS, and MIA, which decreases substantially for IAC.…”

Section: Introductionmentioning

confidence: 99%

Genomic Landscape and Immune Microenvironment Features of Preinvasive and Early Invasive Lung Adenocarcinoma

Chao

Zhang

et al. 2019

Journal of Thoracic Oncology

120

108

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Background-Understanding the genomic landscape and immune microenvironment features of preinvasive and early invasive lung adenocarcinoma may provide critical insight and facilitate development of novel strategies for early detection and intervention. Methods-A total of 80 tumor tissue samples and 30 paired histologically normal lung tissue samples from 30 patients with adenocarcinoma in situ (AIS) (n = 8), minimally invasive adenocarcinoma (MIA) (n = 8), and invasive adenocarcinoma (IAC) (n = 14) were subjected to multiregion whole exome sequencing and immunohistochemistry staining for CD8 and programmed death ligand 1 (PD-L1).

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“…As far as the lesion was concerned, we found that lesions that were larger in size were more likely to grow. In previous reports, the size of the DT and the proportion of the solid component were also associated with an increased risk of lesion growth (15,16). When possible, resecting larger-sized lesions with the DT may be the most e cient approach.…”

Section: Discussionmentioning

confidence: 88%

Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas.

Hotta

Tsubata²,

Tanino

et al. 2020

Preprint

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Background: Multiple synchronous ground glass nodules (GGNs) are known to be malignant, however, they tend to progress slowly. Multiple synchronous lesions in the same patient which show different characteristics must be treated individually.Methods: This was a retrospective review of 34 lung adenocarcinoma patients with multiple synchronous GGNs in an Asian population. One hundred twenty-seven single lung adenocarcinoma patients were included for comparison purposes. The follow-up period was 5 years for all patients. Results: The 5-year overall survival (OS) patients with multiple lesions did not differ from that of the patients with single lesions to a statistically significant extent (Single: 81.8% vs. Multiple: 88.2%, P=0.3602). Dominant tumors (DTs) with a ground glass component and consolidation were divided into three categories based on the consolidation-to-tumor ratio on radiological imaging. No significant differences were observed among the three DT categories. Twenty-four patients had unresected GGNs, while a progression of the unresected GGN occurred in 10 of these cases. The OS and disease-free survival (DFS) curves of patients with and without GGN progression did not differ to a statistically significant extent (OS: 80% vs. 92.9%, P=0.3870; DFS: 80% vs. 100%, P=0.0977).Conclusions: The outcomes were best predicted by the stage of the DT. After surgery patients require a careful follow-up because unresected GGNs may show progression. At the same time, the increase in residual lesions and the appearance of new GGNs were not related to OS. The management of such patients should be determined according to the DT with the worst prognosis.

show abstract

Long-term results after surgical treatment of the dominant lung adenocarcinoma associated with ground-glass opacities

Cited by 21 publications

References 20 publications

Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas

Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas

Genomic Landscape and Immune Microenvironment Features of Preinvasive and Early Invasive Lung Adenocarcinoma

Comparative postoperative outcomes of GGN-dominant vs single lesion lung adenocarcinomas.

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