Background: We aimed to investigate the high-resolution computed tomography (HRCT) features of lepidic-predominant type and other pathological subtypes of early-stage (T1N0M0) invasive pulmonary adenocarcinoma appearing as a ground-glass nodule (GGN). Methods: We performed a retrospective analysis on clinical data and HRCT features of 630 lesions in 589 patients with pathologically confirmed invasive pulmonary adenocarcinomas presenting as pure GGN and mixed GGN [consolidation-to-tumor ratio (CTR), <0.5] from January to December 2019. All GGNs were classified as lepidic-predominant adenocarcinoma (LPA) and nonlepidic-predominant adenocarcinoma (n-LPA) groups. Univariate analysis was performed to analyze the difference of clinical data and HRCT features between the LPA and n-LPA groups. Multivariate analysis was conducted to determine the variables to distinguish the LPA from n-LPA group independently. The diagnostic performance of different parameters was compared using receiver operating characteristic curves. Results: In total, 367 GGNs in the LPA group and 263 GGNs in the n-LPA group were identified. In the univariate analysis, the CTR, mean computed tomography (CT) values, and mean diameters as well as mixed GGN, deep lobulation, spiculation, vascular change, bronchial change, and tumor–lung interface were smaller in the LPA group than in the n-LPA group (P < 0.05). Logistic regression model was reconstructed including the mean CT value, deep lobulation, and vascular change (P < 0.001), as well as CTR, spiculation, and bronchial change (P < 0.05). Area under the curve of the logistic regression model for differentiating LPA and n-LPA was 0.840 (76.4% sensitivity, 78.7% specificity), which was significantly higher than that of the mean CT value or CTR (both P < 0.05). Conclusions: HRCT features were helpful in differentiating lepidic-predominant type from other subtypes in early-stage GGN invasive pulmonary adenocarcinoma. The mean CT value of <−472.5 HU and CTR of <27.4% were highly suspected in lepidic-predominant invasive pulmonary adenocarcinoma.