Long‐Term‐Release GnRH Agonists Postpone Puberty in Domestic Cats

Abstract

The aim of this study was to assess the efficacy and safety of deslorelin acetate implants on domestic queen puberty postponement. Thirty, 114.4 ± 12.7 days old, 1.5 ± 0.1 kg prepubertal crossbred female cats were included in this study. The animals were kept under a positive photoperiod and randomly assigned to deslorelin acetate 4.7 mg SC implants (n = 15) or to a non-treated control group (n = 15). The queens were followed up daily and weighed weekly until puberty. Vaginal cytology was also carried out three times a week. Puberty was diagnosed by the presence of the typical oestrous behaviour and vaginal cytology findings. At puberty, ovariectomy was performed and the gonads grossly described. Age (281.2 ± 21.6 vs 177.8 ± 10.8; p < 0.01) but not weight (2.6 ± 0.1 vs 2.5 ± 0.1; p > 0.1) at puberty differed between the deslorelin and control groups, respectively. One deslorelin-treated female showed an oestrous response and another showed clinical signs of pyometra after the implants. Deslorelin-treated ovaries appeared small, while control gonads were normal. It was concluded that long-term-release deslorelin, administered at approximately 50% adult body weight, postponed feline puberty without altering growing rate.

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats

“…This supports the previous studies in which tolerance of deslorelin implantation has been reported in prepubertal cats [7] and [19]. General health of the implanted and the control animals was also monitored by recording the weekly body weights of the cats throughout the study period.…”

Long-term contraception in a small implant

“…19 This was significantly later than the 15 queens of the control group, which displayed puberty when 177.8 ± 10.8 days old (mean ± SEM) (134–286 days). 19 Body weight at puberty was not different between the treated and the control groups. 19 However, one treated queen showed induced estrus and another showed clinical signs of pyometra 13 and 92 days, respectively, after treatment.…”

“…19 Fourteen of the 15 treated kittens reached puberty (diagnosed by estrous behavior and vaginal cytology) when 281.2 ± 21.6 days old (mean ± SEM) (range 180–428 days). 19 This was significantly later than the 15 queens of the control group, which displayed puberty when 177.8 ± 10.8 days old (mean ± SEM) (134–286 days). 19 Body weight at puberty was not different between the treated and the control groups.…”

“…Pivotal information used in this review has been obtained from scientific papers in peer-reviewed journals, 5,10–14,17–20 while supportive information has been sourced from meeting summaries and posters. 6,7,9,15,16,21 …”

Di̇şi̇ Köpek Ve Kedi̇lerde Üremeni̇n Kontrolünde GNRH Agoni̇stleri̇

“…Dişi kedilerde pubertas ergin ağırlığın % 75'ine ulaşıldığında meydana geldiğinden, ergin ağır-lığın % 50'sine ulaşıldığında implantların takılması önerilmektedir (15). Deslorelinin 4,7 mg dozdaki implantlarının kullanıldığı kedilerde kontrol grubuna ortalama 100 gün civarında pubertasın geciktiği bildirilmektedir (16). İmplantların kedilerin büyümesini etkilemediği ve flare-up etkisinin görülmedi-ği bildirilmektedir (16).…”