Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades

Lu, Xuefei; Zhu, Yong; Bai, Ru; Wu, Zhengsheng; Qian, Wangsheng; Yang, Leiyan; Cai, Rong; Yan, Hong; Li, Tao; Pandey, Vijay; Liu, Ying; Lobie, Peter E.; Chen, Chunying; Zhu, Tao

doi:10.1038/s41565-019-0472-4

Cited by 147 publications

(88 citation statements)

References 40 publications

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“…Future advancements in combination therapy between gas therapy and other treatment are expected to enhance the efficacy of gas therapy and simultaneously reduce the side effects of a single treatment. Last but not least, before these emerging delivery strategies can be used in clinical therapy, their physiological dispersibility and stability, biocompatibility, biodistribution as well as biosafety should be thoroughly evaluated by systematic studies . More worthy of mention, in order to achieve clinical translation of CO therapy, multidisciplinary collaboration would be essential.…”

Section: Resultsmentioning

confidence: 99%

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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Carbon monoxide (CO) therapy has emerged as a hot topic under exploration in the field of gas therapy as it shows the promise of treating various diseases. Due to the gaseous property and the high affinity for human hemoglobin, the main challenges of administrating medicinal CO are the lack of target selectivity as well as the toxic profile at relatively high concentrations. Although abundant CO releasing molecules (CORMs) with the capacity to deliver CO in biological systems have been developed, several disadvantages related to CORMs, including random diffusion, poor solubility, potential toxicity, and lack of on‐demand CO release in deep tissue, still confine their practical use. Recently, the advent of versatile nanomedicine has provided a promising chance for improving the properties of naked CORMs and simultaneously realizing the therapeutic applications of CO. This review presents a brief summarization of the emerging delivery strategies of CO based on nanomaterials for therapeutic application. First, an introduction covering the therapeutic roles of CO and several frequently used CORMs is provided. Then, recent advancements in the synthesis and application of versatile CO releasing nanomaterials are elaborated. Finally, the current challenges and future directions of these important delivery strategies are proposed.

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Section: Resultsmentioning

confidence: 99%

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Yan

Zhu

et al. 2019

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“…Moreover, CNTs are suspected to be cytotoxic, limiting their applications in bio-systems. [25][26][27] Various methods have been developed to address the above limitations. Surfactants are widely used to allow CNT dispersion in water.…”

Section: Doi: 101002/adma202000165mentioning

confidence: 99%

Stable and Biocompatible Carbon Nanotube Ink Mediated by Silk Protein for Printed Electronics

et al. 2020

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Ink‐based processes, which enable scalable fabrication of flexible devices based on nanomaterials, are one of the practical approaches for the production of wearable electronics. However, carbon nanotubes (CNTs), which possess great potential for flexible electronics, are facing challenges for use in inks due to their low dispersity in most solvents and suspicious cytotoxicity. Here, a stable and biocompatible CNT ink, which is stabilized by sustainable silk sericin and free from any artificial chemicals, is reported. The ink shows stability up to months, which can be attributed to the formation of sericin–CNT (SSCNT) hybrid through non‐covalent interactions. It is demonstrated that the SSCNT ink can be used for fabricating versatile circuits on textile, paper, and plastic films through various techniques. As proofs of concept, electrocardiogram electrodes, breath sensors, and electrochemical sensors for monitoring human health and activity are fabricated, demonstrating the great potential of the SSCNT ink for smart wearables.

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“…All the animal experimental protocols were approved and performed according guidelines and regulations of the Ethics Committee of the Biological Research Centre of the Hungarian Academy of Sciences and the Hungarian National Animal Experimentation and Ethics Board, in possession of an ethical clearance (number: XVI./1489/2014). 4T1-based tumour metastasis model has been applied as reported previously [39]. More precisely, for in vivo tumour growth, 100,000 4T1 cells were suspended in 100 µL RPMI and the cell suspensions were injected into the thoracic fat pad of 6-8 week old female Balb/c mice.…”

Section: Animal Studiesmentioning

confidence: 99%

Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts

et al. 2020

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Background: Although accumulating evidence suggests that the crosstalk between malignant cells and cancerassociated fibroblasts (CAFs) actively contributes to tumour growth and metastatic dissemination, therapeutic strategies targeting tumour stroma are still not common in the clinical practice. Metal-based nanomaterials have been shown to exert excellent cytotoxic and anti-cancerous activities, however, their effects on the reactive stroma have never been investigated in details. Thus, using feasible in vitro and in vivo systems to model tumour microenvironment, we tested whether the presence of gold, silver or gold-core silver-shell nanoparticles exerts anti-tumour and metastasis suppressing activities by influencing the tumour-supporting activity of stromal fibroblasts. Results: We found that the presence of gold-core silver-shell hybrid nanomaterials in the tumour microenvironment attenuated the tumour cell-promoting behaviour of CAFs, and this phenomenon led to a prominent attenuation of metastatic dissemination in vivo as well. Mechanistically, transcriptome analysis on tumour-promoting CAFs revealed that silver-based nanomaterials trigger expressional changes in genes related to cancer invasion and tumour metastasis. Conclusions: Here we report that metal nanoparticles can influence the cancer-promoting activity of tumour stroma by affecting the gene expressional and secretory profiles of stromal fibroblasts and thereby altering their intrinsic crosstalk with malignant cells. This potential of metal nanomaterials should be exploited in multimodal treatment approaches and translated into improved therapeutic outcomes.

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Long-term pulmonary exposure to multi-walled carbon nanotubes promotes breast cancer metastatic cascades

Cited by 147 publications

References 40 publications

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Emerging Delivery Strategies of Carbon Monoxide for Therapeutic Applications: from CO Gas to CO Releasing Nanomaterials

Stable and Biocompatible Carbon Nanotube Ink Mediated by Silk Protein for Printed Electronics

Core–shell nanoparticles suppress metastasis and modify the tumour-supportive activity of cancer-associated fibroblasts

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