Long-Term Prognostic Impact of Contrast-Enhanced Ultrasound and Power Doppler in Renal Transplantation

Mori, Giacomo; Granito, M.; Favali, Davide; Cappelli, Gianni

doi:10.1016/j.transproceed.2014.11.080

Cited by 17 publications

(13 citation statements)

References 6 publications

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“…While percutaneous needle biopsy remains the reference standard for diagnosis of acute allograft rejection, new noninvasive imaging techniques aimed at detecting early signs of rejection may allow greater specificity in selecting which patients should ultimately undergo biopsy. Microbubble contrast-enhanced US is a diagnostic tool with promising applications in the renal transplant patient population, combining the general advantages of standard US (eg, lack of ionizing radiation, cost-effectiveness, and wide availability) with the advantage of a contrast agent that does not require renal filtration (141).…”

Section: Future Directionsmentioning

confidence: 99%

Imaging of Renal Transplant Complications throughout the Life of the Allograft: Comprehensive Multimodality Review

et al. 2019

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The kidney is the most commonly transplanted solid organ. Advances in surgical techniques, immunosuppression regimens, surveillance imaging, and histopathologic diagnosis of rejection have allowed prolonged graft survival times. However, the demand for kidneys continues to outgrow the available supply, and there are efforts to increase use of donor kidneys with moderate-or highrisk profiles. This highlights the importance of evaluating the renal transplant patient in the context of both donor and recipient risk factors. Radiologists play an integral role within the multidisciplinary team in care of the transplant patient at every stage of the transplant process. In the immediate postoperative period, duplex US is the modality of choice for evaluating the renal allograft. It is useful for establishing a baseline examination for comparison at future surveillance imaging. In the setting of allograft dysfunction, advanced imaging techniques including MRI or contrastenhanced US may be useful for providing a more specific diagnosis and excluding nonrejection causes of renal dysfunction. When a pathologic diagnosis is deemed necessary to guide therapy, USguided biopsy is a relatively low-risk, safe procedure. The range of complications of renal transplantation can be organized temporally in relation to the time since surgery and/or according to disease categories, including immunologic (rejection), surgical or iatrogenic, vascular, urinary, infectious, and neoplastic complications. The unique heterotopic location of the renal allograft in the iliac fossa predisposes it to a specific set of complications. As imaging features of infection or malignancy may be nonspecific, awareness of the patient's risk profile and time since transplantation can be used to assign the probability of a certain diagnosis and thus guide more specific diagnostic workup. It is critical to understand variations in vascular anatomy, surgical technique, and independent donor and recipient risk factors to make an accurate diagnosis and initiate appropriate treatment. ©

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Section: Future Directionsmentioning

confidence: 99%

Imaging of Renal Transplant Complications throughout the Life of the Allograft: Comprehensive Multimodality Review

et al. 2019

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“…In addition, CEUS has several advantages over traditional imaging techniques, including cost-effectiveness, portability, lack of radiation, non-invasiveness, and better patient compliance [ 11 ], which may be why CEUS performs better than US in the diagnosis of renal cystic lesions [ 12 ]. CEUS plays an important role in the identification of malignant lesions in various organs, such as colon, gallbladder, pancreas, and kidney [ 13 – 15 ]. Although the improvement in diagnostic performance of conventional US combined with CEUS in the differentiation capability for benign from malignant breast masse has been elucidated in previous data [ 9 ], there is limited data on conventional US combined with CEUS in differentiating solitary thyroid nodule (STN) and micronodules from normal thyroid tissue.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Conventional Ultrasonography Combined with Contrast-Enhanced Ultrasonography in Thyroid Imaging Reporting and Data System (TI-RADS) 3 and 4 Thyroid Micronodules

Liu

Wu²,

Zhou³

et al. 2016

Med Sci Monit

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BackgroundThe present study was conducted to investigate the diagnostic performance of conventional ultrasonography (US) combined with contrast-enhanced ultrasonography (CEUS) in thyroid micronodules with thyroid imaging reporting and data system (TI-RADS) category 3 and 4.Material/MethodsThe features of conventional US and CEUS ion 102 case of thyroid micronodule samples, which were diagnosed based on pathological and clinical examination, were retrospectively analyzed. Logistic regression analysis was used to analyze the diagnostic accuracy in malignant thyroid micronodules. Receiver operator characteristic (ROC) curve was used to assess the performance of those 2 technologies.ResultsA significant difference in age was found between the benign and malignant groups. The benign and malignant groups showed significant differences in shape, margin, aspect ratio (A/T) ≥1, microcalcification, suspicious lymph gland, enhancement time, enhancement pattern, enhancement intensity, nodule sizes, enhancement margins, and rim-like enhancement. Logistic regression analysis of conventional US showed that A/T ≥1, irregular shape, microcalcification, and suspicious lymph glands are risk factors for thyroid micronodules, while logistic regression analysis of CEUS showed that slow enhancement time and absence of rim-like enhancement are risk factors for thyroid micronodules. Logistic regression analysis of conventional US combined with CEUS demonstrated that A/T ≥1, microcalcification, suspicious lymph gland, slow enhancement time, and absence with rim-like enhancement are risk factors. The ROC curve for conventional US, CEUS, and conventional US combined with CEUS were 90.0%, 90.7%, 99.0%, respectively.ConclusionsOur results show that conventional US combined with CEUS had superior diagnostic performance for TI-RADS 3 and 4 thyroid micronodules compared with conventional US and CEUS alone.

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“…CEUS has been extensively used in cardiology [20], oncology [21,22], hepatology [23][24][25][26], gastroenterology [27][28][29][30], and in the study of vascular diseases [29,30]. In nephrology, the indication of CEUS includes the detection and characterization of renal pseudotumors, complex cystic lesions, vascular disorders such as thrombosis, infarction, cortical necrosis, trauma [6,[31][32][33][34][35][36], and the evaluation of transplanted kidney [8,37,38]. In various experimental models, CEUS provided a detailed visualization of parenchymal microvessels and a measure of the flow and perfusion of the tissue [11,12].…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasonography in chronic glomerulonephritides: correlation with histological parameters of disease activity

et al. 2018

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Long-Term Prognostic Impact of Contrast-Enhanced Ultrasound and Power Doppler in Renal Transplantation

Cited by 17 publications

References 6 publications

Imaging of Renal Transplant Complications throughout the Life of the Allograft: Comprehensive Multimodality Review

Imaging of Renal Transplant Complications throughout the Life of the Allograft: Comprehensive Multimodality Review

Diagnostic Value of Conventional Ultrasonography Combined with Contrast-Enhanced Ultrasonography in Thyroid Imaging Reporting and Data System (TI-RADS) 3 and 4 Thyroid Micronodules

Contrast-enhanced ultrasonography in chronic glomerulonephritides: correlation with histological parameters of disease activity

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