Long-term prognosis of gastric cancer in a European country

Barchielli, A; Amorosi, Andrea; Balzi, Daniela; Crocetti, Emanuele; Nesi, Gabriella

doi:10.1016/s0959-8049(01)00179-4

Cited by 29 publications

(6 citation statements)

References 21 publications

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“…Of note, survival with GC varies depending upon the geographic area, with the highest survival rate observed in southern and central Europe and the lowest in Eastern Europe, United Kingdom, and Ireland [ 1 ]. Among the European countries, a high incidence of mortality from GC is encountered in Italy [ 2 , 5 , 6 ]; interestingly, a remarkable peculiar geographic variation was reported in this country [ 2 , 5 , 6 ] with the highest death rate in central and northern regions and the lowest in southern Italy [ 2 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach

et al. 2015

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Objectives. HER2 expression in gastric cancer (GC) has received attention as a potential target for therapy with Trastuzumab. We reviewed the current knowledge on HER2 status in premalignant gastric lesions and in early (EGC) and advanced (AGC) GC to discuss the possible pathogenetic and prognostic roles of HER2 overexpression in GC. Results. HER2 overexpression was documented in gastric low-grade (LG) and high-grade intraepithelial neoplasia (HG-IEN), with higher frequency in gastric type dysplasia. HER2 overexpression was significantly associated with disease recurrence and poor prognosis in EGC representing an independent risk factor for lymph node metastases. HER2 overexpression was more frequent in AGC characterized by high grade, advanced stage, and high Ki-67 labeling index. The discordance in HER2 status was evidenced between primitive GC and synchronous or metachronous metastases. Conclusions. HER2 overexpression in premalignant gastric lesions suggests its potential involvement in the early steps of gastric carcinogenesis. The assessment of HER2 status in EGC may be helpful for the identification of patients who are at low risk for developing nodal metastases. Finally, the possible discordance in HER2 status between primary GC and its synchronous metastases support routine assessment of HER2 both in the primary GC and in its metastatic lesions.

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Section: Introductionmentioning

confidence: 99%

HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach

et al. 2015

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“…The stages of disease have significant effect on patients' lifetime (P<0.001), such as many other studies (Msika et al, 2000;Barchielli et al, 2001;Thong-Ngam et al, 2001;Tian et al, 2004;Khedmat et al, 2007;Biglarian et al, 2009;Roshanaei et al, 2010) and this proved the necessity of disease diagnosis at early stages of disease.…”

Section: Discussionmentioning

confidence: 75%

Estimation of Hazard Function and its Associated Factors in Gastric Cancer Patients using Wavelet and Kernel Smoothing Methods

Ahmadi

Roudbari

Gohari³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background and Objectives: Increase of mortality rates of gastric cancer in Iran and the world in recent years reveal necessity of studies on this disease. Here, hazard function for gastric cancer patients was estimated using Wavelet and Kernel methods and some related factors were assessed. Materials and Methods: Ninetyfive gastric cancer patients in Fayazbakhsh Hospital between 1996 and 2003 were studied. The effects of age of patients, gender, stage of disease and treatment method on patient's lifetime were assessed. For data analyses, survival analyses using Wavelet method and Log-rank test in R software were used. Results: Nearly 25.3% of patients were female. Fourteen percent had surgery treatment and the rest had treatment without surgery. Three fourths died and the rest were censored. Almost 9.5% of patients were in early stages of the disease, 53.7% in locally advance stage and 36.8% in metastatic stage. Hazard function estimation with the wavelet method showed significant difference for stages of disease (P<0.001) and did not reveal any significant difference for age, gender and treatment method. Conclusion: Only stage of disease had effects on hazard and most patients were diagnosed in late stages of disease, which is possibly one of the most reasons for high hazard rate and low survival. Therefore, it seems to be necessary a public education about symptoms of disease by media and regular tests and screening for early diagnosis.

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“…The 5-year overall survival rate of synchronous liver metastases from gastric cancer was less than 27% [[1], [2], [3]]. Some scholars reported GCLM patients with long-term survival, but no one live for more than 7 years [[4], [5], [6], [7], [8]]. To the best of our knowledge, this is the first report of a patient with synchronous liver metastases from gastric cancer who experienced stable disease for more than 7 years following multidisciplinary treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis for patients with liver metastases from gastric cancer is very poor and the 5-year overall survival rate of synchronous liver metastases from gastric cancer was less than 27% [[1], [2], [3]]. Some scholars reported GCLM patients with long-term survival, but no one live for more than 7 years [[4], [5], [6], [7], [8]].…”

Section: Introductionmentioning

confidence: 99%

Long-term survival with stable disease after multidisciplinary treatment for synchronous liver metastases from gastric cancer: A case report

Shi

Wang

Zhang

et al. 2019

International Journal of Surgery Case Reports

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HighlightsBased on the patients with better performance status, partial gastrectomy combining metastasectomy of liver is potentially useful in contributing to decrease tumor loading and cytokines secretion of tumor, which may result in immunosuppression.PVC has the potential to be a well-tolerated and excellent option in GCLM patients who have no extrahepatic metastases.Patients who without extrahepatic metastases, sensitive and well-tolerate to chemotherapy, having better performance status may get good prognosis.

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Long-term prognosis of gastric cancer in a European country

Cited by 29 publications

References 21 publications

HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach

HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach

Estimation of Hazard Function and its Associated Factors in Gastric Cancer Patients using Wavelet and Kernel Smoothing Methods

Long-term survival with stable disease after multidisciplinary treatment for synchronous liver metastases from gastric cancer: A case report

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