Long-Term Persistence of Neutralizing Memory B&amp;nbsp;Cells in SARS-CoV-2

Abayasingam, Arunasingam; Balachandran, Harikrishnan; Agapiou, David; Rodrigo, Chaturaka; Keoshkerian, Elizabeth; Li, Hui; Brasher, Nicholas A.; Christ, Daniel; Rouet, Romain; Burnett, Deborah L.; Grubor‐Bauk, Branka; Rawlinson, William D.; Turville, Stuart; Aggarwal, Anupriya; Brilot, Fabienne; Mina, Michael; Post, Jeffrey J.; Hudson, Bernard; Gilroy, Nicky; Dwyer, Dominic E.; Sasson, Sarah C.; Tea, Fiona; Pilli, Deepti; Tedla, Nicodemus; Lloyd, Andrew R.; Martinello, Marianne; Bull, Rowena A.; Group, COSIN Study

doi:10.2139/ssrn.3732365

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“…To take into account the first phase of decay observed during early convalescence, we propose an optimal window for plasmapheresis, up to 100 days post-diagnosis. Furthermore, the occurrence of a small group of individuals, termed “high and elite responders” with highly neutralising, broad, and sustained SARS-CoV-2 antibody responses over time, may be due to the rapid and lasting generation of memory B cells ( 32 ). These patients were likely to be hospitalized older males.…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 neutralizing antibodies; longevity, breadth, and evasion by emerging viral variants

Tea

Stella

Aggarwal

et al. 2020

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The SARS-CoV-2 antibody neutralization response and its evasion by emerging viral variants are unknown. Antibody immunoreactivity against SARS-CoV-2 antigens and Spike variants, inhibition of Spike-driven virus-cell fusion, and infectious SARS-CoV-2 neutralization were characterized in 807 serial samples from 233 RT-PCR-confirmed COVID-19 individuals with detailed demographics and followed up to seven months. A broad and sustained polyantigenic immunoreactivity against SARS-CoV-2 Spike, Membrane, and Nucleocapsid proteins, along with high viral neutralization were associated with COVID-19 severity. A subgroup of ‘high responders’ maintained high neutralizing responses over time, representing ideal convalescent plasma therapy donors. Antibodies generated against SARS-CoV-2 during the first COVID-19 wave had reduced immunoreactivity and neutralization potency to emerging Spike variants. Accurate monitoring of SARS-CoV-2 antibody responses would be essential for selection of optimal plasma donors and vaccine monitoring and design.One Sentence SummaryNeutralizing antibody responses to SARS-CoV-2 are sustained, associated with COVID19 severity, and evaded by emerging viral variants

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Section: Discussionmentioning

confidence: 99%