Long-term pediatric hematological morbidity of the early-term newborn

Abstract

Children born at early term (37 0/7 to 38 6/7 weeks' gestation) are at an increased risk for long-term respiratory, cardiovascular, neurological, and developmental morbidities as compared with children born at full term (39 0/7 to 40 6/7 weeks' gestation). In this population-based cohort analysis, we sought to evaluate the long-term hematological morbidity of early-term born children. The cohort consisted of 223,242 term singleton deliveries. Hospitalizations of the offspring up to 18 years of age involving hematological morbidity were evaluated, including hereditary and acquired anemias, immunodeficiency disorders, coagulation disorders, white blood cell disorders, cytopenias, polycythemia, and myelodysplastic syndrome. Hematological hospitalizations were significantly more common in children delivered at early term as compared with those born at later gestational ages. A Kaplan-Meier survival curve demonstrated a significantly higher cumulative incidence of hematological-related hospitalizations in the early-term born group (logrank p < 0.001). Using a Cox regression model, early-term delivery was found to be an independent risk factor for childhood hematological morbidity with an adjusted hazard ratio of 1.15 (95%CI 1.01-1.30, p=0.027).Conclusion: Early-term delivery appears to be independently associated with pediatric long-term hematological morbidity of the offspring. What is Known? • It has been shown that children born at early term are at increased risk for short-term adverse outcomes including perinatal mortality. • Early-term infants are also at increased risk for long-term morbidity, mainly respiratory. What is New? • Early-term delivery is also independently associated with long-term hematological morbidity of the offspring.

The Association between Preterm Birth and Ambient Air Pollution Exposure in Shiyan, China, 2015–2017

“…As a minor adverse pregnancy outcome relative to PTB advocated by ACOG [ 19 ], the relationship between ambient air pollution exposure and ETB should be generalized and echoed from previous conclusions on PTB. The adverse effects of ETB on newborns have been discussed in published studies [ 23 ], but the association between ambient pollutants exposure and ETB has still been rarely studied. The findings of this study complement the research for influencing the factors for ETB, and suggest that future studies in this field should pay more attention to no medically assisted deliveries at less than 39 weeks of gestation, which will improve the understanding of the association between ambient air pollution exposure and adverse pregnancy outcomes.…”

Early‐term deliveries and long‐term pediatric ophthalmic morbidity of the offspring#

“…Early‐term deliveries were found to be associated with both short‐ and long‐term neonatal adverse outcomes. Long‐term adverse outcomes suggested to be associated with early‐term delivery include respiratory, cardiovascular, hematologic, and endocrine morbidities 10–13 . All were found to be more common among early‐term infants as compared with full‐term infants.…”

“…Long-term adverse outcomes suggested to be associated with early-term delivery include respiratory, cardiovascular, hematologic, and endocrine morbidities. [10][11][12][13] All were found to be more common among early-term infants as compared with full-term infants. Increased ocular morbidity in very premature infants has been extensively documented.…”