Maternal anemia and long-term respiratory morbidity of the offspring—Results of a population-based cohort

Alcalay, Idan; Wainstock, Tamar

doi:10.1007/s00404-022-06780-1

Cited by 3 publications

(2 citation statements)

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“…However, it is unclear why certain individuals are more susceptible to respiratory diseases during childhood than others with potential multifactorial causes. One possible explanation for respiratory morbidity in early childhood is linked to lung maldevelopment due to in‐utero or early childhood events 2–7 …”

Section: Introductionmentioning

confidence: 99%

“…One possible explanation for respiratory morbidity in early childhood is linked to lung maldevelopment due to in-utero or early childhood events. [2][3][4][5][6][7] Lung development begins as early as the third gestational week and is a complex process that is influenced by a combination of genetic and environmental factors. The developmental plasticity hypothesis suggests that chronic diseases later in life may result from adverse early life exposures that lead to early adaptation mechanisms.…”

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confidence: 99%

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The impact of maternal hyperemesis gravidarum on early childhood respiratory morbidity

Hazan,

Sheiner,

Golan‐Tripto

et al. 2023

Pediatric Pulmonology

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BackgroundLung maldevelopment due to in‐utero events may potentially cause respiratory morbidity during childhood. Maternal nutritional status during pregnancy is critical for lung development. This study is contributing to the understanding of the interplay between maternal nutrition status during pregnancy, fetal lung development and the risk for respiratory diseases in early life.Research QuestionTo investigate the association between maternal hyperemesis gravidarum (HG) during pregnancy and respiratory morbidity in the offspring's early childhood.Study Design and MethodsThis is a retrospective population‐based cohort study that included all singleton term deliveries at Soroka University Medical Center (SUMC) between 1991 and 2021. Preterm deliveries (<37 gestational week), perinatal deaths, multiple gestations, and children with congenital malformations or chromosomal abnormalities were excluded. The main outcomes measured were offspring's hospitalizations due to pneumonia, acute bronchiolitis, asthma, or wheezing.ResultsOverall 232,476 deliveries were included in the study, of which 3227 women (1.4%) were diagnosed with HG. Offspring in the HG group exhibited significantly higher rates of respiratory morbidity, including asthma (OR = 1.36, 95% CI 1.22–1.36, p < .001), acute bronchiolitis (OR = 1.38, 95% CI 1.21–1.59, p < .001), and pneumonia (OR = 1.2, 95% CI 1.12–1.48, p < .001). An inverse correlation between multivariate adjusted‐hazard ratios for asthma and pneumonia with offspring's age was noted.InterpretationThis study provides evidence of a potential association between maternal HG during pregnancy and increased risk of respiratory morbidity in offspring's early childhood. Maternal nutritional status during pregnancy plays a crucial role in lung development, affecting respiratory health in childhood.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%