Long-term patency of small-diameter vascular graft made from fibroin, a silk-based biodegradable material

Enomoto, Soichiro; Sumi, Makoto; Kajimoto, Kan; Nakazawa, Yasumoto; Takahashi, R.; Takabayashi, Chiyuki; Asakura, Tetsuo; Sata, Masataka

doi:10.1016/j.jvs.2009.09.005

Cited by 208 publications

(200 citation statements)

References 38 publications

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“…Wu et al demonstrated rapid remodeling using a graft made of poly(glycerol sebacate), a fast-degrading elastomer, in a rat arterial implantation model having good patency. Natural proteins such as silk fibroin 15 and chitosan 16 have also been used as biodegradable materials for small-diameter arterial grafts, and showed long-term patency with favorable vessel remodeling. These materials have clear potential for small artery grafts, but further investigation in large animals with longer Representative electronic microscope images of poly(glycolic acid) (PGA) mesh fiber coated with poly(l-lactide-co-ε-caprolactone) (PLCL) and electrospun poly(lactic acid) (PLA) nanofiber.…”

Section: Biodegradable Polymersmentioning

confidence: 99%

Vessel Bioengineering

Tara

Rocco

Hibino

et al. 2014

Circ J

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The development of vascular bioengineering has led to a variety of novel treatment strategies for patients with cardiovascular disease. Notably, combining biodegradable scaffolds with autologous cell seeding to create tissue-engineered vascular grafts (TEVG) allows for in situ formation of organized neovascular tissue and we have demonstrated the clinical viability of this technique in patients with congenital heart defects. The role of the scaffold is to provide a temporary 3-dimensional structure for cells, but applying TEVG strategy to the arterial system requires scaffolds that can also endure arterial pressure. Both biodegradable synthetic polymers and extracellular matrixbased natural materials can be used to generate arterial scaffolds that satisfy these requirements. Furthermore, the role of specific cell types in tissue remodeling is crucial and as a result many different cell sources, from matured somatic cells to stem cells, are now used in a variety of arterial TEVG techniques. However, despite great progress in the field over the past decade, clinical effectiveness of small-diameter arterial TEVG (<6 mm) has remained elusive. To achieve successful translation of this complex multidisciplinary technology to the clinic, active participation of biologists, engineers, and clinicians is required. (Circ J 2014; 78: 12 -19)

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Section: Biodegradable Polymersmentioning

confidence: 99%

Vessel Bioengineering

Tara

Rocco

Hibino

et al. 2014

Circ J

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“…Hemodynamics and antithrombotic indicators of the vascular prosthesis made of natural silk are better than vascular PTFE prosthesis [5].…”

Section: Implantsmentioning

confidence: 91%

Vascular Implants Reinforced with Natural Silk Yarns

Kancevicha

Lukyanchikovs

2014

Materials Science. Textile and Clothing Technology

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Abstract. In the course of this research work woven synthetic prosthesis reinforced with natural silk yarns was designed and manufactured. Biomechanical properties of surgical natural silk were studied during designing of the structure of the walls of the prosthesis. The experiment gave good data of elasticity and strain properties in a process of laboratory testing of samples of natural fibers. The previous practical experience was also used, for example, various vascular prostheses made from polyurethane complex yarns and polyester monofilaments. As a result, the authors of the scientific work proposed a combined wall structure of vascular prosthesis, consisting of polyester, polyurethane, and natural silk surgical yarns. After the implantation of the synthetic prosthesis reinforced with natural silk yarns, these natural silk yarns completely dissolve in the body for several years. Living tissue is gradually growing into the walls of synthetic prosthesis, replacing dissolved natural silk yarns. Experimental tests confirmed that a modulus of elasticity of innovative prosthesis is close to modulus of elasticity of natural blood vessels. The innovative structure of blood vessel prosthesis combined with such parameters can provide a long-term normal hemodynamics.

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“…5,6 We have already reported excellent results for the development of small-diameter vascular grafts made from SF. [7][8][9][10] These novel vascular grafts made from SF (length: 8 mm; internal diameter: 1.5 mm) improved the patency of the graft remarkably, that is, more than 85% patency remained after 1 year of implantation in rat abdominal aorta. 8,9 Although the SF fiber is superior in patency compared with other synthetic materials used in grafts, it is difficult to use the SF alone as an artificial vascular graft because of its poor mechanical stability, such as its low yielding property and weakness against bending.…”

Section: Introductionmentioning

confidence: 91%

“…[7][8][9][10] These novel vascular grafts made from SF (length: 8 mm; internal diameter: 1.5 mm) improved the patency of the graft remarkably, that is, more than 85% patency remained after 1 year of implantation in rat abdominal aorta. 8,9 Although the SF fiber is superior in patency compared with other synthetic materials used in grafts, it is difficult to use the SF alone as an artificial vascular graft because of its poor mechanical stability, such as its low yielding property and weakness against bending. In contrast, it is known that several types of polyurethanes (PUs) are satisfactory materials in solving thrombosis and operability problems because of their excellent elastic properties and their biocompatible, microporous structure.…”

Section: Introductionmentioning

confidence: 91%

Structural characterization of silk-polyurethane composite material for biomaterials using solid-state NMR

Nakazawa

Asano

Nakazawa

et al. 2012

Polym J

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In this paper, we performed solid-state nuclear magnetic resonance (NMR) measurements, including T 1 H and T 1q , of silk fibroin (SF)/polyurethane (PU) composites to examine their possible use as a material for artificial vascular grafts. In the development of new artificial vascular grafts made from SF/PU, it is important to examine the miscibility of the composites and their molecular dynamics, because these properties are intimately involved in the resulting physical properties of the resulting vascular graft. The T 1 H measurements showed that the domain size of the SF/PU ¼ 1:1 composite is smaller than the domain size of the 1:10 and 1:2 composites, indicating that the molecular miscibility between SF and PU are partially in close proximity, particularly in the SF/PU ¼ 1:1 composite. Additionally, we observed that the molecular motion of the soft segment of PU in the SF/PU composites becomes slow, suggesting that the soft segment of PU interacts with SF to some extent. These analyses provided basic structural information for the development of silk-based artificial vascular grafts using PU.

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Long-term patency of small-diameter vascular graft made from fibroin, a silk-based biodegradable material

Abstract: Small-diameter fibroin-based vascular grafts have excellent long-term patency. Bone marrow-derived cells contribute to vascular remodeling after graft implantation. Fibroin might be a promising material to engineer vascular prostheses for small arteries.

Cited by 208 publications

References 38 publications

Vessel Bioengineering

Vessel Bioengineering

Vascular Implants Reinforced with Natural Silk Yarns

Structural characterization of silk-polyurethane composite material for biomaterials using solid-state NMR

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