Long term outer retinal changes in central serous chorioretinopathy submitted to half-dose photodynamic therapy

Torres-Costa, Sónia; Penas, Susana; Cerqueira, Ana Rita; Brandão, Elisete; Carneiro, Ângela; Rocha‐Sousa, Amândio; Falcão‐Reis, Fernando

doi:10.1016/j.pdpdt.2021.102235

Cited by 4 publications

(3 citation statements)

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“…Most of the studies on retinal morphology alterations in the course of CSCR have concentrated on compromised ONL and POS layers [11][12][13][14][15][16][17][18][19][20][24][25][26][27][28]. ONL and POS thinning is consequently reported in chronic cases of CSCR and usually correlated with BCVA deficit [11][12][13][14][15][16][17][18]20]. Interestingly, Ooto et al [19] reported ONL thinning but not POS thinning in 36 eyes with CSC versus healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…Spectral domain optical coherence tomography (SD-OCT) testing has made it possible to evaluate individual retinal layers in the course of different retinal disorders, including CSCR [9,10]. Because this chorioretinopathy typically presents with subretinal fluid (SRF) and detachment of photoreceptors from the retinal pigment epithelium (RPE), most of the available CSCR studies concentrate on changes to the photoreceptor outer segments layer (POS) and outer nuclear layer (ONL) comprised of photoreceptor nuclei [11][12][13][14][15][16][17][18][19][20]. Literature evaluating the impact of CSCR on more inner retinal layers, including the ganglion cell complex layer (GC), is scarce [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Ganglion Cell Loss in the Course of Central Serous Chorioretinopathy

Gawęcki¹,

Grzybowski

2022

Ophthalmol Ther

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Introduction: Central serous chorioretinopathy (CSCR) as a clinical entity is potentially damaging and may significantly affect retinal morphology and function, especially in the chronic form. Our study aimed to determine the amount of deficit of best corrected visual acuity (BCVA) and individual retinal layers, including ganglion cells, in different types of CSCR and with reference to its duration. Methods: The retrospective analysis included 69 eyes of patients with resolved CSCR managed in Dobry Wzrok Ophthalmological Clinic between 1 January 2019 and 30 June 2022. The diagnosis of CSCR was based on the criteria outlined by the Central Serous Chorioretinopathy International Group. The analysis included data obtained from medical history, BCVA testing, and spectral domain optical coherence tomography (SD-OCT) measurements, with specific thickness values for individual retinal layers. The results were compared among affected eyes, unaffected fellow eyes, and healthy controls.Results: BCVA values were significantly lower in acute (0.08 ± 0.12 logMAR) and chronic (0.26 ± 0.19 logMAR) cases versus controls (0.0 logMAR). The thickness of all retinal layers (central subfoveal thickness, CST; inner retina with ganglion cell complex, GC; outer retina, ORT; and photoreceptor outer segments, POS) and macular volume (MV) were significantly decreased in chronic eyes versus controls (p \ 0.01). Acute eyes had significant thinning of the outer retina and POS only compared to control eyes (p \ 0.01). The amount of deficit in CST, ORT, GC, and MV was strongly correlated with poorer BCVA (p \ 0.001), and the deficit of CST, ORT, and GC was correlated with disease duration (p \ 0.05). The subfoveal choroidal thickness was significantly greater in affected and fellow eyes versus controls (p \ 0.001). Conclusion: Damage to the outer retina and photoreceptors occurs early in the course of CSCR, with a deficit in ganglion cells noted adjunctively in chronic forms of the disease. Further studies are required to precisely determine correlation between visual loss in CSCR and deficits in individual retinal layers.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ganglion Cell Loss in the Course of Central Serous Chorioretinopathy

Gawęcki¹,

Grzybowski

2022

Ophthalmol Ther

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“…12,13 The ONL thickness recovery as the SRF resorption is considered to be related to the photoreceptor salvage, supported by numerous ndings that the ONL thickness was correlated to BCVA. [5][6][7]19,20 Our research group has also recently reported ONL thickness recovery and its correlation with visual acuity improvement in the context of neovascular age-related macular degeneration treatment. 21 It is considered that the damaged photoreceptors without complete degeneration can be salvaged following the resolution of the SRF, resulting in ONL thickness recovery and improved visual acuity.…”

Section: Discussionmentioning

confidence: 99%

Changes in the outer nuclear layer and choroidal vascularity during the manifest and quiescent phases of acute central serous chorioretinopathy

Lim,

Kim,

Kim

et al. 2024

Preprint

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To investigate alteration of outer nuclear layer (ONL) and choroidal vascularity index (CVI) in different status of central serous chorioretinopathy (CSC). A retrospective review of 65 CSC eyes with subretinal fluid (manifest CSC) and 40 control eyes was conducted in a single tertiary university hospital. Differences in best-corrected visual acuity (BCVA), ONL, and CVI were compared. CVI was assessed both in the entire choroid (CVI-EC) and around the 1,500μm leakage area (CVI-1500). Measurements were repeated after the subretinal fluid resorption (quiescent CSC), and compared. CSC eyes showed worse BCVA, thinner ONL and greater CVI than controls. Quiescent CSC showed a recovery of ONL compared to the manifest CSC, along with the BCVA improvement. The resolution of the CSC revealed a decrease across all three choroidal areas (total, stromal and luminal), with a more pronounced reduction in the stromal than in the luminal choroidal area, leading to an increase in the CVI. This phenomenon was shown in both CVI-EC and CVI-1500. Conclusively, ONL thickness can be used as a quantitative biomarker for photoreceptor function in CSC. Increased CVI may reflect a disease activity. The stromal choroidal area is particularly sensitive in illustrating leakage from the choroidal vasculature.

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