Long-term Outcomes of Repeat vs Initial Trabeculectomy in Open-Angle Glaucoma

Law, Simon K.; Shih, Karen M.; Tran, Diana; Coleman, Anne L.; Caprioli, Joseph

doi:10.1016/j.ajo.2009.05.032

Cited by 129 publications

(129 citation statements)

References 14 publications

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“…Repeat surgery is less successful at achieving IOP reduction in open-angle glaucoma than is initial surgery at 3 years or more [26]. This is consistent with the results of this study in the case of uveitic glaucoma, where also a resurgery was associated with a higher risk of failure.…”

Section: Discussionsupporting

confidence: 82%

Surgical outcomes of uveitic glaucoma

Carreño¹,

Portero²,

Villarón³

et al. 2010

Acta Ophthalmologica

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Purpose Secondary glaucoma is a difficult and frequent complication of uveitis. The aim of this study is to describe the results of surgery in uveitic glaucoma and to identify situations linked to a high risk of failure of the surgery. Methods Retrospective observational study. Clinical and surgical data from 27 cases of uveitic glaucoma that underwent glaucoma surgery over a period of 9 years were collected. Results The main diagnosis and aetiology were anterior uveitis (61.90%) and herpes (38.10%) respectively. Trabeculectomy with mitomycin C was performed in 51.9% of the cases. An intraocular pressure lower than 16 mmHg and managed with less than two drugs was achieved in 48.15% of the cases. Higher risks of surgical failure were associated with intermediate uveitis, idiopathic uveitis, Fuchs' cyclitis, combined surgery with phacoemulsification, omission of mitomycin C, intraocular inflammation at surgery and relapse of the uveitis. Conclusions There are some situations linked to a high risk of failure of surgery in uveitic glaucoma, which should be avoided when possible, mainly the association of higher risk with combined approaches.

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Section: Discussionsupporting

confidence: 82%

Surgical outcomes of uveitic glaucoma

Carreño¹,

Portero²,

Villarón³

et al. 2010

Acta Ophthalmologica

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“…Moreover, an eye undergoing repeat trabeculectomy will still possess the same surgical risk factors that prevented the success of the initial surgery. Thus, both trabeculectomy in aphakic eyes and repeat trabeculectomy in any type of eyes are reported to have lower success rates than trabeculectomy in virgin eyes [10,11]. However, our study found that neither aphakia nor previous glaucoma surgery were a significant prognostic factor.…”

Section: Discussioncontrasting

confidence: 74%

Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy

et al. 2012

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“…Some investigators say that increasing age is the risk factor for surgical failure of initial trabeculectomy [10,11]. On the other hand, Law et al [6] report that a younger age is a risk factor for surgical failure of repeat trabeculectomy with MMC because older patients may have fewer activated fibroblasts and inflammatory cells than younger patients. Younger age was also found to be associated with higher IOP during 9 years of follow up in the Collaborative Initial Glaucoma Treatment Study [12].…”

Section: Discussionmentioning

confidence: 98%

“…Law et al, however, report that eyes of patients with open-angle glaucoma who underwent repeat trabeculectomy with MMC had lower success rates compared with those having had initial trabeculectomy with MMC [5]. Also, reports indicate that a younger age and a need for laser suture lysis were risk factors for surgical failure of repeat trabeculectomy [6]. To our best knowledge, however, no large-scale studies have analyzed the risk factors for trabeculectomy in patients with various types of glaucoma and a history of glaucoma surgery, including trabeculectomy and trabeculotomy.…”

Section: Introductionmentioning

confidence: 90%