Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy

Inoue, Toshihiro; Inatani, Masaru; Takihara, Yuji; Awai-Kasaoka, Nanako; Ogata-Iwao, Minako; Tanihara, Hidenobu

doi:10.1007/s10384-012-0171-2

Cited by 31 publications

(25 citation statements)

References 11 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We thus find it highly advisable to avoid disrupting conjunctival vessels when creating a 25-gauge sclerotomy in glaucomatous eyes that have undergone TLE. The prognostic factors for surgical failure of TLE with MMC in vitrectomized eyes have been reported to be high preoperative IOP and NVG [34]. As stated above, we had 3 NVG patients undergo additional TLE following 25GMIVS, and we were able to achieve a final reduction in IOP in all 3 eyes.…”

Section: Discussionmentioning

confidence: 86%

25-Gauge Microincision Vitrectomy to Treat Vitreoretinal Disease in Glaucomatous Eyes after Trabeculectomy

Kunikata

Aizawa

Fuse

et al. 2014

Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose. To determine the feasibility of using 25-gauge microincision vitrectomy surgery (25GMIVS) to treat vitreoretinal disease in glaucomatous eyes which have previously undergone trabeculectomy (TLE). Methods. A consecutive, interventional case series. We performed 25GMIVS in 15 glaucomatous eyes that had undergone TLE. Follow-up period was 11.5 months. Results. 25GMIVS was successfully used and led to improvement in visual acuity (P < 0.01). We performed 25GMIVS for proliferative diabetic retinopathy with neovascular glaucoma in 53% of eyes (8 of 15). Although 3 eyes needed further TLE following 25GMIVS, final IOP was below 21 mmHg in all eyes except one eye (93%) and was comparable to pre-25GMIVS IOP (P = 0.20) without an increase in the number of glaucoma medications (P = 0.14). Conclusions. 25GMIVS is a feasible treatment for vitreoretinal disease in eyes with preexisting TLE, effective in both significantly improving BCVA and preserving the filtering bleb, while not excluding further glaucoma surgery.

show abstract

Section: Discussionmentioning

confidence: 86%

25-Gauge Microincision Vitrectomy to Treat Vitreoretinal Disease in Glaucomatous Eyes after Trabeculectomy

Kunikata

Aizawa

Fuse

et al. 2014

Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Another study demonstrated that NVG eyes with a history of vitrectomy had poor surgical outcomes after trabeculectomy [22]. Vitrectomy exacerbates retinal ischemia and increases the concentration of inflammatory cytokines and/or VEGF in the anterior chamber [3].…”

Section: Discussionmentioning

confidence: 99%

Hyphema is a risk factor for failure of trabeculectomy in neovascular glaucoma: a retrospective analysis

et al. 2014

View full text Add to dashboard Cite

BackgroundSeveral retinal ischemic diseases can cause neovascular glaucoma (NVG). Trabeculectomy with mitomycin C (MMC) is a relatively better treatment modality in the management of eyes with NVG than other glaucoma surgeries. The aim of this study was to investigate the factors that may influence the outcome of trabeculectomy with MMC for NVG.MethodsForty-nine NVG eyes from 43 patients (26 males and 17 females) underwent primary trabeculectomy with MMC. The mean follow-up period was 16.8 ± 8.1 months (range, 6 to 34 months). Twenty-one eyes of 21 patients received intravitreal bevacizumab (IVB) 3.6 ± 1.8 days before trabeculectomy with MMC. A Kaplan-Meier survival-curve analysis was used to summarize the cumulative probability of success. We examined the relationship between the surgical outcome and the following surgical factors: gender, age, history of panretinal photocoagulation, history of cataract surgery, history of vitrectomy, preoperative IVB, NVG in the fellow eye, and postoperative complications (hyphema, choroidal detachment, and formation of fibrin) by multivariate analysis.ResultsThe survival rate was 83.7% after 6 months, 70.9% after 12 months, and 60.8% after 24 months. The Kaplan-Meier survival curves showed no significant difference in the survival rate between the eyes with preoperative IVB (n = 21) and the eyes without preoperative IVB (n = 28) (p = 0.14). The multiple logistic regression analysis showed that postoperative hyphema (odds ratio, 6.54; 95% confidence interval, 1.41 to 35.97) was significantly associated with the surgical outcome (p = 0.02).ConclusionsPostoperative hyphema was significantly correlated with the outcome of trabeculectomy for NVG. There was no significant association between preoperative IVB and postoperative hyphema or the results of trabeculectomy.

show abstract

“…Inoue et al reported the success rate of trabeculectomy with adjunctive Mitomycin-C to be 55.1% at 1 year, decreasing to 43.1% at 3 years. They proposed that high preoperative IOP and neovascular glaucoma are risk factors for failure [91]. Glaucoma drainage implant can be considered when there is a high risk of failure with trabeculectomy or in previously failed trabeculectomy.…”

Section: Glaucoma After Retinal Surgerymentioning

confidence: 99%

Retina and glaucoma: surgical complications

et al. 2018

View full text Add to dashboard Cite

BackgroundThe close structural and microcirculatory co-relation between anterior and posterior segments of eye make them very vulnerable to complications when one of them is affected surgically. With the advent of anti-fibrotic agents in the management of glaucoma, the rates of vitreoretinal complications have become more frequent. Main bodyCommon retinal complications after glaucoma surgeries include choroidal detachment; ocular decompression retinopathy; haemorrhagic choroidal detachment; hypotony maculopathy; malignant glaucoma; vitreous haemorrhage; bleb endophthalmitis; retinal detachment. Similarly, intraocular pressure rise is often noted after scleral buckle; pars plana vitrectomy; intravitreal gas injection; silicone oil injection; intravitreal steroid injection.ConclusionThe article provides some insight into some of the complications after glaucoma and retina surgeries, including the pathogenetic mechanisms behind each complication and available management options.

show abstract

Prognostic risk factors for failure of trabeculectomy with mitomycin C after vitrectomy

Abstract: The prognostic factors for surgical failure of trabeculectomy with MMC in vitrectomized eyes are a higher preoperative IOP and NVG.

Cited by 31 publications

References 11 publications

25-Gauge Microincision Vitrectomy to Treat Vitreoretinal Disease in Glaucomatous Eyes after Trabeculectomy

25-Gauge Microincision Vitrectomy to Treat Vitreoretinal Disease in Glaucomatous Eyes after Trabeculectomy

Hyphema is a risk factor for failure of trabeculectomy in neovascular glaucoma: a retrospective analysis

Retina and glaucoma: surgical complications

Contact Info

Product

Resources

About