Long‐term outcomes of high dose carbon‐ion radiation therapy for unresectable upper cervical (<scp>C1</scp>‐2) chordoma

Aoki, Shuri; Koto, Masashi; Ikawa, Hiroaki; Imai, Reiko; Omatsu, Takashige; Shinoto, Makoto; Takiyama, Hirotoshi; Yamada, Shigeru; Tsuji, Hiroshi

doi:10.1002/hed.27127

Cited by 3 publications

(2 citation statements)

References 56 publications

(158 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Assessment on the toxicity of C-ion RT is presented in Table 4 [ 15 – 25 ]. Our systematic review observed grade 3 and 4 acute toxicity, with incidences of 2.9–5.3% and 0.5%, respectively [ 16 , 18 , 19 , 21 ]. For grade 4 and 5 late toxicities, the incidences were 2.1–5.9% and 2.9%, respectively [ 16 – 19 ].…”

Section: Resultsmentioning

confidence: 99%

“…The following factors were evaluated in nine studies: age, sex, Karnofsky performance status, gross target volume, planning target volume, tumour volume, level of proximal invasion, total irradiated dose, tumour status, eye symptoms, prior treatment, tumour-gastrointestinal distance, chemotherapy, spinal cord infiltration, and histology. Table 4 (Boldface indicates statistically significant difference) shows the main details of the prognostic factors of C-ion RT effectiveness in all the included studies [ 15 , 17 – 21 , 23 – 25 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy and safety of carbon ion radiotherapy for chordomas: a systematic review and meta-analysis

Dong,

Liu,

Zhang

et al. 2023

Radiat Oncol

View full text Add to dashboard Cite

Objective Carbon ion radiotherapy (C-ion RT) for chordomas has been gradually performed in several research centres. This study aimed to systematically review the results of clinical reports from these institutions and to evaluate the safety and efficacy of C-ion RT. Methods In accordance with the PRISMA guidelines and set search strategies, we searched four databases for articles from their inception to February 11, 2023. These articles were screened, and data were extracted independently by two researchers. STATA 14.0 was used for statistical analysis of survival results. Results A total of 942 related articles were retrieved, 11 of which were included. Regarding lesion location, 57% (n = 552) originated in the sacral region, 41% (n = 398) in the skull base, and 2% (n = 19) in the spine (upper cervical). The local control (LC) rates at 1, 2, 3, 5, 9, and 10 years in these studies were 96%, 93%, 83%, 76%, 71%, and 54%, respectively. The overall survival (OS) rates at 1, 2, 3, 5, 9, and 10 years in these studies were 99%, 100%, 93%, 85%, 76%, and 69%, respectively. Acute and late toxicities were acceptable, acute toxicities were mainly grade 1 to grade 2 and late toxicities were mainly grade 1 to grade 3. Conclusion C-ion RT has attractive clinical application prospects and is an important local treatment strategy for chordomas. Encouraging results were observed in terms of LC and OS. Meanwhile, the acute and late toxicities were acceptable. PROSPERO registration number: CRD42023398792.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Efficacy and safety of carbon ion radiotherapy for chordomas: a systematic review and meta-analysis

Dong,

Liu,

Zhang

et al. 2023

Radiat Oncol

View full text Add to dashboard Cite

show abstract

Long‐term outcomes of high dose carbon‐ion radiation therapy for unresectable upper cervical (C1‐2) chordoma

et al. 2022

View full text Add to dashboard Cite

Background: Chordoma is a rare, locally invasive neoplasm of the axial skeleton. Complete resection is often difficult, especially for the upper-cervical (C1-2) spine. We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) for unresectable C1-2 chordoma.Methods: Patients with C1-2 chordoma treated with definitive CIRT (60.8 Gy [RBE] in 16 fractions) were retrospectively analyzed. We evaluated OS, LC, PFS, and toxicity.Results: Nineteen eligible patients all completed the planned course of CIRT. With the median follow-up 68 months (range: 29-144), median OS was 126 months (range: 36-NA). Five-year OS, LC, and PFS were 68.4% (95% CI, 42.8%-84.4%), 75.2% (46.1%-90.0%), and 64.1% (36.3%-82.3%), respectively. Regarding acute toxicity of grade ≥3, there was only one grade 3 mucositis.Late toxicity included radiation-induced myelitis (grade 3 in 1 patient; 5.3%), and compression fractures (n = 5; 26.3%).Conclusions: High-dose CIRT is a promising treatment option for unresectable upper cervical chordoma.

show abstract

Effects of Photon versus Carbon-Ion Irradiation in the Rat Cervical Spinal Cord – a Serial T2 and Diffusion-weighted Magnetic Resonance Imaging Study

Welzel,

Saager,

Peschke

et al. 2024

Radiation Research

View full text Add to dashboard Cite

Carbon-ion irradiation is increasingly used at the skull base and spine near the radiation-sensitive spinal cord. To better characterize the in vivo radiation response of the cervical spinal cord, radiogenic changes in the high-dose area were measured in rats using magnetic resonance imaging (MRI) diffusion measurements in comparison to conventional photon irradiations. In this longitudinal MRI study, we examined the gray matter (GM) of the cervical spinal cord in 16 female Sprague-Dawley rats after high-dose photon (n = 8) or carbon-ion (12C) irradiation (n = 8) and in 6 sham-exposed rats until myelopathy occurred. The differences in the diffusion pattern of the GM of the cervical spinal cord were examined until the endpoint of the study, occurrence of paresis grade II of both forelimbs was reached. In both radiation techniques, the same order of the occurrence of MR-morphological pathologies was observed – from edema formation to a blood spinal cord barrier (BSCB) disruption to paresis grade II of both forelimbs. However, carbon-ion irradiation showed a significant increase of the mean apparent diffusion coefficient (ADC; P = 0.031) with development of a BSCB disruption in the GM. Animals with paresis grade II as a late radiation response had a highly significant increase in mean ADC (P = 0.0001) after carbon-ion irradiation. At this time, a tendency was observed for higher mean ADC values in the GM after 12C irradiation as compared to photon irradiation (P = 0.059). These findings demonstrated that carbon-ion irradiation leads to greater structural damage to the GM of the rat cervical spinal cord than photon irradiation due to its higher linear energy transfer (LET) value.

show abstract

Long‐term outcomes of high dose carbon‐ion radiation therapy for unresectable upper cervical (C1‐2) chordoma

Cited by 3 publications

References 56 publications

Efficacy and safety of carbon ion radiotherapy for chordomas: a systematic review and meta-analysis

Efficacy and safety of carbon ion radiotherapy for chordomas: a systematic review and meta-analysis

Long‐term outcomes of high dose carbon‐ion radiation therapy for unresectable upper cervical (C1‐2) chordoma

Effects of Photon versus Carbon-Ion Irradiation in the Rat Cervical Spinal Cord – a Serial T2 and Diffusion-weighted Magnetic Resonance Imaging Study

Contact Info

Product

Resources

About