Long-term outcomes of childhood meningitis

Fellick, J M; Thomson, A. P. J.

doi:10.12968/hosp.2002.63.5.2019

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…Unlike viral meningitis, bacterial meningitis may have a rapid onset, leading to death and serious neurological sequelae (20). Although highly effective antibiotics efficiently kill bacteria, mortality rates remain as high as 34z (21), and as many as 25z of the survivors suffer from long-term sequelae (22).…”

Section: Discussionmentioning

confidence: 99%

Acute Bacterial Meningitis among Children Admitted into an Iranian Referral Children's Hospital

et al. 2013

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SUMMARY: Bacterial meningitis is a serious threat to global health, particularly in developing countries. The aim of this study was to determine the etiological agents of acute bacterial meningitis, its clinical features, and antibacterial susceptibility among Iranian children who were admitted to a referral regional children's hospital. Laboratory data as well as symptoms and signs on admission, organism identification and antibiotic susceptibility results, physical examination findings, and neurologic features of 31 patients with suspected invasive bacterial infection were evaluated, of which 20 (64.5z) had positive cerebrospinal fluid (CSF) cultures. The microorganisms most commonly associated with bacterial meningitis in children were Streptococcus pneumoniae (7 isolates, 22.5z), Haemophilus influenzae (3 isolates, 10z), and Neisseria meningitidis (3 isolates, 10z). In our study, the rate of mortality and sequelae were 10z and 35z, respectively. Ventriculomegaly hydrocephalus was found in 1 case positive for Mycobacterium tuberculosis meningitis, while other signs of meningitis were negative. According to our results, abnormalities including brain edema, subdural effusion, microabscess, and ventriculomegaly hydrocephalus were observed in 50z of the patients with confirmed bacterial meningitis; therefore, identification of predictors of early neurological complications is highly recommended. In addition, CSF culture using the BACTEC automated system is recommended for detection of the etiologic agents of bacterial meningitis, particularly in a population like ours, in which the patients receive a course of antibiotics without prescription.

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Section: Discussionmentioning

confidence: 99%

Acute Bacterial Meningitis among Children Admitted into an Iranian Referral Children's Hospital

et al. 2013

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“…Acute meningitis may be caused by bacteria or virus; whereas, sub-acute or chronic meningitis are usually caused by mycobacterium tuberculosis, fungi or parasites. Viral meningitis is rarely severe and children tend to have a complete recovery, whereas bacterial meningitis can have a rapid onset, leading to death and serious neurological sequele 1 . The global burden of the disease is high.…”

Section: Introductionmentioning

confidence: 99%

Meningitis in Children: A Study in Medical College & Hospital, Kolkata

Joardar

Mandal³

et al. 2012

Bangladesh J Child Health

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“…Two thirds of meningitis deaths in low-income countries occur among children under 15 years of age [4]. Acute meningitis may be caused by bacteria or virus where children with viral meningitis experience of disease severity and ramifications less often compared to bacterial meningitis which usually has a rapid onset, with a progression towards serious neurological sequele and death [5]. Longstanding sequele including sensory deficit like deafness or blindness, and impairment of physical and cognitive development are common in developing coun- tries which is mostly due to delay in diagnosis [6].…”

Section: Introductionmentioning

confidence: 99%

Predictors of Meningitis in Under-Fifteen Children Attending an Intensive Care Unit of an Urban Large Diarrheal Disease Hospital in Bangladesh

Afroze¹,

Ahmed²,

Sarker³

et al. 2014

FNS

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Background: Data are lack on predicting features of meningitis in diarrheal children although the great clinical importance. Objective: To evaluate clinical and laboratory features in predicting meningitis in under-fifteen children having diarrheal illnesses. Methods: Children aged 1 month to 15 years, admitted in the ICU of the Dhaka Hospital of icddr, b between March 2011 and February 2012 with fever and seizure or altered consciousness and having LP done were enrolled into this analysis. Those children who had abnormal CSF findings [pleocytosis (normal range of leukocyte, 0-10/mm 3) and/or elevated protein (normal range, 0.10-0.45 mg/dl) and low glucose (normal value, 60% of corresponding blood glucose)] were defined as meningitis. Comparison was made between children with (cases = 17) and without meningitis (controls = 66) from our study children. Data were retrospectively collected from SHEBA, an online database system of the Dhaka Hospital of icddr, b. Results: Death was significantly higher among the cases compared to the controls (29% vs. 3%, p = 0.003). In logistic regression analysis, after adjusting for potential confounders, cases frequently had hypoxemia (95% CI 1.55-21.93), absent peripheral pulse (95% CI 1.95-27.13) and neutrophilia (95% CI 1.13-17.00). Conclusion: Our data suggest that children with meningitis had higher case fatality rate. Simple independent predictors of meningitis such as hypoxemia, absent peripheral pulse, and neutrophilia may help clinicians to initiate early and prompt management in order to curve lifelong sequel due to meningitis and death in such patient population especially those in resource poor settings.

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Long-term outcomes of childhood meningitis

Abstract: Meningitis and meningococcal disease remain a major source of anxiety to paediatricians and parents alike. Survival rates have improved with rapid diagnosis and appropriate management. However, survivors remain at risk of long-term neurodevelopmental sequelae.

Cited by 7 publications

References 13 publications

Acute Bacterial Meningitis among Children Admitted into an Iranian Referral Children's Hospital

Acute Bacterial Meningitis among Children Admitted into an Iranian Referral Children's Hospital

Meningitis in Children: A Study in Medical College & Hospital, Kolkata

Predictors of Meningitis in Under-Fifteen Children Attending an Intensive Care Unit of an Urban Large Diarrheal Disease Hospital in Bangladesh

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