Long-term outcomes in idiopathic nephrotic syndrome: from childhood to adulthood

Skrzypczyk, Piotr; Pańczyk-Tomaszewska, Małgorzata; Roszkowska‐Blaim, Maria; Wawer, Zofia; Bieniaś, Beata; Zajgzkowska, Malgorzata; Kiliś‐Pstrusińska, Katarzyna; Jakubowska, Anna; Szczepaniak, Marta; Pawlak-Bratkowska, Monika; Tkaczyk, Marcin

doi:10.5414/cn108044

Cited by 54 publications

(44 citation statements)

References 18 publications

(28 reference statements)

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“…Skrzypczyk et al compared their figures (23% overweight and 5% obese) with data for the general Polish population and found similar proportions, as overweight and obesity affected 24% aged 18‐39 years. Thus, they suggested that NS in childhood did not increase the risk of overweight and obesity during the long‐term follow‐up period . We also reviewed two German studies .…”

Section: Obesity and Overweightmentioning

confidence: 95%

“…In the long‐term cohorts, 19%‐35% of patients were overweight, with a body mass index (BMI) of ≥25 to 30 kg/m 2 and 2%‐17% were obese (BMI ≥ 30 kg/m 2 or >97 percentile) . Skrzypczyk et al compared their figures (23% overweight and 5% obese) with data for the general Polish population and found similar proportions, as overweight and obesity affected 24% aged 18‐39 years. Thus, they suggested that NS in childhood did not increase the risk of overweight and obesity during the long‐term follow‐up period .…”

Section: Obesity and Overweightmentioning

confidence: 99%

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Review on long‐term non‐renal complications of childhood nephrotic syndrome

et al. 2019

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Background Nephrotic syndrome (NS) is the most common glomerular childhood disease. A body of literature has described the long‐term renal prognosis of childhood‐onset idiopathic NS. However, the nonrenal outcomes have not been studied as much. Aim We aimed to discuss the long‐term non‐renal outcomes of childhood NS, highlighting studies with a follow‐up period of more than 10 years. Results We reviewed the literature and found that a number of immunosuppressive agents have stopped inflammation, stabilised the podocyte cytoskeleton and reduce proteinuria. However, prolonged treatment has frequently been associated with a high risk of renal and non‐renal complications in patients with a complicated disease course, defined as frequent relapses or steroid dependency. Non‐renal complications may include impaired longitudinal growth and pubertal development, undesirable fertility outcomes, ocular complications, bone mineral diseases and potential malignancies. Conclusion This review discusses and summarises the non‐renal outcomes of idiopathic childhood NS.

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Section: Obesity and Overweightmentioning

confidence: 95%

Section: Obesity and Overweightmentioning

confidence: 99%

Review on long‐term non‐renal complications of childhood nephrotic syndrome

et al. 2019

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“…Важным остается вопрос длительности существования ГКС-индуцированного ожирения у детей. По данным разных авторов, перенесенный в детстве СЧНС приводил к развитию избытка массы тела и ожи-рения у 8-23% взрослых [8,16]. J.…”

Section: обсуждение основного результата исследованияunclassified

Glucocorticosteroid Therapy and Physical Developmentof Children With Steroid-Sensitive Nephrotic Syndrome: A Retrospective Study

Zhdanova¹

2017

Vopr. sovr. pediatr.

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тела -1,85 ± 1,64 и -0,54 ± 1,14 соот-ветственно (р < 0,001). Избыток массы тела и ожирение имелись только у детей группы 1 (у 6 и 9 соответственно). Z-score длины тела пациентов групп 1 и 2 были сопоставимы и не отличались от нормальных величин (0,34 ± 1,08 и 0,52 ± 1,12 соответственно; р = 0,655). Отмечена корреляция значений Z-score длины тела и кумулятивных доз глюкокортикостероидов (r = -0,87; р < 0,001 (Group 2). The Z-score of body weight in children in these groups was 1.64 ± 1.54 and 0.05 ± 1.19 (p = 0.004), Z-score of body mass index was 1.85 ± 1.64 and -0.54 ± 1.14, respectively (p < 0.001). Excess body weight and obesity were only observed in children of Group 1 (in 6 and 9, respectively). The Z-score of the body length of patients in groups 1 and 2 were comparable and did not differ from normal values (0.34 ± 1.08 and 0.52 ± 1.12, respectively, p = 0.655

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“…In Kenntnis der Nebenwirkungen der Glukokortikoide und bei der Bewertung der Therapiealternativen sind folgende Fragestellungen relevant: 4 [14]. Die Vermeidung von Rezidiven ist primär ein Ansatz zur Reduktion der glukokortikoidassoziierten Nebenwirkungen.…”

Section: Steroidsensibles Nephrotisches Syndrom (Ssns)unclassified

Alternativen zur Steroidbehandlung des steroidsensiblen nephrotischen Syndroms im Kindesalter

et al. 2015

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Long-term outcomes in idiopathic nephrotic syndrome: from childhood to adulthood

Abstract: 1. High number of INS relapses in childhood is a risk factor for recurrences in adulthood. 2. INS relapses in childhood do not preclude active professional life in adulthood.

Cited by 54 publications

References 18 publications

Review on long‐term non‐renal complications of childhood nephrotic syndrome

Review on long‐term non‐renal complications of childhood nephrotic syndrome

Glucocorticosteroid Therapy and Physical Developmentof Children With Steroid-Sensitive Nephrotic Syndrome: A Retrospective Study

Alternativen zur Steroidbehandlung des steroidsensiblen nephrotischen Syndroms im Kindesalter

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