Long-term outcomes after native tissue vs. biological graft-augmented repair in the posterior compartment

Grimes, Cara L.; Tan-Kim, Jasmine; Whitcomb, Emily L.; Lukacz, Emily S.; Menefee, Shawn A.

doi:10.1007/s00192-011-1607-9

Cited by 18 publications

(4 citation statements)

References 33 publications

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“…In that study, the mesh was removed 30, 60, 90, 180, 360, 540, and 720 days after implantation and chronic inflammatory reactions around the mesh began to decrease 30 days after implantation, similar to what was observed in this study. Some studies have shown that while biological grafts are well tolerated and provide long-term success for pelvic floor reconstruction, this success rate is similar to that of traditional repair techniques that do not use graft materials [12,14,26] . However, this may be a result of material preparation.…”

Section: Discussionmentioning

confidence: 99%

Tissue Reactions to Heterogenic and Allogeneic Acellular Dermal Matrix Mesh Placed in the Vesicovaginal Space in a Rabbit Model

Yao

Zhang

Han

et al. 2016

Gynecol Obstet Invest

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Background and Aim: This study is aimed at investigating the tissue reactions of heterogenic and allogeneic acellular dermal matrix (ADM) mesh implanted in the vesicovaginal space in a rabbit model. Methods: Twenty eight rabbits were implanted with heterogenic or allogeneic mesh, respectively, in the vesicovaginal space, and 4 served as the no-implantation control group. Rabbits were sacrificed at 7, 30, and 90 days after implantation. Histopathological study and immunohistochemical examination for collagen were performed. Results: Heterogenic but not allogeneic mesh was identifiable at 90 days. In the allogeneic group, neovascularization was observed from day 7 after implantation. A chronic inflammatory reaction was noted in the heterogenic group at 30 days that decreased at 90 days. Inflammation was less in the allogeneic group, but giant cells and fibroblasts were present. With respect to collagen, the heterogenic mesh remained structurally unchanged at 90 days, while new collagen fibers were observed in the allogeneic group from day 7. Conclusion: The immunological outcomes of heterogenic and allogeneic ADM mesh are different. Heterogenic mesh induces a chronic inflammatory reaction at day 30 after implantation, and maintains its original form longer. Allogeneic mesh is associated with new collagen generation, but degrades earlier.

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Section: Discussionmentioning

confidence: 99%

Tissue Reactions to Heterogenic and Allogeneic Acellular Dermal Matrix Mesh Placed in the Vesicovaginal Space in a Rabbit Model

Yao

Zhang

Han

et al. 2016

Gynecol Obstet Invest

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show abstract

“…Only other prospective cohort study by Goldstein et al reported 88% success rate based on mean Ba and Bp points at one year follow up. This group of 43 demonstrated no erosions and significant improvement in PDFI-20(pelvic floor distress inventory score) [8,22]. Xenform Soft tissue repair matrix is derived from fetal dermal bovine tissues [7][8][9][10][11][12] that, per World Health Organisation and European designation, has no known detectable prion infectivity.…”

Section: Discussionmentioning

confidence: 99%

Results of Xenform® Matrix Repair in Treatment of Pelvic Organ Prolapse- A Four Year Study

Singla¹

2019

GJORM

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“…The key in management of genital prolapse is to correct weak native fascial support. 12 The aim in genital prolapse management is to correct anatomical defects, restore sexual function, maintain urinary bladder and intestinal functions, prevent recurrence, and improve quality of life. 13 Sacrospinous ligament is attached from ischial spine to the lateral part of the sacrum, and its fixation keeps the vaginal axis in the midline.…”

Section: Jsafomsmentioning

confidence: 99%

Sacrospinous Ligament Fixation in Patients having Second-degree Uterine Prolapse

Rady¹

2018

Journal of SAFOMS

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Introduction: Sacrospinous ligament fixation is a simple procedure we use to treat cases with uterine prolapse. Aim:The aim of this work is to test the effectiveness of this procedure in the treatment of second-degree uterine prolapse. Materials and methods:The study included 50 women having second-degree uterine prolapse. Twenty-five of them (group I) were treated with bilateral sacrospinous ligament fixation, while the others (group II) were treated with unilateral sacrospinous ligament fixation. Assessment of the efficacy, intraoperative, and postoperative complications was recorded (follow-up of patients occurred 3 and 6 months postoperatively). Results:The mean operative time in unilateral sacrospinous fixation is 52 ± 10.6 minutes, while in bilateral procedure, it is 73 ± 12.6 minutes, but postoperative pain is more in bilateral than unilateral procedure. Conclusion:Sacrospinous ligament fixation is an effective treatment for patients having second-degree uterine prolapse. Unilateral is better than bilateral sacrospinous operation regarding postoperative pain.

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Long-term outcomes after native tissue vs. biological graft-augmented repair in the posterior compartment

Abstract: Long-term success of posterior repair is high. Graft augmentation does not appear to improve anatomic or functional outcomes.

Cited by 18 publications

References 33 publications

Tissue Reactions to Heterogenic and Allogeneic Acellular Dermal Matrix Mesh Placed in the Vesicovaginal Space in a Rabbit Model

Tissue Reactions to Heterogenic and Allogeneic Acellular Dermal Matrix Mesh Placed in the Vesicovaginal Space in a Rabbit Model

Results of Xenform® Matrix Repair in Treatment of Pelvic Organ Prolapse- A Four Year Study

Sacrospinous Ligament Fixation in Patients having Second-degree Uterine Prolapse

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