Long-Term Outcome of Xenogenic Dermal Matrix Implantation in Immunocompetent Rats

DeSagun, Evangeline Z.; Botts, Jennifer L.; Srivastava, Taasin; Hanumadass, Marella; Walter, Robert

doi:10.1006/jsre.2000.6060

Cited by 33 publications

(15 citation statements)

References 41 publications

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“…39 Similarly, xenogenic (porcine) ADM used for fullthickness skin wounds in rats evokes a significant immune response, resulting in poor wound healing. 57,58 In contrast, the ADM used in this study is an allogenic material. Allogenic ADM has been used successfully as a substitute for dermis in animal models, 46,59 and in clinical trials for the management of burn wounds and leg ulcers 60 (Walter et al, unpublished data).…”

Section: Discussionmentioning

confidence: 90%

Closure of Abdominal Wall Defects Using Acellular Dermal Matrix

Walter

Nagy

2004

The Journal of Trauma: Injury, Infection, and Critical Care

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Section: Discussionmentioning

confidence: 90%

Closure of Abdominal Wall Defects Using Acellular Dermal Matrix

Walter

Nagy

2004

The Journal of Trauma: Injury, Infection, and Critical Care

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“…Mast cell infiltration is a feature of xenogenic implantation of acellular material in the immunocompetent recipient host. 17 Furthermore, mast cells appear to have a role in the recipient's response to vital xenografts and may have a role in tissue remodeling and angiogenesis. 12 Mast cell activation is known to be detrimental in graft-versus-host disease.…”

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confidence: 99%

Mast cell hyperplasia in chronic rejection after liver transplantation

O'Keeffe¹

2002

Liver Transplantation

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The pathogenesis of chronic hepatic allograft rejection is poorly understood. Recent studies suggested that hepatic mast cells may be involved in the pathogenesis of chronic cholestatic liver disease. Because chronic rejection after liver transplantation is predominantly a cholestatic process, the aim of this study is to determine whether hepatic mast cells are involved in its pathogenesis. Biopsy specimens from (1) normal livers (n ‫؍‬ 5), (2) transplanted livers with end-stage chronic rejection (n ‫؍‬ 8), and (3) transplanted livers with acute cellular rejection (mild, n ‫؍‬ 7; moderate, n ‫؍‬ 5; severe, n ‫؍‬ 7) were studied. Biopsy specimens were stained immunohistochemically for mast cells with human antitryptase antibody. Mast cell density was significantly increased in the chronic-rejection group (4.9 ؎ 0.6/mm 2 ) compared with controls (2.9 ؎ 0.5/ mm 2 ; P < .05). The percentage of portal tracts containing mast cells was significantly greater in chronic-rejection (89% ؎ 8%) than control biopsy specimens (69% ؎ 5%; P < .

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“…It is the main reason concerned by scholars, and has been confirmed by animal experiments 15) . (2) The biocompatibility of PADM is poor.…”

Section: Discussionmentioning

confidence: 78%

“…In addition, the dermal papillary layer is the area in which the heterogenous antigen is mostly easy to be remained. Desagun et al 15) have conducted an IHC experiment using anti-pig ADM antiserum and found that, there was no reaction of type I and III collagen in ADM with the most obvious reaction in basement layer area. So it is believed that, the type IV collagen in basement layer or laminin is the major source of porcine ADM antigen.…”

Section: Discussionmentioning

confidence: 99%

Vascularization of Novel Porcine Acellular Dermal Matrix

Bian

Chen

et al. 2014

J. Hard Tissue Biology.

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The aims of this study were to observe the growth of vascular endothelial cells (VECs) and the vascularization of novel porcine acellular dermal matrix (PADM), and to investigate the methods for modifying heterologous dermal substitutes in order to improve their compatibility. Twenty-four Wistar rats were divided into a PADM group and a HADM group, which were transplanted with PADM and HADM, respectively. At the 3rd day, and at the 1st, 2nd, and 4th week after the operation, the dermal substitute was removed, and HE staining and CD34 and factor VIII immunohistochemical staining were performed. The distribution and proliferation of VEC, the vascularization, and histological changes in the dermal substitute were observed. At the 3rd postoperative day, tiny capillaries sprouted in the dermal substitute and began to proliferate. At the 1st postoperative week, the new capillaries extended into the dermal substitute. At the 2nd postoperative week, the new capillaries had entered the dermal substitute and further increased in number, and were more mature than the capillaries in the 1 st postoperative week (P<0.05). At the 4th postoperative week, the capillaries were distributed everywhere in the dermal substitute, along with further matured VECs, but the capillary number was not significantly increased compared with the 2nd postoperative week (P> 0.05). There was a good VEC proliferation in implanted PADM, with immigrated fibroblasts and matured capillaries. The novel PADM showed good tissue compatibility.

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Long-Term Outcome of Xenogenic Dermal Matrix Implantation in Immunocompetent Rats

Cited by 33 publications

References 41 publications

Closure of Abdominal Wall Defects Using Acellular Dermal Matrix

Closure of Abdominal Wall Defects Using Acellular Dermal Matrix

Mast cell hyperplasia in chronic rejection after liver transplantation

Vascularization of Novel Porcine Acellular Dermal Matrix

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