Long-term outcome of vagus nerve stimulation therapy in patients with refractory epilepsy

Abubakr, Abuhuziefa; Wambacq, Ilse

doi:10.1016/j.jocn.2007.07.083

Cited by 36 publications

(31 citation statements)

References 13 publications

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“…However, none of the patients was free of seizures at their last follow-up visit in our study. This result was similar to other studies [38,39]. It indicated that VNS is not curative but essentially a palliative treatment.…”

Section: Discussionsupporting

confidence: 92%

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy

Wang

Chen

Lin

et al. 2009

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 92%

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy

Wang

Chen

Lin

et al. 2009

Journal of the Neurological Sciences

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“…Epileptic patients reported frequently changes in eating behavior with alteration in diet preferences (Abubakr and Wambacq, 2008). These reports generated further investigations, initially through pure serendipity, which subsequently used animal models to evaluate the effects of VNS on food intake and related weight control (for synthetic tables on VNS studies, please see Val-Laillet et al, 2010; McClelland et al, 2013a).…”

Section: Invasive Neuromodulation Strategies: Recent Developments Andmentioning

confidence: 99%

Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity

Val‐Laillet¹,

Aarts

Weber

et al. 2015

NeuroImage: Clinical

376

321

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Functional, molecular and genetic neuroimaging has highlighted the existence of brain anomalies and neural vulnerability factors related to obesity and eating disorders such as binge eating or anorexia nervosa. In particular, decreased basal metabolism in the prefrontal cortex and striatum as well as dopaminergic alterations have been described in obese subjects, in parallel with increased activation of reward brain areas in response to palatable food cues. Elevated reward region responsivity may trigger food craving and predict future weight gain. This opens the way to prevention studies using functional and molecular neuroimaging to perform early diagnostics and to phenotype subjects at risk by exploring different neurobehavioral dimensions of the food choices and motivation processes. In the first part of this review, advantages and limitations of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), pharmacogenetic fMRI and functional near-infrared spectroscopy (fNIRS) will be discussed in the context of recent work dealing with eating behavior, with a particular focus on obesity. In the second part of the review, non-invasive strategies to modulate food-related brain processes and functions will be presented. At the leading edge of non-invasive brain-based technologies is real-time fMRI (rtfMRI) neurofeedback, which is a powerful tool to better understand the complexity of human brain–behavior relationships. rtfMRI, alone or when combined with other techniques and tools such as EEG and cognitive therapy, could be used to alter neural plasticity and learned behavior to optimize and/or restore healthy cognition and eating behavior. Other promising non-invasive neuromodulation approaches being explored are repetitive transcranial magnetic stimulation (rTMS) and transcranial direct-current stimulation (tDCS). Converging evidence points at the value of these non-invasive neuromodulation strategies to study basic mechanisms underlying eating behavior and to treat its disorders. Both of these approaches will be compared in light of recent work in this field, while addressing technical and practical questions. The third part of this review will be dedicated to invasive neuromodulation strategies, such as vagus nerve stimulation (VNS) and deep brain stimulation (DBS). In combination with neuroimaging approaches, these techniques are promising experimental tools to unravel the intricate relationships between homeostatic and hedonic brain circuits. Their potential as additional therapeutic tools to combat pharmacorefractory morbid obesity or acute eating disorders will be discussed, in terms of technical challenges, applicability and ethics. In a general discussion, we will put the brain at the core of fundamental research, prevention and therapy in the context of obesity and eating disorders. First, we will discuss the possibility to identify new biological markers of brain functions. Second, we will highli...

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“…Electrical vagal nerve blockade has been employed in the treatment of refractory epilepsy. Accompanied weight reduction was reported[24,25], although not in all cases[26]. Vagal blocking therapy (VBLOC) was developed to induce intermittent intra-abdominal vagal blockade for the treatment of morbid obesity using high-frequency electrical currents.…”

Section: Discussionmentioning

confidence: 99%

Effects of sleeve gastrectomy plus trunk vagotomy compared with sleeve gastrectomy on glucose metabolism in diabetic rats

Zhong

Liu

et al. 2017

WJG

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AIMTo investigate the effects of sleeve gastrectomy plus trunk vagotomy (SGTV) compared with sleeve gastrectomy (SG) in a diabetic rat model.METHODSSGTV, SG, TV and Sham operations were performed on rats with diabetes induced by high-fat diet and streptozotocin. Body weight, food intake, oral glucose tolerance test, homeostasis model assessment of insulin resistance (HOMA-IR), hepatic insulin signaling (IR, IRS1, IRS2, PI3K and AKT), oral glucose stimulated insulin secretion, GLP-1 and ghrelin were compared at various postoperative times.RESULTSBoth SG and SGTV resulted in better glucose tolerance, lower HOMA-IR, up-regulated hepatic insulin signaling, higher levels of oral glucose-stimulated insulin secretion, higher postprandial GLP-1 and lower fasting ghrelin levels than the TV and Sham groups. No significant differences were observed between the SG and SGTV groups. In addition, no significant differences were found between the TV and Sham groups in terms of glucose tolerance, HOMA-IR, hepatic insulin signaling, oral glucose-stimulated insulin secretion, postprandial GLP-1 and fasting ghrelin levels. No differences in body weight and food intake were noted between the four groups.CONCLUSIONSGTV is feasible for diabetes control and is independent of weight loss. However, SGTV did not result in a better improvement in diabetes than SG alone.

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Long-term outcome of vagus nerve stimulation therapy in patients with refractory epilepsy

Cited by 36 publications

References 13 publications

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy

Long-term effect of vagus nerve stimulation on interictal epileptiform discharges in refractory epilepsy

Neuroimaging and neuromodulation approaches to study eating behavior and prevent and treat eating disorders and obesity

Effects of sleeve gastrectomy plus trunk vagotomy compared with sleeve gastrectomy on glucose metabolism in diabetic rats

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