Effects of sleeve gastrectomy plus trunk vagotomy compared with sleeve gastrectomy on glucose metabolism in diabetic rats

Abstract

AIMTo investigate the effects of sleeve gastrectomy plus trunk vagotomy (SGTV) compared with sleeve gastrectomy (SG) in a diabetic rat model.METHODSSGTV, SG, TV and Sham operations were performed on rats with diabetes induced by high-fat diet and streptozotocin. Body weight, food intake, oral glucose tolerance test, homeostasis model assessment of insulin resistance (HOMA-IR), hepatic insulin signaling (IR, IRS1, IRS2, PI3K and AKT), oral glucose stimulated insulin secretion, GLP-1 and ghrelin were compared at various postoperative times.RESULTSBoth SG and SGTV resulted in better glucose tolerance, lower HOMA-IR, up-regulated hepatic insulin signaling, higher levels of oral glucose-stimulated insulin secretion, higher postprandial GLP-1 and lower fasting ghrelin levels than the TV and Sham groups. No significant differences were observed between the SG and SGTV groups. In addition, no significant differences were found between the TV and Sham groups in terms of glucose tolerance, HOMA-IR, hepatic insulin signaling, oral glucose-stimulated insulin secretion, postprandial GLP-1 and fasting ghrelin levels. No differences in body weight and food intake were noted between the four groups.CONCLUSIONSGTV is feasible for diabetes control and is independent of weight loss. However, SGTV did not result in a better improvement in diabetes than SG alone.

Mechanisms of Weight Loss After Sleeve Gastrectomy and Adjustable Gastric Banding: Far More Than Just Restriction

“…Using a retrograde tracer, Ballsmider et al confirmed that SG induced the damage of the gastric vagal nerve and consequent compensation responses, which play a beneficial effect in weight control. A recent study in diabetic rats , however, showed that SG plus trunk vagotomy failed to change body weight, caloric intake, or glucose metabolism compared with SG alone. To explain the paradox, the authors speculated the formation of collateral innervations as well as the regulation of related neural pathways through the visceral nervous system.…”

The Genus Parabacteroides Is a Potential Contributor to the Beneficial Effects of Truncal Vagotomy–Related Bariatric Surgery

“…Actually, truncal vagotomy (TV) was promoted as a weight-loss procedure and resulted in good effects as early as 40 years ago [ 22 , 23 ], although lost focus with the development of SG and Roux-en-Y gastric bypass (RYGB) subsequently. In recent years, with increasing attention of vagus nerve on weight regulating, several studies have reported that TV or SG-TV resulted in drastic reductions of BW [ 24 , 25 ]. However, there is no study reported the effect of TV and TV-related BS on changing of gut microbiota.…”