“…Without PDA closure, 9 of 14 dogs survived <1 year after diagnosis 19. General guidelines for follow‐up after PDA closure in humans include re‐evaluation within 6 months often with no further evaluation required after 12 months if the ductus arteriosus is completely closed 26, 27. More specific long‐term re‐evaluation schedules are recommended for adults with PDA, those patients with concurrent congenital or acquired HD or residual ductal flow, and to monitor patients with devices, which have limited long‐term outcome information 27…”
BackgroundPublished information regarding survival and long‐term cardiac remodeling after patent ductus arteriosus (PDA) closure in dogs is limited.ObjectivesTo report outcome and identify prognostic variables in dogs with PDA, and to identify risk factors for persistent remodeling in dogs with a minimum of 12 months of follow‐up after closure.AnimalsFive hundred and twenty client‐owned dogs.MethodsRetrospective review of medical records of 520 dogs with PDA. Outcome was determined by contacting owners and veterinarians. Dogs with PDA closure and ≥ 12 months of follow‐up were asked to return for a re‐evaluation.ResultsIn multivariable analysis of 506 dogs not euthanized at the time of diagnosis, not having a PDA closure procedure negatively affected survival (HzR = 16.9, P < .001). In 444 dogs undergoing successful PDA closure, clinical signs at presentation (HzR = 17, P = .02), concurrent congenital heart disease (HD) (HzR = 4.8, P = .038), and severe mitral regurgitation (MR) documented within 24 hours of closure (HzR = 4.5, P = .028) negatively affected survival. Seventy‐one dogs with ≥ 12 months follow‐up demonstrated a significant reduction in radiographic and echocardiographic measures of heart size (P = 0) and increased incidence of acquired HD (P = .001) at re‐evaluation. Dogs with increased left ventricular size and low fractional shortening at baseline were more likely to have persistent remodeling at re‐evaluation.Conclusions and Clinical ImportancePatent ductus arteriosus closure confers important survival benefits and results in long‐term reverse remodeling in most dogs. Clinical signs at presentation, concurrent congenital HD, and severe MR negatively affect survival. Increased left ventricular systolic dimensions and systolic dysfunction at baseline correlated significantly with persistent remodeling.
“…Without PDA closure, 9 of 14 dogs survived <1 year after diagnosis 19. General guidelines for follow‐up after PDA closure in humans include re‐evaluation within 6 months often with no further evaluation required after 12 months if the ductus arteriosus is completely closed 26, 27. More specific long‐term re‐evaluation schedules are recommended for adults with PDA, those patients with concurrent congenital or acquired HD or residual ductal flow, and to monitor patients with devices, which have limited long‐term outcome information 27…”
BackgroundPublished information regarding survival and long‐term cardiac remodeling after patent ductus arteriosus (PDA) closure in dogs is limited.ObjectivesTo report outcome and identify prognostic variables in dogs with PDA, and to identify risk factors for persistent remodeling in dogs with a minimum of 12 months of follow‐up after closure.AnimalsFive hundred and twenty client‐owned dogs.MethodsRetrospective review of medical records of 520 dogs with PDA. Outcome was determined by contacting owners and veterinarians. Dogs with PDA closure and ≥ 12 months of follow‐up were asked to return for a re‐evaluation.ResultsIn multivariable analysis of 506 dogs not euthanized at the time of diagnosis, not having a PDA closure procedure negatively affected survival (HzR = 16.9, P < .001). In 444 dogs undergoing successful PDA closure, clinical signs at presentation (HzR = 17, P = .02), concurrent congenital heart disease (HD) (HzR = 4.8, P = .038), and severe mitral regurgitation (MR) documented within 24 hours of closure (HzR = 4.5, P = .028) negatively affected survival. Seventy‐one dogs with ≥ 12 months follow‐up demonstrated a significant reduction in radiographic and echocardiographic measures of heart size (P = 0) and increased incidence of acquired HD (P = .001) at re‐evaluation. Dogs with increased left ventricular size and low fractional shortening at baseline were more likely to have persistent remodeling at re‐evaluation.Conclusions and Clinical ImportancePatent ductus arteriosus closure confers important survival benefits and results in long‐term reverse remodeling in most dogs. Clinical signs at presentation, concurrent congenital HD, and severe MR negatively affect survival. Increased left ventricular systolic dimensions and systolic dysfunction at baseline correlated significantly with persistent remodeling.
“…[7][8][9] Estes podem ser utilizados, inclusive, nas variantes anatômicas mais incomuns. 10 Sem dúvida, a morfologia em janela continua apresentando limitações para sua oclusão, basicamente quando o diâmetro menor do canal supera os 3 mm.…”
“…The ADO is a device that has shown in many publications encouraging results and safety in PDA transcatheter closure [2,12,13]. Several investigations have shown the capability of this device to close the most frequent form of PDA -the conical one.…”
Section: Discussionmentioning
confidence: 99%
“…When the diameter of the PDA is larger, with typical conical aortic ampulla, closure with the Amplatzer Duct Occluder (ADO) [2] or the very similar but cheaper Cardio-O-Fix Occluder [3] has proved to be a safe and feasible method with excellent results in short and long term follow-up.…”
A b s t r a c tPatent ductus arteriosus (PDA) is one of the most prevalent congenital heart diseases. Transcatheter closure of PDA is the treatment method of choice. In spite of recent advances in transcatheter management, the occlusion of certain anatomical types of PDA remains a challenge. The aim of the study was to report novel use of the Amplatzer Vascular Plug type II (AVPII) for closure of large elongated type of PDA (type E according to Krichenko classification) in a 19-year-old man. In clinical examination a soft continuous murmur was heard in the 2-3 left intercostal space. Echocardiography confirmed left to right shunt through the PDA. Left ventricle and left atrium were at the upper limit for body weight. In angiography the duct was 20 mm long, 7 mm wide with 3 mm narrowing at the pulmonary end. For the procedure we applied a 12 mm AVPII. The AVPII is a self-expanding, nitinol wire mesh occluder dedicated for arterial and venous occlusion in the peripheral circulation. It was delivered through a 6 F catheter retrogradely. The distal disc and medial part of the AVPII were opened inside the duct, and the proximal disc in the pulmonary artery. Complete closure of the PDA was confirmed in angiography. No complications during the procedure or 3-month follow-up were observed. Application of the AVPII is a safe and effective method of treatment for adult patients with elongated type of PDA.Key words: device closure, patent ductus arteriosus S t r e s z c z e n i e Przetrwały przewód tętniczy (patent ductus arteriosus -PDA) jest częstą wrodzoną wadą serca, a przezcewnikowe zamykanie tej struktury -leczniczym postępowaniem z wyboru. Pomimo niewątpliwego postępu obserwowanego w kardiologii interwencyjnej, zamykanie niektórych anatomicznych postaci PDA pozostaje wyzwaniem. Celem pracy jest przedstawienie przypadku mężczyzny w wieku 19 lat, u którego PDA typu wydłużonego (według kwalifikacji Kirchenko -typ E) zamknięto przy zastosowaniu nowatorskiej metody, używając do tego celu Amplatzer Vascular Plug typ II (AVPII). W badaniu klinicznym stwierdzano u pacjenta ciągły szmer w 2-3 przestrzeni międzyżebrowej. Echokardiografia potwierdziła lewo-prawy przeciek na poziomie PDA. Wymiary lewej komory i lewego przedsionka były w górnych granicach normy dla masy ciała. W angiografii przewód tętniczy miał następujące wymiary: 20 mm długości, 7 mm średnicy i 3-milimetrowe zwężenie przy końcu płucnym. Do przezcewnikowego zamknięcia zastosowano AVPII 12 mm. AVPII jest samorozprężającym się implantem, wykonanym z siatki z nitynolowego drutu, stosowanym zwykle do zamykania nieprawidłowych połączeń w obwodowym układzie krążenia. Był on dostarczony odżylnie za pomocą cewnika 6 F. Dystalny dysk i środ-kową część AVPII otworzono w PDA, a proksymalny dysk w tętnicy płucnej. W kontrolnej angiografii stwierdzono całkowite zamknię-cie PDA. Nie obserwowano żadnych powikłań okołozabiegowych oraz w 3-miesięcznej obserwacji. Zastosowanie AVPII u dorosłego pacjenta z PDA typu wydłużonego jest bezpieczną i skuteczną metodą leczenia.Słowa kl...
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