2017
DOI: 10.1016/j.seizure.2016.09.002
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Long-term outcome of medically treated epilepsy

Abstract: While we still do not have a cure for epilepsy for all patients, relief of the medical and social consequences is available for many and hope is on the horizon for people with epilepsy.

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Cited by 43 publications
(43 citation statements)
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References 79 publications
(112 reference statements)
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“…This may be influenced by the long follow-up in this study, with the proportion seizure-free each year consistently greater than 80% after 6 years. This finding of higher proportions in terminal remission associated with longer follow-up was previously suggested in two smaller cohort studies 2 18. The high proportion with terminal remission seen in the NGPSE is not entirely explained by the inclusion of people with single seizures at presentation (table 3); 73% of those with more than one seizure at presentation were in terminal remission by the end of follow-up (80% in those with complete follow-up).…”
Section: Discussionsupporting
confidence: 73%
“…This may be influenced by the long follow-up in this study, with the proportion seizure-free each year consistently greater than 80% after 6 years. This finding of higher proportions in terminal remission associated with longer follow-up was previously suggested in two smaller cohort studies 2 18. The high proportion with terminal remission seen in the NGPSE is not entirely explained by the inclusion of people with single seizures at presentation (table 3); 73% of those with more than one seizure at presentation were in terminal remission by the end of follow-up (80% in those with complete follow-up).…”
Section: Discussionsupporting
confidence: 73%
“…In the literature, the definition and complex physiopathogenesis of DR, the latter resulting from the interaction of several factors, are widely discussed . According to Hauser, in theory all epilepsies should be considered as resistant to therapy because the action of AED is only palliative, and does not influence the causal pathobiology of the epilepsy .…”
Section: Discussionmentioning
confidence: 99%
“…In the literature, the definition and complex physiopathogenesis of DR, the latter resulting from the interaction of several factors, are widely discussed. [10][11][12][13][14][15][16][17][18][19][20][21] According to Hauser, in theory all epilepsies should be considered as resistant to therapy because the action of AED is only palliative, and does not influence the causal pathobiology of the epilepsy. 23 Cascino suggested a more operational definition at the clinical level by proposing as a DR marker the persistence of seizures over the years, even with appropriate mono/polytherapy and at the maximum tolerated doses.…”
Section: Discussionmentioning
confidence: 99%
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“…In patients with focal epilepsy that is refractory to antiepileptic drugs, epilepsy surgery can be a very efficient treatment. Therefore, the accurate location of the cortical areas to be removed by surgery (epileptogenic zone, EZ) is crucial.…”
Section: Introductionmentioning
confidence: 99%