Long-term outcome of infrainguinal bypass grafting in patients with serologically proven hypercoagulability

Curi, Michael A.; Skelly, Christopher L.; Baldwin, Zachary K.; Woo, David H.; Baron, Joseph M.; Desai, Tina R.; Katz, Daniel; McKinsey, James F.; Bassiouny, Hisham S.; Gewertz, Bruce L.; Schwartz, Lewis B.

doi:10.1067/mva.2003.114

Cited by 31 publications

(15 citation statements)

References 29 publications

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“…Four of these patients had a bypass failure, and all four had a known hypercoagulable disorder. Curi et al 25 have also suggested that the grafts of patients with a hypercoagulable state have inferior longterm patency; in their series, patients with hypercoagulability were also younger. Thus, younger patients presenting with lifestyle-limiting claudication or tissue loss should be evaluated for hypercoagulability before proceeding with revascularization.…”

Section: Discussionmentioning

confidence: 95%

Factors associated with early failure of infrainguinal lower extremity arterial bypass

Singh

Sidawy

DeZee

et al. 2008

Journal of Vascular Surgery

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Section: Discussionmentioning

confidence: 95%

Factors associated with early failure of infrainguinal lower extremity arterial bypass

Singh

Sidawy

DeZee

et al. 2008

Journal of Vascular Surgery

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“…17 The recent publication by Curi et al reports that patients with hypercoagulability were more likely to have undergone prior revascularisation than patients deemed 'normal'. 29 The limitation of this retrospective analysis is that only 18% of the group underwent formal thrombophilia screening and so the normal group might contain patients with a thrombophilia defect and there might be an underestimation of the prevalence of 13%. Despite this limitation the 5-year primary patency of infrainguinal reconstructions was poorer in those with defined hypercoagulability (28% vs. 35% p ¼ 0:004).…”

Section: Thrombophilia and Failure Of Interventionmentioning

confidence: 98%

Prevalence and Risk of Thrombophilia Defects in Vascular Patients

VIG¹,

CHITOLIE²,

SLEIGHT³

et al. 2004

European Journal of Vascular and Endovascular Surgery

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This paper reviews the available data on the prevalence of thrombophilia defects in patients with peripheral vascular disease (PVD) and attempts to delineate the risk of failure of vascular intervention in these patients. The prevalence of thrombophilia in stable claudicants is 25% and increases to 40% in those requiring revascularisation, compared to only 11% in the control group. The overall prevalence of thrombophilia defects in patients with premature atherosclerosis appears to be between 15 and 30%. The prevalence in the typical cohort of patients with PVD appears to be similar. All these studies have recruited patients with symptoms significant enough to warrant intervention. The overall prevalence of thrombophilia calculated from these trials, therefore, may not be truly indicative of the general vascular population who may not even present primary or secondary healthcare. The risk of thrombotic occlusion following arterial revascularisation in patients with an identified thrombophilia defect appears to be almost three times that of patients with no evidence of a thrombophilia defect. The best management of these patients has not been determined and needs to be evaluated by prospective randomized trials.

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“…Thrombophilia defects are associated with failed revascularization in patients with peripheral vascular disease; the data suggest that the failure rate may be over three times higher than in patients without such defects1–9. Studies also suggest that hyperhomocysteinaemia is associated with vein graft stenosis10–12.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of thrombophilia in patients with symptomatic peripheral vascular disease

Vig

Chitolie

Bevan

et al. 2006

British Journal of Surgery

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Long-term outcome of infrainguinal bypass grafting in patients with serologically proven hypercoagulability

Cited by 31 publications

References 29 publications

Factors associated with early failure of infrainguinal lower extremity arterial bypass

Factors associated with early failure of infrainguinal lower extremity arterial bypass

Prevalence and Risk of Thrombophilia Defects in Vascular Patients

The prevalence of thrombophilia in patients with symptomatic peripheral vascular disease

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