The prevalence of thrombophilia in patients with symptomatic peripheral vascular disease

Abstract

A quarter of patients with peripheral vascular disease had evidence of thrombophilia, and a third had hyperhomocysteinaemia.

Comparison between two functional assays to detect factor V Leiden

“…By using genetic tests as standard in the considered population, the overall prevalence of FVL carriers was 42.5%, the prevalence of homozygous patients was 4.5%. These results were higher than the prevalence reported in literature in patients with VTE (Vig et al, 2006).…”

“…Nevertheless the more usual diagnostic approach is the use of functional screening tests. Even in a selected series like the group of patients considered in this study, only a minority showed genetic defects (De Stefano et al, 2002;Vig et al, 2006). Genetic tests are much more expensive and labour intensive than any clot based screening assay (65 vs. 5 Euro/test) (Gessoni et al, 2007).…”

Reduced Protein C Activity Might be Associated With Progression of Peripheral Arterial Disease

“…There have been many reports showing the association between hypercoagulability and development or progress of atherosclerotic vascular disease. [6][7][8][9] Vig et al 10 reported that a quarter of patients with PAD had evidence of thrombophilia. In their other review article, 11 the risk of thrombotic occlusion following arterial revascularization in patients with an identified thrombophilia defect appeared to be almost 3 times that in patients without it.…”

Antiphospholipid Antibodies and Atherosclerosis: Insights from Systemic Lupus Erythematosus and Primary Antiphospholipid Syndrome

“…The platelet neutralization procedure in the DRVVT was found in 26 out of the 60 (43%) vascular patients compared with none of the 20 general surgical controls [30], though a later survey found a lower 4% prevalence of LA in 150 patients with peripheral vascular disease [31].…”