<i>Objective:</i> This study focuses on the relation between objective voice quality and the self-perception of a voice handicap. <i>Patients and Methods:</i> The study group consisted of 86 German-speaking patients (51 women, 35 men) suffering from benign dysphonia. The test persons completed the German version of the Voice-Related Quality of Life (V-RQOL) Questionnaire without prior information about their diagnosis and underwent voice analysis with the Dysphonia Severity Index (DSI) being the parameter of this study. <i>Results:</i> No correlation between V-RQOL and DSI could be found (p > 0.05). On the V-RQOL, women scored worse than men, but not at a significant level. Patients with dysphonia of organic origin scored significantly worse than patients with functional dysphonia (p = 0.026). On the DSI, men’s values were significantly lower than women’s (p = 0.001). Organic dysphonia caused significantly lower DSI values than functional dysphonia (p = 0.011). <i>Conclusion:</i> Objective voice quality and the individual perception of voice quality by the patient are independent parameters. Both need to be assessed in clinical practice.