Long-term outcome of hormonal status in Taiwanese children with Hashimoto’s thyroiditis

Wang, Shuo-Yu; Tung, Yung-Liang; Tsai, Wen–Yu; Lee, Jing-Sheng; Hsiao, Pei-Hung

doi:10.1007/s00431-006-0112-5

Cited by 23 publications

(19 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the children with mild TSH elevations (5-10 mU/l), the evidence of a benefit of L-T4 supplementation is even more limited and the only available study aiming to compare the effects of therapy versus no treatment seems to suggest that treatment is unable to modify post-therapy outcomes of hyperthyrotropinemia and to prevent the risk of a further TSH increase after therapy withdrawal (17). In that study, however, the study population included only children with idiopathic SH, whereas no literature data are available on the effects of L-T4 therapy versus no treatment in subjects with mild HTrelated SH (18)(19)(20).…”

Section: Discussionmentioning

confidence: 92%

Underlying Hashimoto's Thyroiditis Negatively Affects the Evolution of Subclinical Hypothyroidism in Children Irrespective of Other Concomitant Risk Factors

Aversa

Valenzise²,

Corrias³

et al. 2015

Thyroid

View full text Add to dashboard Cite

The association with HT exerts a negative influence on the evolution over time of mild SH, irrespective of other concomitant risk factors. In children with mild and HT-related SH, the risk of a deterioration in thyroid status over time is high (53.1%), while the probability of spontaneous TSH normalization is relatively low (21.9%). In contrast, in children with mild and idiopathic SH, the risk of a deterioration in thyroid status over time is very low (11.1%), whereas the probability of spontaneous TSH normalization is high (41.1%).

show abstract

Section: Discussionmentioning

confidence: 92%

Underlying Hashimoto's Thyroiditis Negatively Affects the Evolution of Subclinical Hypothyroidism in Children Irrespective of Other Concomitant Risk Factors

Aversa

Valenzise²,

Corrias³

et al. 2015

Thyroid

View full text Add to dashboard Cite

show abstract

“…The natural course of AT is highly variable among children and adolescents [7,9,18,19,20]. Mäenpää et al [18] in Finland followed up 46 children and adolescents with AT for 6.5 years and found a variable natural course with regard to thyroid size and hormone status.…”

Section: Discussionmentioning

confidence: 99%

“…Rallison et al [7], in a USA study, found that AT beginning in childhood resolved spontaneously in one third of the cases, progressed to hypothyroidism in another third and remained unchanged in the remaining one third. Wang et al [20] in China followed up 47 children and adolescents with AT for 6.4 ± 3.9 years and found that of the 22 patients with thyroid dysfunction, 11 became euthyroid during the follow-up period, suggesting a benign course of the disease. Among 160 Italian children with AT, 105 of which were euthyroid at baseline and 55 had subclinical hypothyroidism, more that 50% remained or became euthyroid after 5 years of follow-up [21].…”

Section: Discussionmentioning

confidence: 99%

Treatment with Thyroxine Reduces Thyroid Volume in Euthyroid Children and Adolescents with Chronic Autoimmune Thyroiditis

Scarpa

Kousta²,

Tertipi³

et al. 2010

Horm Res Paediatr

View full text Add to dashboard Cite

Background/Aims: Treatment with thyroxine in children with chronic autoimmune thyroiditis (AT) is controversial. The aim of this study is to investigate, by using thyroid ultrasonography, whether thyroxine influences thyroid volume in non-goitrous euthyroid children with AT. Methods: We studied 50 euthyroid non-goitrous children and adolescents with AT for 2 years by thyroid function tests and ultrasonography; 25 were randomized to receive thyroxine and 25 did not receive treatment. Median (IQR) age was 12.1 (11.1–13.2) years. Results: At baseline there was no difference in thyroid volume SDS between the two groups (treatment group 1.1 (0.7–1.5) and controls 0.9 (0.4–1.4), respectively). After 2 years the treatment group had lower thyroid volume SDS compared to the controls (0.6 (0.3–1.0) vs. 2.0 (1.1–2.3), p = 0.001). One child of the treatment group and 12 of the control group developed goiter. Two control children developed subclinical hypothyroidism. Within the treatment group, thyroid volume SDS was lower after 2 years of treatment (p = 0.002). Within the control group, thyroid volume SDS and TSH levels increased after 2 years of follow-up (p = 0.016, 1.9 (1.5–2.8) vs. 3.2 (2.4–4.4) mIU/ml, p = 0.006, respectively). Conclusions: Treatment with thyroxine reduces thyroid volume in non-goitrous euthyroid children with AT and may prevent goiter development.

show abstract

“…We evaluated the results of 7 observational studies in different ethnic populations in which the number of subjects was >10 and the follow-up was ≥2 years [134,135,136,137,138,139,140]. Overall, of 250 children evaluated for an average duration of 4.3 years, 33.9% became euthyroid; in 41.7% SCH persisted while in 24.4% of children the hypothyroidism worsened.…”

Section: Sch In Childhoodmentioning

confidence: 99%

2014 European Thyroid Association Guidelines for the Management of Subclinical Hypothyroidism in Pregnancy and in Children

Lazarus¹,

Brown²,

Daumerie³

et al. 2014

Eur Thyroid J

568

457

View full text Add to dashboard Cite

This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above the pregnancy-related reference range with a normal serum thyroxine concentration. Isolated hypothyroxinaemia (defined as a thyroxine level below the 2.5th centile of the pregnancy-related reference range with a normal TSH level) is also recognized in pregnancy. In the majority of SCH the cause is autoimmune thyroiditis but may also be due to iodine deficiency. The cause of isolated hypothyroxinaemia is usually not apparent, but iodine deficiency may be a factor. SCH and isolated hypothyroxinaemia are both associated with adverse obstetric outcomes. Levothyroxine therapy may ameliorate some of these with SCH but not in isolated hypothyroxinaemia. SCH and isolated hypothyroxinaemia are both associated with neuro-intellectual impairment of the child, but there is no evidence that maternal levothyroxine therapy improves this outcome. Targeted antenatal screening for thyroid function will miss a substantial percentage of women with thyroid dysfunction. In children SCH (serum TSH concentration >5.5-10 mU/l) normalizes in >70% and persists in the majority of the remaining patients over the subsequent 5 years, but rarely worsens. There is a lack of studies examining the impact of SCH on the neuropsychological development of children under the age of 3 years. In older children, the evidence for an association between SCH and impaired neuropsychological development is inconsistent. Good quality studies examining the effect of treatment of SCH in children are lacking.

show abstract

Long-term outcome of hormonal status in Taiwanese children with Hashimoto’s thyroiditis

Cited by 23 publications

References 16 publications

Underlying Hashimoto's Thyroiditis Negatively Affects the Evolution of Subclinical Hypothyroidism in Children Irrespective of Other Concomitant Risk Factors

Underlying Hashimoto's Thyroiditis Negatively Affects the Evolution of Subclinical Hypothyroidism in Children Irrespective of Other Concomitant Risk Factors

Treatment with Thyroxine Reduces Thyroid Volume in Euthyroid Children and Adolescents with Chronic Autoimmune Thyroiditis

2014 European Thyroid Association Guidelines for the Management of Subclinical Hypothyroidism in Pregnancy and in Children

Contact Info

Product

Resources

About