Long‐Term Outcome of Differentiated Thyroid Carcinoma: Experience in a Developing Country

Bhargav, Panchangam Ramakanth; Mishra, Anjali; Agarwal, Gaurav; Agarwal, Amit; Pradhan, Prasanta Kumar; Gambhir, Sanjay; Verma, Ashok Kumar; Mishra, Saroj Kanta

doi:10.1007/s00268-009-0293-y

Cited by 29 publications

(19 citation statements)

References 48 publications

(73 reference statements)

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“…Demographic features of 769 patients with Hashimoto's thyroiditis show a mean age of 41.76 ± 12.49 years, similar to the patients with C-FNAC [45]. In addition, in 302 patients with differentiated thyroid carcinoma (62% papillary thyroid carcinoma), Bhargav et al [46] found that the mean age of the patients was 42 ± 14 years. Younger age in our patients with C-FNAC compared to patients with A-FNAC, may be in relation to higher prevalence of lymphocytic thyroiditis and papillary carcinoma.…”

Section: Discussionmentioning

confidence: 69%

Complex thyroid nodules with nondiagnostic fine needle aspiration cytology: histopathologic outcomes and comparison of the cytologic variants (cystic vs. acellular)

García-Pascual

Barahona

Balsells

et al. 2010

Endocr

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Management of complex thyroid nodules (CTN) is a common dilemma due to their high prevalence and frequent nondiagnostic fine needle aspiration cytology (FNAC). In order to know the rate of malignancy, we reviewed our experience about histopathologic diagnosis of CTN with nondiagnostic FNAC, and we analyzed if cytological variants of nondiagnostic FNAC indicated different histopathologic outcomes. We conducted a review of 927 consecutive aspirations performed between 2003 and 2008. We selected patients without history of radiation, with echographic CTN, and nondiagnostic FNAC, who underwent surgery. We analyzed histopathologic results and compared patients with benign and malignant nodules, and searched for differences between patients with cystic changes in FNAC (C-FNAC), and patients with acellular or only bloody FNAC (A-FNAC). Thirty-six patients were included (mean age 45.7 ± 13 years; 30 females). Four patients had malignant nodules; all were papillary carcinomas. Patients with benign nodules had a similar profile to patients with malignant nodules. Patients with C-FNAC (n = 21) were younger (41.3 ± 12.6 vs. 51.8 ± 11.2 years; P < 0.02), had more lymphocytic thyroiditis (33.3 vs. 0%; P < 0.02), a slightly higher rate of carcinoma in the nodule (14.3 vs. 6.6%; P: ns), and also of papillary microcarcinoma outside the nodule (9.6 vs. 0%; P: ns) than patients with A-FNAC. In conclusion, we report an 11.1% malignancy rate in CTN with nondiagnostic FNAC. Nodules with C-FNAC variant had a slightly higher rate of malignancy than A-FNAC, which may be in relation with younger age and higher prevalence of lymphocytic thyroiditis in this group of patients.

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Section: Discussionmentioning

confidence: 69%

Complex thyroid nodules with nondiagnostic fine needle aspiration cytology: histopathologic outcomes and comparison of the cytologic variants (cystic vs. acellular)

García-Pascual

Barahona

Balsells

et al. 2010

Endocr

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“…It remains unclear whether this procedure confers an advantage on overall patient survival when associated with the risk of postoperative complications, such as hypoparathyroidism and recurrent laryngeal nerve injury [2, 3, 8–14]. Some authors claim that total thyroidectomy adds an unnecessary risk of complications in patients with MND and that postoperative use of thyroid hormone supplementation can be very effective in preventing the recurrence in most patients subjected to function-preserving thyroidectomies [2, 4].…”

Section: Discussionmentioning

confidence: 99%

Total thyroidectomy as the single surgical option for benign and malignant thyroid disease: a surgical challenge

Vassiliou

Tympa²,

Arkadopoulos³

et al. 2013

aoms

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IntroductionTotal thyroidectomy has been the treatment of choice for patients with malignant thyroid disease. However, the efficacy and safety of this procedure for patients with benign disease is still a matter of debate. The aim of this study is to show that total thyroidectomy can be safely performed for both malignant and benign disease.Material and methodsA retrospective study on 216 patients was conducted. Once an indication for surgery was established, our single surgical treatment was total thyroidectomy. Age, sex, nature of thyroid disease, final pathology and postoperative complications were recorded.ResultsFor both benign and malignant disease, total thyroidectomy resulted in no permanent laryngeal nerve injury and no permanent hypoparathyroidism. Temporary laryngeal nerve palsy occurred in 0.9% and 3% of patients with benign and malignant disease respectively (p = 0.245). Six percent of patients with benign and 10.0% of patients with malignant thyroid disease suffered temporary hypoparathyroidism (p = 0.280). Immediate reoperation for postoperative hemorrhage was performed in 1.7% of patients with benign disease and in 1.0% of patients with malignancy with an uneventful outcome (p = 0.650).ConclusionsWhen performed by surgeons experienced in endocrine surgery, total thyroidectomy may be considered as the treatment of choice for both malignant and benign thyroid disease requiring surgical treatment. Total thyroidectomy virtually eliminates the requirement of completion thyroidectomy for incidentally diagnosed thyroid carcinoma and significantly reduces the rate of reoperation for recurrent disease, as it provides an immediate and permanent cure for all benign thyroid diseases, with a low incidence of postoperative complications.

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“…Compared with papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) is more aggressive and harder to diagnose [4]. Although most FTCs can be cured with surgery, the overall 10-year survival rate of FTC is lower than that of PTC [5]. Therefore, understanding the molecular mechanisms of FTC tumours is important for developing better diagnostic strategies and improving the therapeutic outcome of FTC.…”

Section: Introductionmentioning

confidence: 99%

miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4

Zhao

Liang

et al. 2017

Oncotarget

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Follicular thyroid carcinoma (FTC) is a more aggressive form of thyroid cancer than the common papillary type. Alpha-2,8-sialyltransferase (ST8SIA) family members are expressed in various cancers and may be associated with FTC progression. In this study, we measured ST8SIA family expression in two FTC cell lines with different invasive potentials (FTC-133 and FTC-238) and Nthy-ori 3-1 cell lines, as well as FTC and normal thyroid tissues. ST8SIA4 was downregulated in the highly invasive FTC-238 cells and FTC tissues. Additionally, ST8SIA4 inhibited proliferation, migration and invasion of FTC both in vitro and in vivo. miR-146a and miR-146b were previously shown to be upregulated in thyroid carcinoma, and bioinformatics analyses indicated that miR-146a and miR-146b inhibit ST8SIA4. We found that miR-146a and miR-146b were significantly upregulated in FTC and promoted tumour progression. Furthermore, ST8SIA4 restoration decreased the invasiveness of miR-146a/b-overexpressing FTC-133 cells, and ST8SIA4 suppression reversed the effects of miR-146a/b inhibition in FTC-238 cells. We showed that miR-146a/b activated the PI3K-AKT-mTOR signalling pathway at least partially via suppression of ST8SIA4. Thus, our results demonstrate that miR-146a and miR-146b promote proliferation, migration and invasion of FTC via inhibition of ST8SIA4.

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Long‐Term Outcome of Differentiated Thyroid Carcinoma: Experience in a Developing Country

Abstract: Advance stage at presentation and proportionately high rates of FTC and PDTC contribute to poor outcome of DTC in developing countries. Despite dismal outcome, total thyroidectomy seems to prevent thyroid bed recurrence in surviving patients.

Cited by 29 publications

References 48 publications

Complex thyroid nodules with nondiagnostic fine needle aspiration cytology: histopathologic outcomes and comparison of the cytologic variants (cystic vs. acellular)

Complex thyroid nodules with nondiagnostic fine needle aspiration cytology: histopathologic outcomes and comparison of the cytologic variants (cystic vs. acellular)

Total thyroidectomy as the single surgical option for benign and malignant thyroid disease: a surgical challenge

miR-146a and miR-146b promote proliferation, migration and invasion of follicular thyroid carcinoma via inhibition of ST8SIA4

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