Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience

Jukić, Tomislav; Blažeković, Ivan; Franceschi, Maja; Ovčariček, Petra Petranović; Butković, Marija Bosak; Dabelić, Nina; Granić, Roko; Punda, Marija; Sonicki, Zdenko; Vagić, Davor; Fröbe, Ana; Kusić, Zvonko

doi:10.3390/diagnostics12040866

Cited by 15 publications

(10 citation statements)

References 30 publications

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“…The incidence of differentiated thyroid cancers (DTC) continues to increase worldwide, almost entirely due to the increasing detection of papillary thyroid cancer (PTC) (Vaccarella et al 2016 ). Most PTC are well differentiated, have relatively sedentary clinical behavior, and have mean 10-year survival rates between 80 and 95% (Sherman 2003 ; Jukic et al 2022 ). Despite the long survival associated with PTC, approximately 20–30% of patients relapse over several decades, with two-thirds of these relapses occurring within the first decade after initial treatment (Brassard et al 2011 ).…”

Section: Introductionmentioning

confidence: 99%

The value of the first postoperative diagnostic I-131 scan in patients with papillary thyroid carcinoma

Ran,

Shang,

Chen

et al. 2024

J Cancer Res Clin Oncol

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Objective To explore the feasibility of the postoperative diagnostic 131I whole-body planar scans (Dx-WBS) in papillary thyroid cancer (PTC) patients, and to clarify its value for accurate staging, risk stratification, and postoperative radioactive iodine (RAI) treatment management. Design Retrospective study from 2015 to 2021. Setting A total of 1294 PTC patients in the tertiary referral hospital. Participants Patients with differentiated thyroid cancer who underwent total/subtotal thyroidectomy were included. Patients with non-PTC pathological type, non-first RAI treatment, and incomplete data such as Dx-WBS and postablation WBS (Rx-WBS) were excluded. Methods The diagnostic efficacy of Dx-WBS was calculated with Rx-WBS as the reference. All patients were initially staged by the 8th edition of TNM staging, and risk stratification was performed based on clinical and pathological information. After Dx-WBS, the risk stratification was re-evaluated, and management was reconfirmed. Results The detection rates of Dx-WBS for residual thyroid, cervical lymph nodes, upper mediastinal lymph nodes, lung, and bone distant metastasis were 97.6%, 78.3%, 82.1%, 66.7%, and 61.2%, respectively. The risk stratification of 113 patients (8.7%) changed after Dx-WBS, of which 107 patients changed from low to intermediate risk, 2 from low to high risk, and 4 from medium to high risk. A total of 241 patients (18.6%) adjusted the RAI regimen after Dx-WBS. Conclusion This study confirms the diagnostic efficacy of the postoperative Dx-WBS in PTC patients and the value of Dx-WBS in accurately assessing risk stratification, as well as assisting in determining RAI treatment.

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Section: Introductionmentioning

confidence: 99%

The value of the first postoperative diagnostic I-131 scan in patients with papillary thyroid carcinoma

Ran,

Shang,

Chen

et al. 2024

J Cancer Res Clin Oncol

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“…Significant improvements in the diagnosis and treatment of DTC have provided an excellent prognosis. In general, overall survival rates for TC are high, especially in patients with DTC, with 10-year survival rates ranging from 80 to 95 percent ( 5 , 6 ). However, some studies in recent years have found an increase in mortality among patients with advanced-stage PTC ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

Development and validation of nomograms for predicting survival in differentiated thyroid cancer patients with or without radioiodine therapy

et al. 2023

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ObjectiveThis study aimed to establish and validate the nomograms for predicting overall survival (OS) probabilities in differentiated thyroid cancer (DTC) patients who received and did not receive radioiodine therapy (RAI), respectively.MethodsIn this study, 11, 099 patients diagnosed with DTC in the Surveillance, Epidemiology, and End Results (SEER) database from 2004 to 2016 were selected. Whether they have RAI, they are divided into RAI (n=6427) and non-RAI (n=4672) groups. They were randomly assigned to either a training cohort (RAI: n=4498, non-RAI: n=3263) or a validation cohort (RAI: n=1929, non-RAI: n=1399) using R software to divide the patients in a 7-to-3 ratio randomly. Variables were selected using a backward stepwise method in a Cox regression model to determine the independent prognostic factors, which were then utilized to build two nomograms to predict the 5-, 8-, and 10-year OS probabilities in DTC patients with or without RAI. The concordance index (C‐index), the area under the time-dependent receiver operating characteristics curve (AUC), the net reclassification improvement (NRI), the integrated discrimination improvement (IDI), calibration plotting, and decision-curve analysis (DCA) were used to evaluate the performance of our models.ResultsThe multivariate analyses demonstrated that birth of the year, race, histological type, tumor size, grade, TNM stage, lymph node dissections, surgery, and chemotherapy were risk factors for OS. Compared to the AJCC stage, the C‐index (RAI: training group: 0.911 vs. 0.810, validation group: 0.873 vs. 0.761; non-RAI: training group: 0.903 vs. 0.846, validation group: 0.892 vs. 0.808). The AUC values for the training cohort (RAI: 0.940, 0.933, and 0.942; non-RAI: 0.891, 0.884, and 0.852 for the 5-, 8-, and 10-year OS, respectively) and validation cohort (RAI: 0.855, 0.825, and 0.900, non-RAI: 0.867, 0.896, and 0.899), and the calibration plots of both two models all exhibited better performance. Additionally, the NRI and IDI further showed that they exhibited good 5-, 8-, and 10-year net benefits.ConclusionWe have established the prediction models of DTC patients with or without RAI respectively through various variables. The nomogram may be more targeted to guide clinical decisions in the future.

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“…1 Early differentiated thyroid cancer is compatible with long survival, necessitating the need for a prompt diagnosis and proper management. 2 Thyroid nodules are a common entity. Examination of autopsy specimens of those without clinical thyroid disease showed thyroid nodules larger than 1-cm in 50%.…”

Section: Introductionmentioning

confidence: 99%

The sensitivity of TIRADS scoring on ultrasonography in the management of thyroid nodules

2023

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Objective: To determine the sensitivity of ACR-TIRADS scoring by comparing its results with those obtained on biopsy of respective specimens. Method: This prospective study including N=205 patients with thyroid nodules was conducted in ENT Department of MTI Hayatabad Medical complex, Peshawar during the period from May 1, 2019 to April 30, 2022. Preoperative ultrasonography with assigning of TIRADS scores was performed in all patients. Appropriate thyroidectomies were performed in these patients and specimen biopsied. Pre-op TIRADS scores were compared with biopsy results. To determine the sensitivity of TIRADS, TR1 and TR2 were considered ‘benign’ and TR3, TR4, TR5 were considered ’malignant’ for comparison with biopsy results. Results: The mean age of patients was 37.68 years with standard deviation of ±11.52. The M: F ratio was 1:3.5. Nineteen patients (9.27%) had solitary thyroid nodules & 186 (90.73%) had multinodular goiters. TIRADS scoring was benign for 171 (83.41%) and malignant for 34 (16.58%) nodules. The biopsy results revealed 180 (87.80%) nodules to benign and the rest as malignant. The sensitivity, specificity and diagnostic accuracy were calculated at 80%, 92.77% and 91.21% respectively. Chi square test and p-value determination showed that there was a strong positive concordance between TIRADS scores & biopsy results which is highly significant (p=.001). Conclusion: The Ultrasonographic ACR-TIRADS scoring and risk stratification system is highly sensitive for detecting malignancy in thyroid nodules. It is, therefore, a reliable technique in the initial assessment of thyroid nodules and decisions can safely be based on its results. In cases of doubt, clinical judgment should be exercised before making final decision. doi: https://doi.org/10.12669/pjms.39.3.7313 How to cite this: Anwar K, Mohammad AY, Khan S. The sensitivity of TIRADS scoring on ultrasonography in the management of thyroid nodules. Pak J Med Sci. 2023;39(3):870-874. doi: https://doi.org/10.12669/pjms.39.3.7313 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Long-Term Outcome of Differentiated Thyroid Cancer Patients—Fifty Years of Croatian Thyroid Disease Referral Centre Experience

Cited by 15 publications

References 30 publications

The value of the first postoperative diagnostic I-131 scan in patients with papillary thyroid carcinoma

The value of the first postoperative diagnostic I-131 scan in patients with papillary thyroid carcinoma

Development and validation of nomograms for predicting survival in differentiated thyroid cancer patients with or without radioiodine therapy

The sensitivity of TIRADS scoring on ultrasonography in the management of thyroid nodules

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