Long‐term outcome in Caucasian patients with chronic hepatitis B virus infection after <scp>HB</scp>sAg seroclearance

Lauret, Eugenia; González-Diéguez, M.L.; Rodríguez, Mercedes; González, Maraelys Morales; Melón, Santiago; Rodrigo, Luís; Rodrı́guez, Manuel

doi:10.1111/liv.12461

Cited by 32 publications

(36 citation statements)

References 27 publications

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“…On the basis of abstracts, 104 studies were excluded and 50 retained and read in full. After reading the full text, 47 studies could be included in the analysis . Three were excluded because they reported inadequate data for calculating our primary or secondary outcomes .…”

Section: Resultsmentioning

confidence: 99%

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Systematic review of risk factors of hepatocellular carcinoma after hepatitis B surface antigen seroclearance

Kuang

Jia

Huo

et al. 2018

Journal of Viral Hepatitis

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There is no consensus about factors that increase risk of hepatocellular carcinoma (HCC) among patients with chronic hepatitis B who have achieved seroclearance of hepatitis B surface antigen (HBsAg). To assess the available evidence about risk factors for HCC after HBsAg seroclearance, Scopus, EMBASE, PubMed and Cochrane Library databases were systematically searched for relevant studies published through 15 September 2017. A total of 28 studies involving more than 105 411 patients with chronic hepatitis B were included. HBsAg seroclearance occurred spontaneously in 7656, while it occurred after interferon or nucleos(t)ide analogue therapy in 1248. The rate of HBsAg seroclearance was 6.77%. Incidence of HCC was significantly lower among patients who experienced HBsAg seroclearance than among those who remained HBsAg-positive (1.86% vs 6.56%, P < .001). Risk factors of HCC occurrence included cirrhosis (incidence with vs without: 9.51% vs 1.66%), male gender (2.34% vs 0.64%) and age ≥ 50 year at HBsAg seroclearance (2.34% vs 0.63%) (all P < .001). The available evidence suggests that HCC can develop at a low rate after HBsAg seroclearance, so periodic surveillance is recommended, especially for male patients, patients with cirrhosis and patients who experience HBsAg seroclearance when at least 50 years old.

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Section: Resultsmentioning

confidence: 99%

“…Four case reports were also excluded . In the end, 28 studies were included in the systematic review (Table ) . In four studies, elder patients were defined as patients older than 45 years or as patients older than 40 years .…”

Section: Resultsmentioning

confidence: 99%

Systematic review of risk factors of hepatocellular carcinoma after hepatitis B surface antigen seroclearance

Kuang

Jia

Huo

et al. 2018

Journal of Viral Hepatitis

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“…In a European study of 612 patients with compensated liver disease followed prospectively for 15 yr, 75 cleared HBsAg. Among those that cleared HBsAg, the incidence of liver-related complication (cirrhosis, hepatic decompensation, and HCC) was 1.8% compared with 11.6% for those with persistent HBsAg (Lauret et al 2014). The benefit was greatest in patients with cirrho-www.perspectivesinmedicine.org sis.…”

Section: Hbsag Seroclearancementioning

confidence: 86%

Viral Hepatitis B: Clinical and Epidemiological Characteristics

Burns

Thompson

2014

Cold Spring Harbor Perspectives in Medicine

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“…Host immunity also plays a role in the progress and outcome of HBV infection [8, 9]. Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogen- and damage-associated molecular pattern molecules and thus activate the innate immune system.…”

Section: Introductionmentioning

confidence: 99%

Correlation between polymorphisms in toll-like receptor genes and the activity of hepatitis B virus among treatment-naïve patients: a case-control study in a Han Chinese population

et al. 2018

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BackgroundBecause of the high prevalence and absence of cure for infection, chronic hepatitis B virus (HBV) infection has been acknowledged as a pressing public health issue. Toll-like receptors (TLRs) activate the human innate immune system and the polymorphisms in TLRs may alter their function. The present study aimed to investigate the association between TLR polymorphisms and disease progression of chronic HBV infection.MethodsDuring the study period, 211 treatment-naïve patients with chronic HBV infection were recruited, and blood samples were collected from each individual. Matrix-assisted laser desorption/ionization time of flight mass spectrometry was employed to genotype the selected TLR polymorphisms after human genome extraction. In addition, HbsAg, TNF-α, and IL-6 levels were quantified using enzyme linked immunosorbent assay (ELISA). Statistical analyses were conducted to investigate the association between TLR polymorphisms and hepatitis activity, liver function parameters, HbsAg level, and cytokine level.ResultsWe did not observe any mutations in rs4986790, rs4986791, and rs5743708 among all study subjects. A logistic regression revealed that mutations in rs3804099 and rs4696480 were associated with milder hepatitis activity. Consistent with the logistic regression, improved liver function parameters and reduced level of both HbsAg and cytokines were also correlated with the mutant carriers of rs3804099 and rs4696480.ConclusionsTLR mutations were significantly associated with milder hepatitis activity among patients with chronic HBV infection. Therefore, we conclude that the activation of TLR pathways may further intensify the inflammation of hepatocytes, and leads to progression of disease.

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Long‐term outcome in Caucasian patients with chronic hepatitis B virus infection after HBsAg seroclearance

Abstract: Hepatitis B surface antigen loss confers a significant clinical benefit in Caucasian subjects with HBV-related cirrhosis and in those with chronic HBV infection who receive antiviral therapy. However, HBsAg reappearance can be observed in selected cases.

Cited by 32 publications

References 27 publications

Systematic review of risk factors of hepatocellular carcinoma after hepatitis B surface antigen seroclearance

Systematic review of risk factors of hepatocellular carcinoma after hepatitis B surface antigen seroclearance

Viral Hepatitis B: Clinical and Epidemiological Characteristics

Correlation between polymorphisms in toll-like receptor genes and the activity of hepatitis B virus among treatment-naïve patients: a case-control study in a Han Chinese population

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