Long-term Outcome for Obstructive Sleep Apnea Syndrome Patients

Mortality in severe sleep apnoea/hypopnoea syndrome patients: impact of treatment

“…Thus, the relative risk of mortality presented by patients with nontreated SAHS would be at least in the order of 2-3 times that of the general population. As in previous works, the excess of mortality detected was basically due to cardiovascular [13,14,22,23] and respiratory [22] causes, which have been related to SAHS. Conversely, when SAHS patients were treated by surgery, weight loss or nCPAP, mortality was similar to that of the general population.…”

“…In the long term, this could contribute to reducing mortality, which in fact occurred in this study, although the nCPAP users may not have been as adherent as their subjective reports indicated [26]. However, the lower mortality registered in the present study in SAHS patients treated with diet or surgery had not been found previously [12,13]. In the control PSG, performed in 84% of these patients, a significant reduction in sleep-disordered breathing and cure of SAHS was observed in 35%, which could have had a similar influence to that of treatment with nCPAP.…”

“…It has been postulated that the above-mentioned complications could account for the increased mortality observed in a reduced number of studies in clinical populations [12][13][14]. The availability of nasal continuous positive airway pressure (nCPAP) since the early 1980s [15], which is effective in improving symptoms and limiting apnoea/hypopnoea episodes [16], implies that it is not ethical to conduct long-term studies that involve random assignment of symptomatic patients to groups without treatment.…”

Sleep Apnea and Cardiovascular Disease

“…10,51,58 Before widespread use of continuous positive airway pressure (CPAP) as a standard of care, 59,60 patients with OSA treated conservatively had increased mortality compared with OSA patients who had undergone tracheostomy, even though the latter group had a higher BMI (34 versus 31 kg/m 2 ) and more severe OSA (AHI, 69 versus 43). 61 Most deaths were cardiovascular. Similarly, another study showed that mortality in OSA patients with an AHI Ͼ20 was 0% over 8 years in those treated with tracheostomy or nasal CPAP, significantly lower than those treated with uvulopalatopharyngoplasty or those left untreated.…”

Μελέτη Διαταραχών Της Αναπνοής Στον Ύπνο Και Διάφορες Οφθαλμολογικές Παθήσεις

“…Η μελέτη των He και συνεργατών, όμως έδειξε καθαρή διαφορά επιβίωσης μεταξύ ασθενών με ΑΗΙ<20 και ασθενών με ΑΗΙ >20 (υπολογιζόμενη πιθανότητα επιβίωσης 0,96 και 0,63 αντίστοιχα), κυρίως για άτομα μικρότερα των 50 ετών [214]. Η θνητότητα στο ΣΑΑΥ είναι κυρίως αγγειακής προέλευσης [215], [216]. Μεταξύ 460 νεκροψιών ανδρών που πέθαναν από αιφνίδιο θάνατο, οι θάνατοι καρδιαγγειακής προέλευσης ήταν τέσσερις φορές συχνότεροι μεταξύ των ατόμων με σύνηθες ροχαλητό [217].…”