Mortality in severe sleep apnoea/hypopnoea syndrome patients: impact of treatment

Martí, Sergi; Sampol, Gabriel; Muñoz, Xavier; Torres, Ferrán; Roca, A. Planas; Lloberes, Patrícia; Sagalés, Teresa; Quesada, Pedro; Morell, Ferrán

doi:10.1183/09031936.02.00306502

Cited by 219 publications

(144 citation statements)

References 27 publications

(39 reference statements)

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“…Thus, mortality hazard ratios associated with the RDI categories 11-30 that only bordered on statistical significance would possibly move toward 1.0 after adjustment for additional relevant risk factors. Previous sleep apnoea mortality studies in which adjustment to confounders, such as medical condition at diagnosis, was carried out did not find any association between mortality and the severity of the syndrome [15,16]. Since the current authors did not have reliable data on treatment outcomes, the influence of treatment on mortality was also not examined.…”

Section: Discussionmentioning

confidence: 99%

“…Although there have been reports of increased rates of mortality in sleep apnoea patients [14][15][16], these reports, based on small groups, did not examine the contributing role of obesity, nor the relationship with the severity of sleep apnoea syndrome. In this investigation, these questions were addressed by conducting a follow-up mortality study in a large cohort of males clinically evaluated by polysomnography because of suspected sleep apnoea syndrome.…”

mentioning

confidence: 99%

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All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age

Lavie¹

2005

European Respiratory Journal

281

134

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The objective of this study was to assess whether an increasing severity of sleep apnoea is associated with increased all-cause mortality hazards and to assess whether the syndrome is associated with excess mortality, in comparison with the general population.Participants included 14,589 adult males, aged 20-93 yrs, referred to the sleep clinics with suspected sleep apnoea or diagnosed with sleep apnoea.Altogether, 372 deaths were recorded after a median follow-up of 4.6 yrs. The crude all-cause mortality rate was 5.55/1,000 patient yrs, increasing with apnoea severity. Cox proportional analysis revealed that both respiratory disturbance index (RDI) and body mass index significantly influenced all-cause mortality hazard but there was no interaction between them. Males with respiratory disturbance index .30 had a significantly higher mortality hazard rate than the reference group of males with RDI f10. Comparing mortality rates of males with moderate/severe sleep apnoea to the general population revealed that only males aged ,50 yrs showed an excess mortality rate.The hazard of mortality in sleep apnoea increases with apnoea severity as indexed by respiratory disturbance index. Moderate and severe levels of sleep apnoea are moderately associated with an increased risk of all-cause mortality, in comparison with the general population, particularly in males aged ,50 yrs. The lack of information about possible confounders and treatment effects should be taken into consideration in the interpretation of these results.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age

Lavie¹

2005

European Respiratory Journal

281

134

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“…Marti et al [67] followed a cohort of 444 patients, between the years 1982 and 1996. The cohort consisted of normals (no OSA) and those with OSA.…”

Section: Sleep Apnea Surgery In Childrenmentioning

confidence: 99%

Surgical Therapy of Obstructive Sleep Apnea: A Review

2012

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Obstructive sleep apnea (OSA) is a disease characterized by intermittent and repetitive narrowing of the airway during sleep. Surgical therapies for the treatment of OSA aim to improve airway patency by addressing selected site(s) of obstruction. Because several areas may each be responsible for the narrowing, different surgical modalities have also been developed. In this review, we give an overview of surgery for each of potential obstruction site(s). As a consequence of the multi-factorial and heterogeneous etiology of OSA, surgical therapies need to be selected and performed specifically for each patient, as there is no perfect surgery that will fit all patients. As with any other treatment modalities for OSA, surgical therapies have variable efficacy, but are a very important tool on OSA management in selected patients and have been shown effectiveness in decreasing the morbidity and mortality associated with the disease.

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“…Patienten mit schwerem OSAS haben jedoch durch die begleitenden Risikofaktoren ein deutlich gesteigertes Mortalitäts-risiko. Es konnte gezeigt werden, dass eine CPAP (continuous positive airway pressure)-Therapie dieses Risiko zu senken vermag (23).…”

Section: Gesteigertes Mortalitätsrisikounclassified

Obstructive sleep apnea syndrome - diagnostics

Hader

Sanner²,

Rasche³

2004

Dtsch med Wochenschr

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DefinitionUnter obstruktiver Schlafapnoe/-hypopnoe wird ein periodisches Sistieren (Apnoe) oder eine periodische Reduktion (Hypopnoe) der Atmung bedingt durch eine komplette oder inkomplette Okklusion der oberen Atemwege im Schlaf mit daraus resultierender Weckreaktion (Arousal) bei fortbestehender Aktivität der Atmungsmuskulatur verstanden (Abb.1). Ein obstruktives Schlafapnoe-Syndrom (OSAS) liegt dann vor, wenn aufgrund der schlafbezogenen Atmungsstörung Folgesymptome entstehen. Als Leitsymptome des OSAS finden sich exzessive Tagesschläfrigkeit, lautes und unregelmäßiges Schnarchen und Atemstillstände während des Schlafens (1, 12, 13). Klassifikation schlafbezogener Atmungsstörungen

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Mortality in severe sleep apnoea/hypopnoea syndrome patients: impact of treatment

Cited by 219 publications

References 27 publications

All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age

All-cause mortality in males with sleep apnoea syndrome: declining mortality rates with age

Surgical Therapy of Obstructive Sleep Apnea: A Review

Obstructive sleep apnea syndrome - diagnostics

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