Long-term oral complications of allogeneic haematopoietic SCT

Hull, Katrusha; Kerridge, Ian; Schifter, Mark

doi:10.1038/bmt.2011.63

Cited by 57 publications

(73 citation statements)

References 24 publications

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“…9 In most cases, stimulated saliva flow returned to normal levels within 2 years, but some patients suffered from persisting hyposalivation. Another recent study by Hull et al 10 reported comparable salivary gland hypofunction and xerostomia 6 to 24 months post-HSCT. Moreover, 21% of the subjects were affected by oral mucosal changes consistent with chronic GVHD (cGVHD) and coexisting with cutaneous, hepatic or ocular cGVHD.…”

Section: Introductionmentioning

confidence: 92%

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Daikeler

Mauramo

Rovó

et al. 2013

Bone Marrow Transplant

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The objective of this prospective cross-sectional case-control study was to examine the prevalence of dryness symptoms and its impact on quality of life (QoL) among very long-term survivors after hematopoietic SCT (HSCT) in comparison with their respective sibling donors. Forty-four allogeneic HSCT recipients with a long-term survival (median: 17.5; range: 11-26 years) were included. Their respective, HLA-identical sibling donors served as controls. Clinical examinations included saliva flow rates (SFR) and the Schirmer's test. The presence of sicca symptoms of mouth, eyes and skin were inquired. The social functioning (SF)-36 questionnaire was applied. Recipients had lower (Po0.01) unstimulated and stimulated mean SFR than donors. Schirmer's test results o5 mm was found in 45% of the recipients in comparison with 27% of the donors (P ¼ 0.07). Xerostomia (34 vs 4 subjects), xerophtalmia (23 vs 3) and dry skin (32 vs 12) were reported more often by the recipients than donors (Po0.001). Sicca symptoms and their objective findings correlated with QoL. The mean SF-36 scores of the donors were significantly higher than those of the recipients for physical component summary. In conclusion, sicca symptoms are common amongst long-term survivors of HSCT and affect remarkably the QoL.

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Section: Introductionmentioning

confidence: 92%

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Daikeler

Mauramo

Rovó

et al. 2013

Bone Marrow Transplant

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“…In fact, oral cGVHD often coexists with cutaneous, hepatic or ocular cGVHD. 25 According to Nakamura et al, 10 the histological alterations in MSG can reflect the cGVHD status. 10 Ductal dilation has been described as one of the histological findings for cGVHD diagnosis.…”

Section: Discussionmentioning

confidence: 99%

The impact of morphological and immunohistological changes in minor salivary glands on the health of the oral cavity in HSCT patients

Soares

Corrêa

Cintra

et al. 2013

Bone Marrow Transplant

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The objective of this study was to test the relationship between histological changes in minor salivary glands (MSG) and chronic GVHD (cGVHD) severity and OS of hematopoietic SCT (HSCT) patients, and to discriminate the participation of events preceding HSCT that damage MSG, from those linked to cGVHD. The MSG of 57 HSCT patients who were divided into two groups-oral cGVHD (36 cases) and non-cGVHD (21 cases)-were compared with the MSG of a control group of 19 non-HSCT individuals. cGVHD changes were assessed according to National Institutes of Health (NIH) consensus and the systems of Horn et al. Acinar areas and mononuclear cell subsets were set through morphometry. Horn's 'periductal lymphocytic infiltrate' correlated with an extensive form of cGVHD and NIH 'periductal lymphocytes with exocytosis into duct' correlated with global survival. Measurements of the acinar area differed between the three groups, being the lowest in cGVHD patients, but also reduced in non-cGVHD patients. Significant differences among CD45, CD45RO, CD4 and CD8 immunomarked cells/mm 2 were found by comparing the two groups of HSCT patients. In brief, periductal lymphocytic infiltrate and exocytosis implies inflammatory activity and, consequently, might reflect the cGVHD status and influence survival. Acini loss in non-cGVHD patients may be due to pre-transplant events, but massive lymphocyte infiltrate is part of the cGVHD process.

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“…The oral cavity is frequently involved, as the second most common site involved after skin due to HSCT, and oral manifestations occuring in 25 -90% of all cGVHD patients, often coexisting with cutaneous, hepatic or ocular cGVHD [2,7,9,[12][13][14][15][16]. It can be characterized as mucosal, salivary or sclerotic in nature, similary to several autoimmune conditions including Sjögren syndrome, oral lichen planus and scleroderma both clinical and histopathological presentation [12,13].…”

Section: Oral Gvhdmentioning

confidence: 99%

“…It can be characterized as mucosal, salivary or sclerotic in nature, similary to several autoimmune conditions including Sjögren syndrome, oral lichen planus and scleroderma both clinical and histopathological presentation [12,13].…”

Section: Oral Gvhdmentioning

confidence: 99%

See 1 more Smart Citation

Oral chronic graft-versus-host disease: A short review

Hsieh¹,

Souza²,

Paula³

et al. 2016

Trends in Transplant

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Allogeneic Hematopoietic Steam Cell Transplantation (allo-HSCT) treat a wide range of malignancies, including: neoplastic and non-neoplastic hematologic disease and immune deficiency states, and autoimmune disease. Chronic Graft-versus-host disease (cGVHD) is a major late complication of allo-HSCT, representing a clinical syndrome characterized by complex allogeneic and autoimmune dysregulation of the immune system, leading cause of non-relapse-related morbility and mortality among long-term transplant survivors. The oral cavity is frequently involved, as the second most common site involved after skin due to HSCT.The spectrum of clinical manifestation and histopathological characteristics of oral cGVHD are similar to several autoimmune conditions including Sjögren syndrome, oral lichen planus and scleroderma.Ancillary therapy is used for symptomatic oral mucosal or erythematous or ulcerative disease in GVHD treatment by using routine systemic drugs, several topical treatments as corticosteroids, non-corticosteroids, immunosuppressants, and phototherapy. For affected salivary glands, artificial saliva or saliva stimulators are commonly used to relief the xerostomia symptoms.

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Long-term oral complications of allogeneic haematopoietic SCT

Cited by 57 publications

References 24 publications

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT

The impact of morphological and immunohistological changes in minor salivary glands on the health of the oral cavity in HSCT patients

Oral chronic graft-versus-host disease: A short review

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